Chiral manipulation of drug selectivity: Studies on a series of terfenadine-derived dual antagonists on H1-receptors and calcium channels

Agents and Actions

Volumn 41, Issue 1 Supplement, 1994, Pages

  Zhang, M Q ^a   Caldirola, P ^a   Timmerman, H ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BENZHYDRYL DERIVATIVE; BUTANOL; CALCIUM CHANNEL; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; TERFENADINE;

ANIMAL TISSUE; AORTA; CHEMICAL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SELECTIVITY; GUINEA PIG; HYDROPHILICITY; ILEUM; LIPOPHILICITY; LUNG; MEMBRANE; NONHUMAN; RAT; STEREOCHEMISTRY;

ANIMAL; CALCIUM CHANNEL BLOCKERS; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; ILEUM; IN VITRO; LIPIDS; LUNG; MOLECULAR CONFORMATION; MUSCLE, SMOOTH, VASCULAR; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TERFENADINE;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0028286704     PISSN: 00654299     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/BF02007802     Document Type: Article

References (4)

1. Terfenadine: the first nonsedating antihistamine
2. Calcium antagonism and structure-activity relationships of terfenadine, a histamine H1 antagonist, and some related compounds
3. Structure-activity relationships within a series of analogues of histamine H1-antagonist terfenadine
4. Novel stereoselective calcium channel ligands of the diphenylalkylamine-type