Comparison of the Effect of Calpain Inhibitors on Two Extralysosomal Proteinases: The Multicatalytic Proteinase Complex and m‐Calpain

Journal of Neurochemistry

Volumn 62, Issue 5, 1994, Pages 1989-1994

  Figueiredo‐Pereira, Maria E ^a   Banik, Naren ^b   Wilk, Sherwin ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Brain proteinases; Calpain; Calpain inhibitors; Multi catalytic proteinase; Proteolysis

Indexed keywords

AMINO ACID; BETA CASEIN; CALPAIN; CALPASTATIN; CALPEPTIN; PROTEASOME; PROTEIN; PROTEINASE;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CATTLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GEL FILTRATION CHROMATOGRAPHY; HYPOPHYSIS; ION EXCHANGE CHROMATOGRAPHY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CALPAIN; CATTLE; CYSTEINE ENDOPEPTIDASES; DIPEPTIDES; KINETICS; LEUPEPTINS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PITUITARY GLAND; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; SUBSTRATE SPECIFICITY;

ANIMALIA; BOS TAURUS;

EID: 0028293250     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1994.62051989.x     Document Type: Article

References (41)

1. A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices
2. The presence of ATP/ubiquitin‐dependent proteinase complex in bovine brain
3. Calcium‐activated neutral protease (calpain) system: structure, function and regulation
4. Cleavage of amyloid β peptide during constitutive processing of its precursor
5. ATP‐dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin
6. Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic β‐protein fragments
7. Proteinase yscE, the yeast proteasome/multicatalytic‐multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival
8. Ubiquitin/ATP‐dependent protease
9. Localization of calpain immunoreactivity in senile plaques and in neurons undergoing neurofibrillary degeneration in Alzheimer's disease
10. Significant amount of multicatalytic proteinase complex identified on membrane from human erythrocyte
11. Two‐way cleavage of β‐amyloid protein precursor by multicatalytic proteinase
12. Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains
13. Cleavage of structural proteins during the assembly of th'e head of bacteriophage T4
14. Inhibition of proteolysis protects hippocampal neurons from ischemia
15. Protein measurements with the Folin phenol reagent
16. 2 protein digestion by a brain endoproteinase complex
17. Brain spectrin, calpain and longterm changes in synaptic efficacy
18. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
19. The multicatalytic proteinase complex, a major extralysosomal proteolytic system
20. Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity
21. A multicatalytical protease complex from pituitary that forms enkephalin and enkephalin containing peptides
22. Generation of methionine and leucine enkephalin from precursor molecules by cation‐sensitive neutral endopeptidase of bovine pituitary
23. Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein
24. Calpain inhibitors significantly decrease the catalytic activities of a major extra‐lysosomal proteinase, the multicatalytic proteinase complex
25. 3,4‐Dichloroisocoumarin‐induced activation of the degradation of β‐casein by the bovine pituitary multicatalytic proteinase complex
26. Specificity of calcium‐activated neutral proteinase (CANP) inhibitors for human μCANP and mCANP
27. Widespread activation of calcium‐activated neutral proteinase (calpain) in the brain in Alzheimer's disease: a potential molecular basis for neuronal degeneration
28. Purification and characterization of multicatalytic proteinase from eggs of the ascidian Halocynthia roretzi
29. β‐Amyloid precursor protein of Alzheimer disease occurs as 110‐ to 135‐kilodalton membrane‐associated proteins in neural and nonneural tissues
30. Evidence that β‐amyloid protein in Alzheimer's disease is not derived by normal processing
31. A high molecular weight protease in the cytosol of rat liver. 1. Purification, enzymological properties and tissue distribution
32. Synthesis of a new cell penetrating calpain inhibitor (calpeptin)
33. Activities of proteinase inhibitors of microbial origin
34. Inhibition of the chymotrypsin‐like activity of the pituitary multicatalytic proteinase complex
35. Developing selective inhibitors of calpain
36. Cation‐sensitive neutral endopeptidase: isolation and specificity of the bovine pituitary enzyme
37. Evidence that pituitary cation‐sensitive neutral endopeptidase is a multicatalytic protease complex
38. Identification and partial purification of a cation‐sensitive neutral endopeptidase from bovine pituitaries
39. Chemical modification of the bovine pituitary multicatalytic proteinase complex by N‐acetylimidazole
40. Abnormal processing of multiple proteins in Alzheimer disease