Mucoadhesive Ophthalmic Vehicles: Evaluation of Polymeric Low-Viscosity Formulations

Journal of Ocular Pharmacology

Volumn 10, Issue 1, 1994, Pages 83-92

  Saettone, M Fabrizio ^a   Monti, Daniela ^a   Torracca, Maria Tilde ^a   Chetoni, Patrizia ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CHONDROITIN SULFATE; CYCLOPENTOLATE; DRUG CARRIER; HEPARAN SULFATE; HYALURONIC ACID; MESOGLYCAN; MUCIN; PILOCARPINE; POLYGALACTURONIC ACID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; MALE; MIOSIS; MYDRIASIS; NONHUMAN; RABBIT; VISCOSITY;

ADHESIVENESS; ANIMAL; COMPARATIVE STUDY; CORNEA; CYCLOPENTOLATE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EVALUATION STUDIES; MALE; MUCINS; OPHTHALMIC SOLUTIONS; PILOCARPINE; POLYMERS; RABBITS; RANDOM ALLOCATION; RHEOLOGY; VEHICLES; VISCOSITY;

EID: 0028301814     PISSN: 87563320     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.1994.10.83     Document Type: Article

References (12)

1. Krishnamoorthy, R and Mitra, A.K. Mucoadhesive polymers in ocular drug delivery. In: Ophthalmic Drug Delivery Systems, Mitra A.K. ed. Marcel Dekker, Inc., New York, N.Y. 1993, pp. 199–221.
2. Slovin, E.M. and Robinson, J.R. Bioadhesives in Ocular Drug Delivery. In: Biopharmaceutics of Ocular Drug Delivery, Edman P., ed. CRC Press, Boca Raton, FLA, 1993, pp 145–157.
3. Duchêne D., Touchard, F. and Peppas, N.A., Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm., 14: 283-318,1988.
4. Saettone, M.F., Monti, D., Torracca, M.T., Chetoni, P., and Giannaccini, B., Muco-adhesive liquid ophthalmic vehicles Evaluation of macromolecular ionic complexes of pilocarpine. Drug Dev. Ind. Pharm. 15: 2475–2489, 1989.
5. Saettone, M.F., Chetoni, P., Torracca, M.T., Burgalassi, S., and Giannaccini, B. Evaluation of muco-adhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid. Int. J. Pharm., 51: 203–212, 1989.
6. Saettone, M.F., Giannaccini, B., Chetoni, P., Torracca, M.T., and Monti, D., Evaluation of high- and low-molecular weight fractions of sodium hyaluronate and an ionic complex as adjuvants for topical ophthalmic vehicles containing pilocarpine. Int. J. Pharm. 72: 131–139, 1991.
7. Saettone, M.F., Monti, D., Giannaccini, B., Salminen, L., and Huupponen, R. Macromolecular ionic complexes of cyclopentolate for topical ocular administration. Preparation and preliminary evaluation in albino rabbits. S.T.P. Pharma Sci. 2: 68–75, 1992.
8. Huupponen, R., Kaila, T., Saettone, M.F., Monti, D., Iisalo, E., Salminen, L., and Oksala, O. The effect of some macromolecular ionic complexes on the pharmacokinetics and -dynamics of ocular cyclopentolate in rabbits. J. Ocul. Pharmacol., 8: 59–67, 1992.
9. Hassan, E.E. and Gallo, J.M. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res., 7: 491–495, 1990.
10. Ram, A. High-shear viscometry. In: Rheology, theory and applications, Eirich, F.R., ed., Academic Press, New York, NY, 1967, pp. 251–263.
11. Caramella, C., Colombo, P., Conte, U. and La Manna A. Rheological analysis in the evaluation and prediction of the stability of suspensions. II Farmaco. Ed. Pr., 29: 318–332, 1974.
12. Thermes F., Molon-Nablot S. and Grove, J. Effects of acetylcysteine on rabbit conjunctival and corneal surfaces. Invest. Qphthalmol. Vis. Sci., 32: 2958–2963 (1991).