Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 2. Asymmetric synthesis of (1R,2S)-2-fluorocyclopropylamine

Tetrahedron

Volumn 50, Issue 13, 1994, Pages 3905-3914

  Akiba, Toshifumi ^a   Tamura, Osamu ^b   Hashimoto, Masaru ^b   Kobayashi, Yuko ^b   Katoh, Tadashi ^b   Nakatani, Kazuhiko ^b   Kamada, Masahiro ^a   Hayakawa, Isao ^a   Terashima, Shiro ^b  

^a DAIICHI SANKYO CO   (Japan)

^b SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

Author keywords

(1R,2S) 2 fluorocyclopropylamine; (4R,5S) 2 diphenyl 3 vinyl 2 oxazolidinone; asymmetric synthesis; diastereoface selective, cyclopropanation; quinolonecarboxylic acid

Indexed keywords

2 FLUOROCYCLOPROPYLAMINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SITAFLOXACIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0028297594     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)89666-6     Document Type: Article

References (16)

1. The formation of a halogenocarbenoid of zinc. A novel synthetic route to halogenocyclopropane derivatives
2. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
3. Darstellung von 1-fluor-1-jod-cyclopropanen