Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus iuterleukin 4 and downregulated by tumor necrosis factor α

Journal of Experimental Medicine

Volumn 179, Issue 4, 1994, Pages 1109-1118

  Sallusto, Federica ^a   Lanzavecchi, Antonio ^b  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; DENDRITIC CELL; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DOWN-REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMAN; INTERLEUKIN-4; PHENOTYPE; RECEPTORS, IGG; SOLUBILITY; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR;

EID: 0028289244     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.179.4.1109     Document Type: Article

References (38)

1. Barberis, A., K. Widenhom, L. Vitelli, and M. Busslinger. 1990. A novel B-cell lineage specific transcription factor present at early but not late stages of differentiation. Genes & Dev. 4:849.
2. Kozmik, Z., S. Wang, P. Dörfler, B. Adams, and M. Busslinger. 1992. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell Biol. 12:2662.
3. Okabe, T., T. Watanabe, and A. Kudo. 1992. A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreBi gene. Eur. J. Immunol. 22:37.
4. Liao, F., S.L. Giannini, and B.K. Birshtein. 1992. A nuclear DNA-binding protein expressed during early stages of B cell differentiation interacts with diverse segments within and 3' of the lg H chain gene cluster, J. Immunol. 148:2909.
5. Waters, S.H., K.U. Saikh, and J. Stavnezer. 1989. A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation. Mol. Cell. Biol. 9:5594.
6. Xu, L., M.G. Kim, and K.B. Marcu. 1992. Properties of B cell stage specific and ubiquitous nuclear factors binding to immunoglobulin heavy chain gene switch regions. Int. Immunol. 4:875.
7. Singh, M., and Birshtein, B.K. 1993. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3’α enhancer at early stages of B cell differentiation. Mol. Cell. Biol. 13:3611.
8. Neurath, M.F., W. Strober, and Y. Wakatsuki. 1994. The murine immunoglobulin 3’α enhancer is a target site with repressor function for the B-cell lineage-specific transcription factor BSAP (NF-HB, Sa-BP). J. Immunol. In press.
9. Adams, B., P. Dörfler, A. Aguzzi, Z. Kozmik, P. Urbanek, I. Maurer-Fogy, and M. Busslinger. 1992. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes & Dev. 6:1589.
10. Grass, P., and C. Walther. 1992. Pax in development. Cell. 69:719.
11. Stapleton, P., A. Weith, P. Urbanek, Z. Kozmik, and M. Busslinger. 1993. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nature Genetics. 3:292.
12. Walther, C., J.L. Guenet, D. Simon, U. Deutsch, B. Jostes, M.D. Goulding, D. Plachov, R. Balling, and P. Grass. 1991. Pax: a murine multigene family or paired box-containing genes. Genomics. 11:424.
13. Czerny, T., G. Schaffner, and M. Busslinger. 1993. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes & Dev. 7:2048.
14. Dressier, G.R., and E.C. Douglass. 1990. Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl. Acad. Sei. USA. 89:1179.
15. Kozmik, Z., R. Kurzbauer, P. Dörfler, and M. Busslinger. 1993. Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol. Cell. Biol. 13:6024.
16. Asano, M., and P. Grass. 1992. Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech. Dev. 39:29.
17. + normal B cells. Immunol. Rev. 93:35.
18. Peltz, G.A., M.L. Trounstine, and K.W. Moore. 1988. Cloned and expressed human Fc receptor for OgG mediated anti-CD3-dependent lymphoprolifération. J. Immunol. 141:1891.
19. Armitage, R.J., W.C. Fanslow, L. Stockbine, T.A. Sato, K.N. Clifford, B.M. Macduff, D.M. Anderson, S.D. Gimpel, T.D. Smith, C.R. Maliszewski, et al. 1992. Molecular and biological characterization of a murine ligand for CD40. Nature (Lond.). 357:80.
20. Schreiber, E., P. Matthias, M.M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with ‘miniextracts’, prepared from a small number of cells. Nucleic Acids. Res. 17:6419.
21. Bradford, M.M. 1976. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
22. Wakatsuki, Y., and W. Strober. 1993. Effect of downregula-tion of germline transcripts on immunoglobulin isotype differentiation. J. Exp. Med. 178:129.
23. Karasuyama, H., N. Tohyama, and T. Tada. 1989. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp Med. 169:13.
24. Graziadei, L-, P- Burfeind, and D. Bar-Sagi. 1991. Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluores-cein isothiocyanate as a marker for protein uptake. Anal. Biochem. 194:198.
25. Glogauer, M., and C.A.G. McCulloch. 1992. Introduction of large molecules into viable fibroblasts by electroporation: optimization of loading and identification of labeled cellular compartments. Exp Cell Res. 200:227.
26. Barberis, A., G. Superti-Furga, L. Vitelli, I. Kemler, and M. Busslinger. 1989. Development and tissue-specific regulation of a novel transcription factor of the sea urchin. Genes & Dev. 3:663.
27. Carter, R.H., and D.T. Fearon. 1992. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science (Wash. DC). 256:105.
28. Wagner, R.W., M.D. Matteucci, J.G. Lewis, A.J. Gutierrez, C. Moulds, and B.C. Froehler. 1993. Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science (Wash. DC). 260:1510.
29. Holt, J.T., T. Venkat-Gopal, A.D. Moulton, and A.W. Nienhuis. 1986. Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc. Natl. Acad. Sci. USA. 83:4794.
30. Nishikura, K., and J.M. Murray. 1987. Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells. Mol. Cell. Biol. 7:639.
31. Loke, S.L., C. Stein, X. Zhang, M. Avigen, J. Chen, and L.M. Neckers. 1988. Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematopoietic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis. Curr. Top. Microbiol. Immunol. 141:282.
32. Voltieri, M., D. Venturelli, A. Care, C. Fossati, E. Pelosi, C. Labbaye, G. Mathia, A.M. Gewirtz, B. Calabretta, and C. Pesche. 1991. Antisense myb inhibition of purified erythroid progenitors in development and differentiation is linked to cy-clin activity and expression of DNA polymerase 1. Blood. 77:1181.
33. Venturelli, D., S. Travali, and B. Calabretta. 1990. Inhibition of T-cell proliferation of a myb antisense oligomer is accompanied by selective down-regulation of DNA polymerase a expression. Proc. Natl. Acad. Sei. USA. 87:5963.
34. Heikkila, R., G. Schwab, E. Wickstrom, S.L. Loke, D.H. Pluznik, R. Watt, and L.M. Neckers. 1987. A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from GO to Gl. Nature (Lorid.). 328:445.
35. Maulbecker, C.C., and P. Gruss. 1993. The oncogenic potential of Pax genes. EMBO (Eur. Mol. Biol. Organ.) J. 12:2361.
36. Severinson-Gronowicz, E., C. Doss, andj. Schröder. 1979. Activation to IgG secretion by lipopolysaccharide requires several proliferative cycles. J. Immunol. 123:2057.
37. Dunnick, W., M. Williams, andj. Stavnezer. 1989. Mutation, duplication and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy chain switch. Mol. Cell. Biol. 9:1850.
38. Lee, W, A. Haslinger, M. Karin, and R. Tijan. 1987. Activation of transcription by two factors that bind promoter and enhancer of the human metallothionein gene. Nature (Lond.). 325:368.