DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1

Journal of Cell Biology

Volumn 125, Issue 3, 1994, Pages 625-638

  Lukas, Jiri ^a   Müller, Heiko ^a,b   Bartkova, Jirina ^a   Spitkovsky, Dimitry ^c   Kjerulff, Anne A ^a   Jansen Dürr, Pidder ^c   Strauss, Michael ^a,b   Bartek, Jiri ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b MAX PLANCK INSTITUTE   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; MESSENGER RNA; ONCOPROTEIN; VIRUS LARGE T ANTIGEN;

ADENOVIRUS; ARTICLE; CELL CYCLE; CELL DIVISION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINOBLASTOMA; SIMIAN VIRUS 40; TUMOR SUPPRESSOR GENE;

EID: 0028279059     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.125.3.625     Document Type: Article

References (73)

1. Baldin, V., J. Lukas, M. J. Marcote, M. Pagano, and G. Draetta. 1993. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes & Dev. 7:812-821.
2. Bandara, L. R., and N. B. LaThangue. 1991. Adenovirus E1A prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Nature (Lond.). 351:494-497.
3. Bartek, J., J. Bartkova, N. Kyprianou, E.-N. Lalani, Z. Staskova, M. Shearer, S. Chang, and J. Taylor-Papadimitriou. 1991. Efficient immortalization of Iuminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus. Proc. Natl. Acad. Sci. USA. 88:3520-3524.
4. Bartek, J., B. Vojtesek, R. J. A. Grand, P. H. Gallimore, and D. P. Lane. 1992. Cellular localization and T antigen binding of the retinoblastoma protein. Oncogene. 7:101-108.
5. Bartek, J., Z. Staskova, G. Draetta, and J. Lukas. 1993a. Molecular pathology of the cell cycle in human cancer cells. Stem Cells. 11(Suppl. 1):51-58.
6. Bartek, J., B. Vojtesek, and D. P. Lane. 1993b. Diversity of human p53 mutants revealed by complex formation to SV40 T antigen. Eur. J. Cancer. 29A:101-107.
7. Bartkova, J., J. Lukas, M. Strauss, and J. Bartek. 1994. Cell cycle-related variation and tissue-restricted expression of cyclin D1 protein. J. Pathol. In press.
8. Buchkovich, K., L. A. Duffy, and E. Harlow. 1989. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell. 58: 1097-1105.
9. Buchou, T., O. Kranenburg, H. van Dam, D. Roelen, A. Zantema, F. L. Hall, and A. van der Eb. 1993. Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. Oncogene. 8:1765-1773.
10. Casey, G., M. Lo-Hsueh, M. E. Lopez, B. Vogelstein, and E. J. Stanbridge. 1991. Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene. Oncogene. 6:1791-1797.
11. Chellapan, S. P., S. Hiebert, M. Mudryj, J. M. Horowitz, and J. R. Nevins. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell. 65:1053-1061.
12. Chittenden, T., D. M. Livingston, and W. Kaelin. 1991. The T/E1A binding domain of the retinoblastoma gene product can interact selectively with a sequence-specific DNA-binding protein. Cell. 65:1073-1082.
13. Cobrinik, D., S. F. Dowdy, P. W. Hinds, S. Mittnacht, and R. A. Weinberg. 1992. The retinoblastoma protein and the regulation of cell cycling. Trends Biochem. Sci. 17:312-315.
14. DeCaprio, J. A., J. W. Ludlow, J. Figge, J.-Y. Shew, C.-M. Huang, W.-H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell. 54:275-283.
15. Dobbelstein, M., A. K. Arthur, S. Dehde, K. van Zee, A. Dickmanns, and E. Fanning. 1992. Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells. Oncogene. 7:837-847.
16. Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg. 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell. 73:499-511.
17. Dyson, N., and E. Harlow. 1992. Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv. 12:161-195.
18. Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (Wash. DC). 243:934-937.
19. Ewen, M. E., Y. Xing, J. B. Lawrence, and D. M. Livingston. 1991. Molecular cloning, chromosomal mapping and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell. 58:1155-1164.
20. Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushime, J.-Y. Kato, and D. M. Livingston. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell. 73:487-497.
21. cdk2. J. Virol. 67:2456-2465.
22. Fanning, E. 1992. Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J. Virol. 66:1289-1293.
23. Fattaey, A. R., E. Harlow, and K. Helin. 1993. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mo1. Cell Biol. 13:7267-7277.
24. Giordano, A., P. Whyte, E. Harlow, B. R. Franza, D. Beach, and G. Draetta. 1989. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell. 58:981-990.
25. Goodrich, D. W., and W.-H. Lee. 1993. Molecular characterization of the retinoblastoma susceptibility gene. Biochim. Biophys. Acta. 1155:43-61.
26. Harlow, E., B. R. Franza, and C. Schley. 1985. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol. 55:533-546.
27. Helin, K., J. A. Lees, M. Vidai, N. Dyson, E. Harlow, and A. Fattaey. 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 70:337-350.
28. Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell. 70:993-1006.
29. Horowitz, J. M., S.-H. Park, E. Bogenmann, J.-C. Cheng, D. W. Yandell, F. J. Kaye, J. D. Minna, T. P. Dryja, and R. A. Weinberg. 1990. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc. Natl. Acad. Sci. USA. 87:2775-2779.
30. Hu, Q., N. Dyson, and E. Harlow. 1990. Regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 Large T antigen are common sites for mutations. EMBO (Eur. Mol. Biol. Organ.) J. 9:1147-1155.
31. Huang, S., N.-P. Wang, B. Y. Tseng, W.-H. Lee, and E. Y.-H. P. Lee. 1990. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO (Eur. Mol. Biol. Organ.) J. 9:1815-1822.
32. Huang, S., W.-H. Lee, and E. Y. H.-P. Lee. 1991. A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product. Nature (Lond.). 350:160-162.
33. Imai, Y., Y. Matsushima, T. Sugimura, and M. Terada. 1991. Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product. J. Virol. 65:4966-4972.
34. Kaelin, W. G., M. E. Ewen, and D. M. Livingston. 1990. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell Biol. 10:3761-3769.
35. Kaelin, W. G., D. C. Pallas, J. A. De Caprio, F. J. Kaye, and D. M. Livingston. 1991. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell. 64:521-532.
36. Kato, J.-Y., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes & Dev. 7:331-342.
37. Lammie, G., V. Fantl, R. Smith, E. Schuuring, S. Brookes, R. Michalides, C. Dickson, A. Arnold, and G. Peters. 1991. D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BC1-1. Oncogene. 6:439-444.
38. Lee, E. Y.-H. P., H. To, J.-Y. Shew, R. Bookstein, P. Scully, and W.-H. Lee. 1988a. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science (Wash. DC). 241:218-221.
39. Lee, E. Y.-H. P., R. Bookstein, L.-J. Young, C.-J. Lin, M. G. Rosenfeld, and W.-H. Lee. 1988b. Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79. Proc. Natl. Acad. Sci. USA. 85: 6017-6021.
40. Lees, J. A. K., J. Buchkovich, D. R. Marshak, C. W. Anderson, and E. Harlow. 1991. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO (Eur. Mol. Biol. Organ.) J. 10:4279-4290.
41. Lees, E., B. Faha, V. Dulic, S. I. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes & Dev. 6:1874-1885.
42. Lew, D. J., V. Dulic, and S. I. Reed. 1991. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. 66:1197-1206.
43. Ludlow, J. W., J. A. DeCaprio, C.-M. Huang, W.-H. Lee, E. Paucha, and D. M. Livingston. 1989. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell. 56:57-65.
44. Lukas, J., M. Pagano, Z. Staskova, G. Draetta, and J. Bartek. 1994. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene. 9:707-718.
45. Matsushime, H., M. F. Roussel, R. A. Ashmun, and C. J. Sherr. 1991. Colonystimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 65:701-713.
46. PSK+13/cdk4) for mammalian D type G1 cyclins. Cell. 71:323-334.
47. Motokura, T., and A. Arnold. 1993. Cyclins and oncogenesis. Biochim. Biophys. Acta. 1155:63-78.
48. Motokura, T., T. Bloom, H. G. Kim, H. Juppner, J. V. Ruderman, H. M. Kronenberg, and A. Arnold. 1991. A novel cyclin encoded by a bc11-linked candidate oncogene. Nature (Lond.). 350:512-515.
49. Motokura, T., K. Keyomarsi, H. M. Kronenberg, and A. Arnold. 1992. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. J. Biol. Chem. 267: 20412-20415.
50. Mudryj, M., S. Devoto, S. Hiebert, T. Hunter, J. Pines, and J. R. Nevins. 1991. Cell cycle regulation of the E2F transcription factor involves an niteraction with cyclin A. Cell. 65:1243-1253.
51. Müller, H., J. Lukas, A. Schneider, P. Wathoe, J. Bartek, M. Eilers, and M. Strauss. 1994. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA. In press.
52. Munger, K., M. Scheffner, J. M. Huibregtse, and P. M. Howley. 1992. Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. Cancer Surv. 12:197-217.
53. Musgrove, E. A., J. A. Hamilton, C. S. L. Lee, K. J. E. Sweeney, C. K. V. Watts, and R. L. Sutherland. 1993. Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol. Cell Biol. 13:3577-3587.
54. Nevins, J. R. 1992. E2F; a link between the Rb tumor suppressor protein and viral oncogenesis. Science (Wash. DC). 258:424-429.
55. Norbury, C., and P. Nurse. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61:441-470.
56. Pagano, M., G. Draetta, and P. Jansen-Durr. 1992a. Association of cdk2 kinase with the transcription factor E2F during S phase. Science (Wash. DC). 255:1144-1147.
57. Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta. 1992b. Cyclin A is required at two points in the human cell cycle. EMBO (Eur. Mol. Biol. Organ.) J. 11:761-771.
58. Pardee, A. B. 1989. G1 events and regulation of cell proliferation. Science (Wash. DC). 246:603-608.
59. Pines, J., and T. Hunter. 1990. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (Lond.). 346: 760-763.
60. Quelle, D. E., R. A. Ashmun, S. A. Shurtleff, J.-Y. Kato, D. Bar-Sagi, M. F. Roussel, and C. J. Sherr. 1993. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes & Dev. 7:1559-1571.
61. Scheffner, M., K. Munger, J. C. Byrne, and P. M. Howley. 1991. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA. 88:5523-5527.
62. Schwarz, J. K., S. H. Devoto, E. J. Smith, S. P. Chellapan, L. Jakoi, and J. R. Nevins. 1993. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO (Eur. Mol. Biol. Organ.) J. 12: 1013-1020.
63. Sewing, A., C. Burger, S. Brusselbach, C. Schalk, F. C. Lucibello, and R. Muller. 1993. Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly regulated by serum growth factors. J. Cell Sci. 104:545-554.
64. Sherr, C. J. 1993. Mammalian G1 cyclins. Cell. 73:1059-1065.
65. Shew, J.-Y., B. T.-Y. Lin, P.-L. Chen, B. Y. Tseng, T. L. Yang-Feng, and W.-H. Lee. 1990. C-terminal truncation of the retinoblastoma gene product leads to functional inactivation. Proc. Natl. Acad. Sci. USA. 87:6-10.
66. Shirodkar, S., M. Ewen, J. DeCaprio, J. Morgan, D. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 68:157-166.
67. Stratton, M. R., S. Moss, W. Warren, H. Patterson, J. Clark, C. Fisher, C. D. M. Fletcher, A. Ball, M. Thomas, B. A. Gusterson, and C. S. Cooper. 1990. Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene. Oncogene. 5:1297-1301.
68. Strauss, M., S. Hering, A. Lieber, G. Herrmann, B. E. Griffin, and W. Arnold. 1992. Stimulation of cell division and fibroblast focus formation by antisense repression of retinoblastoma protein synthesis. Oncogene. 7:769-773.
69. T'Ang, A., J. M. Varley, S. Chakraborty, A. L. Murphree, and T.-K. T. Fung. 1988. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science (Wash. DC). 242:263-266.
70. von Knebel Doeberitz, M., T. Bauknecht, D. Bartsch, and H. Zur Hausen. 1991. Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells. Proc. Natl. Acad. Sci. USA. 88:1411-1415.
71. Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Association between an oncogene and an antioncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (Lond.). 334:124-129.
72. Xiong, Y., T. Connolly, B. Futcher, and D. Beach. 1991. Human D-type cyclin. Cell. 65:691-699.
73. Xiong, Y., H. Zhang, and D. Beach. 1992. D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell. 71:505-514.