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Volumn 4, Issue 3, 1994, Pages 337-344

RNA pseudoknots

Author keywords

[No Author keywords available]

Indexed keywords

REPRESSOR PROTEIN; RIBOSOME PROTEIN; RIBOSOME RNA; RIBOZYME; SINGLE STRANDED DNA; TRANSFER RNA; VIRUS RNA;

EID: 0028277765     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(94)90101-5     Document Type: Article
Times cited : (54)

References (45)
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    • of outstanding interest, A very extensive mutational analysis of the pseudoknot stalk in the 3′ UTR of TMV RNA. We will certainly hear more about this system in the future and it will be most interesting to know how these pseudoknots mimic the polyA tail of cellular messenger RNA. The psudoknot is compared with the ‘neighbouring’ tRNA-like structure, and possibly represents another example of conformational mimicry.
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    • of special interest, This paper shows us that polyadenylated viral RNAs can also harbour pseudoknotted structures in their 3′ untranslated region. A direct role in the process of viral replication seems to be likely, but the story of plant viral RNAs tells us to be cautious before hypothesizing about a possible function for this pseudoknot.
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    • of special interest, Like the previous paper, 221, this study strongly fosters the idea that pseudoknotted structures are a fundamental structural motif in this ancient molecule. These pseudoknots in the core of the 16S ribosomal RNA are built from heavily conserved regions suggesting that they have played a fundamental role in protein biosynthesis from the very beginning. It will be interesting to see whether further experimentation will confirm the idea of pseudoknots as conformational switches. switches paper is also valuable for those who want to know more about the merits of the ‘specialized ribosome’ system.
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    • of special interest, Apart from dealing with the most complex pseudoknot structure described so far, this paper is also one of the better examples of a detailed study of the structure-function relationship of an RNA pseudoknot.
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    • of special interest, A nice example of how evidence is obtained for a pseudoknot as a stimulator in frameshifting. It also shows us that we always have to be aware of the existence of pseudoknots that are more complex than simply two stems and two (short) connecting loops.
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    • RNA Pseudoknots that Inhibit Immunodeficiency Virus Type 1 Reverse Transcriptase
    • of outstanding interest, The identification of pseudoknotted structures as the winning structural motif for binding to the reverse transcriptase has wide implications for the way in which we have to appreciate pseudoknotted structures. Apparently, RNA pseudoknots are ideal structures for protein binding. I bet that loop L2, spanning the minor groove and probably having its base residues exposed, is in fact doing the trick. Pseudoknot formation is probably one of the few ways to destack or expose a stretch of base residues.
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    • Tuerk1    MacDougal2    Gold3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.