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Volumn 271, Issue 23, 1994, Pages 1876-1878

Sepsis Therapy Trials: Continued Disappointment or Reason for Hope?

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

EID: 0028305204     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1994.03510470080040     Document Type: Article
Times cited : (44)

References (11)
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    • Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition
    • Okusawa S, Gelfan JA, Ikejima T, et al. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest. 1988;81:1162-1172.
    • (1988) J Clin Invest , vol.81 , pp. 1162-1172
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  • 2
    • 0025266645 scopus 로고
    • Prognostic value of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γin the serum of patients with septic shock
    • Calandra T, Baumgartner J-D, Grau GE, et al. Prognostic value of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γin the serum of patients with septic shock. J Infect Dis. 1990;161:982-987.
    • (1990) J Infect Dis , vol.161 , pp. 982-987
    • Calandra, T.1    Baumgartner, J-D.2    Grau, G.E.3
  • 3
    • 0025225333 scopus 로고
    • An interleukin-1 receptor antagonist reduces mortality from endotoxin shock
    • Ohlsson K, Bjork P, Bergenfeldt M, et al. An interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature. 1990;348:550-552.
    • (1990) Nature , vol.348 , pp. 550-552
    • Ohlsson, K.1    Bjork, P.2    Bergenfeldt, M.3
  • 4
    • 0026772736 scopus 로고
    • Interleukin-1 receptor blockade improves survival and hemodynamic performance in E. coli septic shock, but fails to alter host responses to sublethal endotoxemia
    • Fischer E, Marano MA, VanZee KJ, et al. Interleukin-1 receptor blockade improves survival and hemodynamic performance in E. coli septic shock, but fails to alter host responses to sublethal endotoxemia. J Clin Invest. 1992;89:1551-1557.
    • (1992) J Clin Invest , vol.89 , pp. 1551-1557
    • Fischer, E.1    Marano, M.A.2    VanZee, K.J.3
  • 5
    • 0028018567 scopus 로고
    • Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled trial
    • Fisher CJ, Slotman GJ, Opal SM, et al. Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled trial. Crit Care Med. 1994;22:12-21.
    • (1994) Crit Care Med , vol.22 , pp. 12-21
    • Fisher, C.J.1    Slotman, G.J.2    Opal, S.M.3
  • 6
    • 0028239555 scopus 로고
    • Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled trial
    • Fisher CJ Jr, Dhainaut J-F A, Opal SM, et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled trial. JAMA. 1994;271:1836-1843.
    • (1994) JAMA , vol.271 , pp. 1836-1843
    • Fisher, C.J.1    Dhainaut, J.-F.A.2    Opal, S.M.3
  • 7
    • 0025917510 scopus 로고
    • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis
    • Greenman RL, Schein RM, Marin MA, et al. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. JAMA. 1991;266:1097-1102.
    • (1991) JAMA , vol.266 , pp. 1097-1102
    • Greenman, R.L.1    Schein, R.M.2    Marin, M.A.3
  • 8
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin
    • Zeigler EJ, Fisher CJ, Sprung CL, et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. N Engl J Med. 1991;324:429-436.
    • (1991) N Engl J Med , vol.324 , pp. 429-436
    • Zeigler, E.J.1    Fisher, C.J.2    Sprung, C.L.3
  • 9
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    • Efficacy of PAF antagonist (BN 52021) in reducing mortality of patients with severe gram-negative sepsis
    • Tenaillon A, Dhainaut JF, Letulzo Y, et al. Efficacy of PAF antagonist (BN 52021) in reducing mortality of patients with severe gram-negative sepsis. Am Rev Respir Dis. 1993;147:A97.
    • (1993) Am Rev Respir Dis , vol.147 , pp. A97
    • Tenaillon, A.1    Dhainaut, J.F.2    Letulzo, Y.3
  • 10
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    • The clinical evaluation of new drugs for sepsis: a prospective study design based on survival analysis
    • Knaus WA, Harrell FE, Fisher CJ Jr, et al. The clinical evaluation of new drugs for sepsis: a prospective study design based on survival analysis. JAMA. 1993;270: 1233-1241.
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    • Knaus, W.A.1    Harrell, F.E.2    Fisher, C.J.3
  • 11
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    • A controlled randomized double blind clinical trial of monoclonal antibody to human tumor necrosis factor (TNF MAb) in patients with sepsis syndrome
    • Wherry J, Wenzel R, Abraham E, et al. A controlled randomized double blind clinical trial of monoclonal antibody to human tumor necrosis factor (TNF MAb) in patients with sepsis syndrome. Chest. 1993;104:35.
    • (1993) Chest , vol.104 , pp. 35
    • Wherry, J.1    Wenzel, R.2    Abraham, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.