The nicotinic acetylcholine receptor: Structure and autoimmune pathology

Critical Reviews in Biochemistry and Molecular Biology

Volumn 29, Issue 2, 1994, Pages 69-123

  Conti Tronconi, Bianca M ^a,b   Mclane, Kathryn E ^a,c   Raftery, Michael A ^a,b   Grando, Sergei A ^b   Protti, Maria Pia ^d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Ionotropic neurotransmitter receptors; Ligand gated ion channels; Myasthenia gravis; Nicotinic receptor

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; AUTOANTIGEN; BUNGAROTOXIN; CATION CHANNEL; EPITOPE; FLAVITOXIN; HYBRID PROTEIN; MUSCLE PROTEIN; NEUROTOXIN; NEUROTRANSMITTER; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AUTOIMMUNITY; BINDING SITE; HISTORY OF MEDICINE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR RECOGNITION; MYASTHENIA GRAVIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; SENSORY NERVE CELL; SEQUENCE HOMOLOGY; SPECIES DIFFERENTIATION; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; HUMAN; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; MUSCLES; MYASTHENIA GRAVIS; RECEPTORS, NICOTINIC; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0028299642     PISSN: 10409238     EISSN: None     Source Type: Journal    
DOI: 10.3109/10409239409086798     Document Type: Article

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284. The role of the β4 subunit in determining the kinetic properties of neuronal nicotinic α3 receptors
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286. Location of ligand-binding sites on the nicotinic acetylcholine receptor α-subunit
287. δ-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor
288. Myasthenia gravis and related disorders
289. Myelin basic protein-specific T lymphocytes from MS patients and healthy individuals
290. Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor
291. Use of chemical modification and site-directed mutagenesis to probe the functional role of thiol groups on the gamma subunit of Torpedo californica acetylcholine receptor
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293. + cell lines from myasthenia gravis patients
294. Immunodominant regions for T helper sensitization on the human nicotinic receptor α subunit in myasthenia gravis
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297. + T epitopes on the embryonic γ subunit of human muscle acetylcholine receptor
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299. α-Toxin binding to acetylcholine receptor α1 79–191 peptides: intrinsic fluorescence studies
300. Acetylcholine receptor: complex of homologous subunits
301. Synthetic peptides used to locate the alpha-bungarotoxin binding site and immunogenic regions on alpha subunits of the nicotinic acetylcholine receptor
302. Structural features of the nicotinic acetylcholine receptor revealed by antibodies to synthetic peptides
303. Transmembrane topography of nicotinic acetylcholine receptor: immunochemical tests contradict theoretical predictions based on hydrophobicity profiles
304. Location of antigenic determinants on primary sequences of subunit of nicotinic acetylcholine receptors by peptide mapping
305. Inhibition of neuronal acetylcholine sensitivity by alpha-toxins from Bungarus multicinctus venom
306. 3H]chlorpromazine labels three amino acids of the acetylcholine receptor γ subunit: implications for the α-helical organization of regions of MII and for the structure of the ion channel
307. Mutations in the channel domain after desensitization of a neuronal nicotinic receptor
308. Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia
309. No direct correlation between serum antiacetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravis
310. A modified nicotinic acetylcholine receptor lacking the ion channel amphipathic helices
311. Neural modulation of immune function
312. Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis
313. Ultrastructural localization of the terminal and lytic ninth complement component (C9) at the motor endplate in myasthenia gravis
314. Involvement of distinct murine T cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein
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316. Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate
317. Elementary steps in synaptic transmission revealed by currents through single ion channels
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328. Thymektomic bei einem Fall von Morbus Basedowi mit Myasthenia
329. Primary structure of Torpedo acetylcholinesterase deduced from its cDNA sequence
330. Myasthenia gravis, a new hypothesis
331. γ and δ-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor
332. A structural model for the ligand-binding sites at the nicotinic acetylcholine receptor
333. Characterization of a component in chick ciliary ganglia that crossreacts with monoclonal antibodies to muscle and electric organ acetylcholine receptor
334. A glutamate receptor channel with high affinity for domoate and kainate
335. Acetylcholine receptor-reactive T lymphocytes from healthy subjects and myasthenia gravis patients
336. Demonstration of the transmembrane nature of the acetylcholine receptor by labeling with anti-receptor antibodies
337. Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels
338. Change in desensitization of cat muscle acetylcholine receptor caused by coexpression of Torpedo acetylcholine receptor sub-units in Xenopus oocytes
339. Assembly of mutant subunits of the nicotinic acetylcholine receptor lacking the conserved disulfide loop structure
340. T cell responses to human recombinant acetylcholine receptor α subunit in myasthenia gravis and controls
341. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
342. Primary structure of γ-subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence
343. Cloning, sequencing and expression of cDNA for a novel subunit of acetylcholine receptor from calf muscle
344. Primary structure of β subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence
345. Use of a cholinergic photoaffinity reagent to delineate multi-subunit involvement in binding sites of low and high affinity on Torpedo acetylcholine receptor
346. Site-directed mutagenesis of colicin E1 provides specific attachment sites for spin labels whose spectra are sensitive to local conformation
347. Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor
348. Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor
349. Myasmenia gravis: passive transfer from man to mouse
350. Curare can open and block ionic channels associated with cholinergic receptors
351. Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits
352. Mapping of surface structures of Electrophorus acetylcholine receptor using monoclonal antibodies
353. Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies
354. High affinity binding of alpha-bungarotoxin to the purified alpha-subunit and to its 27000-dalton proteolytic peptide from Torpedo marmorata acetylcholine receptor. Requirement for the sodium dodecyl
355. Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor
356. Role of the main immunogenic region of acetylcholine receptor in myasthenia gravis. An Fab monoclonal antibody protects against antigenic modulation by human sera
357. Decrease in acetylcholine receptor content of human myotube cultures mediated by monoclonal antibodies to α, β and γ subunits
358. Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor
359. The main immunogenic region of human muscle acetylcholine receptor is localized within residues 67–76 of the α subunit
360. Fine localization of the major α-bungarotoxin binding site to residues α189–195 of the Torpedo acetylcholine receptor: residues 189, 190, and 195 are indispensable for binding
361. Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: localization and microheterogeneity revealed by the use of synthetic peptides
362. Acetylcholine receptor in rabbit thymus: antigenic similarity between acetylcholine receptors of muscle and thymus
363. Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes
364. Two configurations of a channel forming membrane protein
365. The thymic “Myodzellen” and myasthenia gravis
366. Myasthenia gravis: immunological relationship between striated muscle and thymus
367. Antibody heterogeneity and specificity in myasthenia gravis
368. Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor
369. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat
370. Myasthenia gravis: effect of antibody binding of conservative substitutions of amino acid residues forming the main immunogenic region of the nicotinic acetylcholine receptor
371. Amino acid residues within the sequence region α55–74 of Torpedo nicotinic acetylcholine receptor interacting with antibodies to the main immunogenic region and with snake α-neurotoxins
372. In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor
373. Effects of thio-group modifications on the ion permeability control and ligand binding properties of Torpedo californica acetylcholine receptor
374. Treatment of myasthenia gravis with physostigmine
375. Organization of ligand binding sites at the acetylcholine receptor: a study with monoclonal antibodies
376. The thymus in myasthenia gravis
377. Antibody from patients with myasthenia gravis recognizes determinants unique to extrajunctional acetylcholine receptors
378. Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells
379. Molecular analysis of intrathymic nicotinic acetylcholine receptor
380. Purification and characterization of a nicotinic acetylcholine receptor from chick brain
381. Purification and characterization of a nicotinic acetylcholine receptor from rat brain
382. Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies
383. Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies
384. Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts
385. Approaches for studying the pathogenic T cells in autoimmune patients
386. Sympathetic innervation of murine thymus and spleen: a comparative histofluorescence study
387. Binding of alpha-bungarotoxin to proteolytic fragments of the alpha subunit of Torpedo acetylcholine receptor analyzed by protein transfer on positively charged membrane filters
388. Determination of the primary amino acid sequence specifying the alpha-bungarotoxin binding site on the alpha sub-unit of the acetylcholine receptor fro
389. Binding of alpha-bungarotoxin to synthetic peptides corresponding to residues 173–204 of the alpha subunit of Torpedo calf and human acetylcholine receptor and restoration of high-affinity binding by sodium dodecyl sulfate
390. Distribution of alpha-bungarotoxin binding sites over residues 173–204 of the alpha subunit of the acetylcholine receptor
391. Selective photoaffinity labeling of acetylcholine receptor using a cholinergic analogue
392. Affinity directed crosslinking of acetylcholine receptor in postsynaptic membranes
393. Affinity directed crosslinking of membrane-bound acetylcholine receptor polypeptides with photolabile 1972.-bungarotoxin derivatives
394. Quantitation of cation transport by reconstituted membrane vesicles containing purified acetylcholine receptor
395. Thiol-group modification of Torpedo californica acetylcholine receptor: subunit localization and effects on function
396. Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide
397. Immunological heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenic patients