The future of biologies in the treatment of rheumatoid arthritis

Seminars in Arthritis and Rheumatism

Volumn 23, Issue 6 SUPPL. 2, 1994, Pages 50-58

  Koopman, William J ^a,b  

^a University of Alabama at Birmingham   (United States)

^b Rheumatology Research Service Department of Veterans Affairs Medical Center cyBirmingham AL UK ^*

Author keywords

biologies; Rheumatoid arthritis

Indexed keywords

AUTOIMMUNITY; BIOLOGICAL THERAPY; CELL HYPERPLASIA; CHRONIC INFLAMMATION; CONFERENCE PAPER; IMMUNE RESPONSE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE;

ANIMAL; ARTHRITIS, RHEUMATOID; BIOLOGICAL RESPONSE MODIFIERS; CELL DIVISION; HUMAN; MICE; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 0028286529     PISSN: 00490172     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-0172(94)90085-X     Document Type: Article

References (84)

1. Arthritis and autoimmunity in animals
2. Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4
3. Immunotherapy for myasthenia gravis: a murine model.
4. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker
5. Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice
6. + T-cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody
7. Inhibition of autoimmune uveitis by anti-CD4 antibody
8. 1 mice by treatment with monoclonal antibody to L3T4
9. In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.
10. Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein
11. Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen–Ia complex
12. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
13. s molecules
14. Rheumatoid Arthritis
15. Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes
16. + T-cells in synovial fluid and tissue of patients with rheumatoid arthritis
17. Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis
18. Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.
19. The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
20. HLA Genes associated with rheumatoid Arthritis. Identification of susceptibility alleles using specific oligonucleotide probes
21. The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis
22. Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.
23. Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjögren's syndrome
24. Lymphocyte Involvement in Rheumatoid Arthritis
25. Characterization of T-Cell Receptor alphabeta Repertoire in Synovial Tissue from Different Temporal Phases of Rheumatoid Arthritis
26. T cell receptor expression in early rheumatoid synovium
27. Etiology and pathogenesis of rheumatoid arthritis
28. Immunohistological features of synovitis in ankylosing spondylitis: a comparison with rheumatoid arthritis.
29. Abnormal Helper-Inducer/Suppressor-Inducer T-Cell Subset Distribution and T-Cell Activation Status are Common to All Types of Chronic Synovitis
30. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.
31. Regulated expression and binding of three VLA (β1) integrin receptors on T cells
32. The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion
33. VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes
34. Functional and Phenotypical Characterization of Activated T Cells from Intra-articular Sites in Inflammatory Joint Diseases.
35. Activated T cells in vivo and in vitro: Divergence in expression of Tac and Ia antigens in the nonblastoid small T cells of inflammation and normal T cells activated in vitro
36. How important are t cells in chronic rheumatoid synovitis?
37. 1992 and All That
38. Do nonimmunologically mediated pathways play a role in the pathogenesis of rheumatoid arthritis?
39. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
40. A spontaneous rheumatoid arthritis-like disease in MRL/l mice
41. Experimental murine systemic lupus erythematosus
42. Electron Microscopic Studies of Lymphoid Cells in the Rheumatoid Synovial Membrane
43. RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATION
44. Etiopathogenesis of the rheumatoid arthritis–like disease in MRL/1 mice. I. The histomorphologic basis of joint destruction
45. Immunohistochemical characterization of synovial cells in arthritic mrl-lpr/lpr mice
46. Etiopathogenesis of rheumatoid arthritis-like disease in MRL/1 mice: II. Ultrastructural basis of joint destruction.
47. Expression of the Collagenolytic and Ras-Induced Cysteine Proteinase Cathepsin L and Proliferation-Associated Oncogenes in Synovial Cells of MRL/I Mice and Patients with Rheumatoid Arthritis
48. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts
49. Expression of collagenase and potential transcriptional factors in the MRL/1 mouse arthropathy
50. Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats
51. Hyperplastic synoviocytes from rats with streptococcal cell wall-induced arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable
52. Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
53. Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritis joints
54. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.
55. Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats.
56. Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats.
57. Inhibition by cyclosporin A of streptococcal cell wall-induced arthritis and hepatic granulomas in rats
58. Destructive arthritis without lymphocyte infiltration in H2-c-fos transgenic mice.
59. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters
60. Immune function in severe, active rheumatoid arthritis. A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics.
61. Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis
62. Rheumatoid arthritis
63. Histomorphological Basis of Articular Cartilage Destruction in Rheumatoid Arthritis
64. Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis.
65. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1.
66. Transforming Growth Factor-? in Rheumatoid Arthritis
67. Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids
68. COLLAGENASE PRODUCTION BY HUMAN SYNOVIAL TISSUES
69. Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium
70. Characterization of collagenase, other metallo-proteinases and an inhibitor (TIMP) produced by human synovium and cartilage in culture.
71. Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis
72. Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA
73. Integrins: Versatility, modulation, and signaling in cell adhesion
74. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
75. Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.
76. Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells.
77. Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin E2.
78. Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1
79. INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS
80. Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis
81. Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-γ and tumor necrosis factor-α
82. Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products.
83. Differential patterns of response to treatment with an anti-CD5 immunoconjugate in patients with rheumatoid arthritis
84. New Approaches to the Therapy of Autoimmune Diseases