Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40

Journal of Immunology

Volumn 152, Issue 6, 1994, Pages 2821-2829

  Parry, Sarah L ^a,b   Hasbold, Jhagvaral ^a   Holman, Mary ^a   Klaus, Gerry G B ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b Sunley Research Centre ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AVIDIN; CD45 ANTIGEN; DNA; HYBRID PROTEIN; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 4; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; LYMPHOCYTE MEMBRANE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CROSS LINKING; DNA SYNTHESIS; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; APOPTOSIS; B-LYMPHOCYTES; CELLS, CULTURED; DNA; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MODELS, BIOLOGICAL; RECEPTORS, FC;

EID: 0028294575     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Nemazee, D. A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC Class I antibody genes. Nature 337:562.
2. Okamoto, M., M. Murakami, A. Shimizu, S. Ozaki, T. Tsubata, S. Kumagai, and T. Honjo. 1992. A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175:71.
3. Brombacher, F., G. Kohler, and H. Eibel. 1991. B cell tolerance in mice transgenic for anti-Cd8 immunoglobulin mu chain. J. Exp. Med. 174:1335.
4. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353:765.
5. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, R. J. Trent, and A. Basten. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
6. Berek, C., and C. Milstein. 1988. The dynamic nature of the antibody repertoire. Immunol. Rev. 105:5.
7. Rajewsky, K., I. Forster, and A. Cumano. 1987. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238:1088.
8. Maclennan, I. C. M., Y. J. Liu, and G. D. Johnson. 1992. Maturation and dispersal of B cell clones during T cell-dependent antibody responses, Immunol. Rev. 126:143.
9. Goodnow, C. C., J. Crosbie, H. Jorgensen, R. A. Brink, and A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342:385.
10. Russell, D. M., Z. Dembic, G. Morahan, J. F. Miller, K. Burki, and D. Nemazee. 1991. Peripheral deletion of self-reactive B cells. Nature 354:308.
11. Murakami, M., T. Tsubata, M. Okamoto, A. Shimizu, S. Kumagai, H. Imura, and T. Honjo. 1992. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357:77.
12. Brown, D. M., G. L. Warner, J. E. Ales-Martinez, D. W. Scott, and R. P. Phipps. 1992. Prostaglandin E2 induces apoptosis in immature normal and malignant B lymphocytes. Clin. Immunol. Immunopathol. 63:221.
13. Hartley, S. B., M. P. Cooke, D. A. Fulcher, A. W. Harris, S. Cory, A. Basten, and C. C. Goodnow. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72:325.
14. Metcalf, E. S., and N. R. Klinman. 1976. In vitro tolerance induction of neonatal murine B cells. J. Exp. Med. 143:1327.
15. Chang, T. L., G, Capraro, R. E. Kleinman, and A. K. Abbas. 1991. Anergy in immature B lymphocytes: differential responses to receptor-mediated stimulation and T helper cells. J. Immunol. 147:750.
16. Brines, R. D., and G. G. B. Klaus. 1991. Effects of anti-Ig antibodies, IL-4 and second messenger agonists on B cells from neonatal mice. Int. Immunol. 3:461.
17. Brines, R. D., and G. G. B. Klaus. 1992. Inhibition of lipopolysaccharide-induced activation of immature B cells by anti-mu and anti-delta antibodies and its modulation by IL-4. Int. Immunol. 4:765.
18. Klaus, G. G. B., J. G. Howard, and M. Feldmann. 1976. Mechanisms of B-cell tolerance. Br. Med. Bull. 32:141.
19. Julius, M. H., C. H. Heusser, and K. Hartmann. 1984. Induction of resting B cells to DNA synthesis by soluble monoclonal anti-immunoglobulin. Eur. J. Immunol. 14:753.
20. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of IL-2, 3 or 4 using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
21. Lane, P. J. L., T. Brocker, S. Hubele, E. Padovan, A. Lanzavecchia, and F. McConnell. 1993. Soluble CD40 ligand can replace the normal T cell-derived CD40 signal to B cells in T cell-dependent activation. J. Exp. Med. 177:1209.
22. Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
23. Hawrylowicz, C. M., K. D. Keeler, and G. G. B. Klaus. 1984. Activation and proliferation signals in mouse B cells. I. A comparison of the capacity of anti-Ig antibodies or phorbol myristic acetate to activate B cells from CBA/N or normal mice into G1. Eur. J. Immunol. 14:244.
24. Gambier, J. C., Z. Z. Chen, J. Pasternak, J. T. Ransom, V. Sandoval, and H. Pickles. 1988. Ligand-induced desensitization of B cell membrane immunoglobulin mediated calcium mobilization and protein kinase C translocation. Proc. Nat. Acad. Sci. USA 85:6493.
25. Harnett, M. M., M. Holman, and G. G. B. Klaus. 1989. Regulation of sIgM and IgD-mediated inositol phosphate formation and calcium mobilization in murine B lymphocytes. Eur. J. Immunol. 19:1933.
26. Illera, V. A., C. E. Perandones, L. L. Stunz, D. A. Mower, and R. F. Ashman. 1993. Apoptosis in splenic B lymphocytes: regulation by protein kinase C and IL-4. J. Immunol. 151:2965.
27. Mond, J. J., E. Segal, J. T. Kung, and F. D. Finkelman. 1981. Increased expression of I-region-associated antigen on B cells after crosslinking of surface Ig. J. Immunol. 127:881.
28. Brines, R. D., and G. G. B. Klaus. 1993. Polyclonal activation of immature B cells by preactivated T cells: the role of interleukin-4 and CD40-ligand. Int. Immunol. 5:1445.
29. Maliszewski, C. R., K. Grabstein, W. C. Fanslow, R. J. Armitage, M. K. Spriggs, and T. A. Sato. 1993. Recombinant CD40 ligand stimulation of B cell growth and differentiation: cooperative effects of cytokines. Eur. J. Immunol. 23:1044.
30. Brink, R., C. C. Goodnow, J. Crosbie, E. Adams, J. Eris, D. Y. Mason, S. B. Hartley, and A. Basten. 1992. Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen. J. Exp. Med. 176:991.
31. Dintzis, H. M., and R. Z. Dintzis. 1992. Profound suppression by antigen of persistent IgM, IgG and IgE antibody production. Proc. Nat. Acad. Sci. USA 89:1113.
32. Johnson, J. G., and R. Jemmerson. 1992. Tolerance induction in resting memory B cells specific for a protein antigen. J. Immunol. 148:2682.
33. Linton, P. J., A. Rudie, and N. R. Klinman. 1991. Tolerance susceptibility of newly generating memory B cells. J. Immunol. 146: 4099.
34. Liu, Y. J., D. E. Joshua, G. T. Williams, C. A. Smith, J. Gordon, and I. C. MacLennan. 1989. Mechanism of antigen-driven selection in germinal centres. Nature 342:929.
35. Cooper, M. D., J. F. Kearney, W. E. Gathings, and A. R. Lawton. 1980. Effects of anti-Ig antibodies on the development and differentiation of B cells. Immunol. Rev. 52:29.
36. Sidman, C. L., and E. R. Unanue. 1975. Receptor-mediated inactivation of early B lymphocytes. Nature 257:149.
37. Nossal, G. J. V. 1983. Cellular mechanisms of immunologic tolerance. Annu. Rev. Immunol. 1:33.
38. Bretscher, P. 1992. The two-signal model of lymphocyte activation twenty-one years later. Immunol. Today 13:74.
39. Noelle, R. J., J. A. Ledbetter, and A. Aruffo. 1992. CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation. Immunol. Today 13:431.
40. Banchereau, J., P. Depaoli, A. Valle, E. Garcia, and F. Rousset. 1991. Long-term human B-cell lines dependent on interleukin-4 and antibody to CD40. Science 251:70.
41. Go, N. F., B. E. Castle, R. Barrett, R. Kastelein, W. Dang, T. R. Mosmann, K. W. Moore, and M. Howard. 1990. Interleukin-10, a novel B cell stimulatory factor: unresponsiveness of X-chromosome linked immunodeficiency B cells. J. Exp. Med. 172:1625.
42. Tsubata, T., J. Wu, and T. Honjo. 1993. B cell apoptosis induced by antigen receptor crosslinking is blocked by a T cell signal through CD40. Nature 364:645.
43. Parker, D. C. 1975. Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin. Nature 258:361.
44. Pure, E., and E. S. Vitetta. 1980. Induction of murine B cell proliferation by insolubilized anti-immunoglobulins. J. Immunol. 125:1240.
45. Brunswick, M., F. D. Finkelman, P. F. Highet, J. K. Inman, and H. M. Dintzis. 1988. Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation. J. Immunol. 140:3364.
46. Pecanha, L. M. T., C. M. Snapper, F. D. Finkelman, and J. J. Mond. 1991. Dextran-conjugated anti-Ig antibodies as a model for TI-2 antigen-mediated stimulation of Ig secretion in vitro. I. Lymphokine dependence. J. Immunol. 146:833.
47. Ucker, D. S., J. D. Ashwell, and G. Nickas. 1989. Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation. J. Immunol. 143: 3461.