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of special interest, A good review of major developments in this field, containing a detailed discussion of the different models put forward to explain the mechanisms of cytosolic oscillations.
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3Rs and RYRs in generating the complex spatiotemporal aspects of calcium waves and oscillations.
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2+ Oscillations at Fertilization of Mammalian Eggs
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Dev Biol
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of outstanding interest, Sympathetic neurons give repetitive calcium spikes when activated by caffeine and weak depolarization. Spiking depends upon the process of CICR from internal stores that are primed by calcium derived from the continuous influx of external calcium.
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Neuron
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Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
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of special interest, Confocal microscopy has revealed spontaneous localized bursts of calcium. Contour maps of these sparks reveal a diameter of about 1.5 μm, suggesting that they probably result from the opening of a single RYR.
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Science
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Redundant Mechanisms of Calcium-Induced Calcium Release Underlying Calcium Waves During Fertilization of Sea Urchin Eggs
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3 with heparin or the RYR with ruthenium red. Only when both receptors were blocked was wave generation reduced.
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of special interest, The first morphological description of an initiation site has come from studies on fertilization in ascidian eggs. Calcium waves initiate at the vegetal pole, which has a higher density of endoplasmic reticulum and calsequestrin.
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2+ Oscillations in Exocrine Cells Evoked by Agonists and Inositol Trisphosphate
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3R are located. The spiking in this apical zone can trigger a wave that spreads out towards the basal zone.
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Independent Modes of Propagation of Calcium Waves in Smooth Muscle Cells
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Increased Frequency of Calcium Waves in Xenopus laevis Oocytes that Express a Calcium-ATPase
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3 may allow it to exert more global effects including information transfer between cells.
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Acceleration of Intracellular Calcium Waves in Xenopuus Oocytes by Calcium Infux
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Synchronized Oscillations in Cytoplasmic Free Calciium Concentration in Confluent Bradykinin-Stimulated Bovine Pulmonary Artery Endothelial Cell Monolayers
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0027531791
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Gap Junctional Conductance Tunes Phase Difference of Cholecystokinin Evoked Calcium Oscillations in Pairs of Pancreatic Acinar Cells
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of special interest, Pairs of pancreatic cells oscillate in unison with each other but gradually drift apart as the gap junctions begin to uncouple. The two cells remained phase-locked when junctional communication was maintained by inhibiting PKC with polymyxin B.
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of special interest, Recent studies on calcium oscillations in glial cells is reviewed with special emphasis on the functional significance of neuronal-glial signalling.
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54
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Mechanisms and function of intercellular calcium signaling
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of special interest, A good summary of the different epithelia which display intercellular calciuim waves and their possible role in mucous clearance from the lung, wound repair, neuronal-glial interactions, bioluminescence and carcinogenesis.
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Calcium Waves in Astrocytes - Filling in the Gaps
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56
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Calcium Signalling of Glial Cells Along Mammalian Axons
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of outstanding interest, Glial cells lying alongside axons began to generate calcium oscillations in response to axonal electrical activity. Such neuronal-glial interactions may contribute to metabolic coupling and also to the growth and development of the glial system.
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(1993)
J Neurosci
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Neuronal Activity Triggers Calcium Waves in Hippocampal Astrocyte Networks
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Neuron
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0026701518
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Cell-to-Cell Spread of Calcium Signals Mediated by ATP Receptors in Mast Cells
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of special interest, Rat basophilic leukemia cells and mast cells respond to stimulation by releasing ATP which then diffuses away to induce calcium signals in neighbouring cells. This community effect mediated by a local hormone may contribute to inflammatory responses.
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(1992)
Nature
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Rhythmic Exocytosis Stimulated by GnRH-Inducd Calcium Oscillations in Rat Gonadotropes
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Tse1
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0027447128
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Confocal Microscopy Reveals Coordinated Calcium Fluctuations and Oscillations in Synaptic Boutons
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of special interest, Single synaptic boutons of the lizard neuromuscular junction display regular oscillations in the resting level of calcium. Such oscillaions may play some role in modulating transmitter release.
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2+ Oscillations and Rhythmic Hyperpolarizations of Pituitary Gonadotropes
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of special interest, At normal resting potentials, the voltage-operated calcium channels are inactive, but can be transiently activated to give a burst of action potentials when the cytosolic oscillator induces periodic membrane hyperpolarizations.
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Science
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Regulation of Neutrophil Motility and Adhesion by Intracellular Calcium Transients
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of special interest, Neutrophils respond to chemoattractants with repetitive calciium spiking that may contribute to motility by inducing a sequence of attachment-detachment events.
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Calcium Oscillations in Human T and Natural Killer Cells Depend Upon Membrane Potential and Calcium Influx
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