Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo

Journal of Medicinal Chemistry

Volumn 37, Issue 12, 1994, Pages 1810-1822

  O'Brien, Patrick M ^a   Sliskovic, Drago R ^a   Blankley, C John ^a   Roth, Bruce D ^a   Wilson, Michael W ^a   Hamelehle, Katherine L ^a   Krause, Brian R ^a   Stanfield, Richard L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; UREA DERIVATIVE;

ARTICLE; CHOLESTEROL BLOOD LEVEL; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; SOLUBILITY; STRUCTURE ACTIVITY RELATION;

AMIDES; AMINES; ANIMAL; ANTICHOLESTEREMIC AGENTS; CARBAMATES; DISEASE MODELS, ANIMAL; RABBITS; RATS; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 0028286581     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00038a010     Document Type: Article

References (12)

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2. Preliminary accounts of this work were presented at the 201st National ACS Meeting, Atlanta, GA, April 14-19,1991, MEDI 119, 120
3. 203rd National ACS Meeting, San Francisco, CA, April 5-10, 1992, MEDI 140
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