JNK is involved in signal integration during costimulation of T lymphocytes

Cell

Volumn 77, Issue 5, 1994, Pages 727-736

  Su, Bing ^a   Jacinto, Estela ^a   Hibi, Masahiko ^a   Kallunki, Tuula ^a   Karin, Michael ^a   Ben Neriah, Yinon ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CD28 ANTIGEN; CD3 ANTIGEN; CYCLOSPORIN A; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; POLYCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ARTICLE; COMPETITIVE INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; NORTHERN BLOTTING; ONCOGENE C FOS; ONCOGENE C JUN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION;

EID: 0028291525     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90056-6     Document Type: Article

References (59)

1. The role of Jun Fos and the AP-1 complex in cell-proliferation and transformation
2. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
3. The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1
4. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
5. ERKs a family of protein serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
6. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulates its DNA-binding activity
7. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer
8. Contingent genetic regulatory events in T lymphocyte activation
9. The primary structure of MEK a protein kinase that phosphorylates the ERK gene product
10. JunB differs from c-Jun in its DNA-binding and dimerization domains and represses c-Jun by formation of inactive heterodimers
11. JNK1 A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
12. Stimulation of p21 ras upon T-cell activation
13. Characterization of antigen receptor response elements within the interleukin-2 enhancer
14. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
15. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
16. Phosphorylation of p62TCF by MAP kinase stimulates termary complex formation at c-Fos promoter
17. Cyclosporin A-mediated inhibition of mitogen-induced gene transcription is specific for the mitogenic stimulus and cell type
18. Monoclonal antibodies identifying a novel T-cell antigen and in antigens of human lymphocytes
19. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
20. The initiation of human T lymphocyte activation
21. Nuclear factor of activated T cells contains Fos and Jun
22. p is a substrate for calcineurin and interacts with Fos and Jun
23. Signals and signs for lymphocyte responses
24. Role of the CD28 receptor in T-cell activation
25. Transactivation by AP-1 is a molecular target of T cell clonal anergy
26. Raf-1 activates MAP kinase kinase
27. NF-κB a pleiotropic mediator of inducible and tissue-specific gene control
28. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity
29. The role of the CD28 receptor during T cell responses to antigen
30. The SRF accessory protein ELS-1 contains a growth factor regulated transcription domain
31. The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes
32. p, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs
33. When worlds collide immunosuppressants meet protein phosphatases
34. Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1
35. Clonal expansion versus functional clonal inactivation a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
36. Characterization of the nuclear and cytoplasmic components of the lymphoidspecific nuclear factor of activated T cells (NF-AT) complex
37. G1 events and regulation of cell proliferation
38. Phosphorylation of c-jun mediated by MAP kinases
39. Signalling mechanisms in T cell
40. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade
41. A vector for expressing GAL4 (1–147) fusions in mammalian cells
42. Platelet-derived growth factor stimulates formation of active p21ras-GTP complex in Swiss mouse 3T3 cells
43. Immunophilin-sensitive protein phosphatase action in cell signaling pathways
44. A cell culture model for T lymphocyte clonal anergy
45. Costimulation of T lymphocytes the role of CD28 CTLA-4 and B7/BB1 in interleukin-2 production and immunotherapy
46. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T-lymphocytes
47. Identification of a putative regulator of early T cell activation genes
48. Phosphorylation of c-Jun on serines 63 and 73 is required for oncogenic and transcriptional cooperation with Ha-Ras
49. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
50. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes
51. The serum response element
52. 40
53. Jun family members are controlled by a calcium-regulated cyclosproin A-sensitive signalling pathway in activated T lymphocytes
54. OKT3 a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties
55. Signal transduction by lymphocyte antigen receptors
56. v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase
57. ras mediates nerve growth factor receptor modulation of three signaltransducing protein kinases MAP kinase Raf-1 and RSK
58. Elevation of AP-1 activity during F9 cell differentiation is due to increased c-jun transcription
59. Complexity of the primary genetic response to mitogenic activation of human T cells