Morphological and immunochemical differences between keloid and hypertrophic scar

American Journal of Pathology

Volumn 145, Issue 1, 1994, Pages 105-113

  Ehrlich, H Paul ^a   Desmoulière, Alexis ^b,f   Diegelmann, Robert F ^c   Cohen, I Kelman ^c   Compton, Carolyn C ^d   Garner, Warren L ^e   Kapanci, Yusuf ^b   Gabbiani, Giulio ^b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^f CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; COLLAGEN FIBER;

ARTICLE; COLLAGEN METABOLISM; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERTROPHIC SCAR; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KELOID; MICROSCOPY; MYOFIBROBLAST; PRIORITY JOURNAL;

ACTINS; ADOLESCENT; ADULT; CHILD; CICATRIX, HYPERTROPHIC; COLLAGEN; FIBROBLASTS; HUMANS; KELOID; MICROSCOPY, ELECTRON;

EID: 0028276663     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Boykin JV, Molnar JA: Burn scars and skin equivalents. Wound Healing: Biochemical and Clinical Aspects. Edited by Cohen IK, Diegelmann RF, Lindblad WJ. Philadelphia, WB Saunders Co., 1992, pp 523-540
2. Peacock EE, Maddem JW, Trier WC: Biological basis for the treatment of keloids and hypertrophic scars. South Med J 1970, 63:755-859
3. Lawrence WT: In search of the optimal treatment of keloids: report of a series and review of the literature. Ann Plast Surg 1991, 27:164-178
4. Kischer CW, Shetlar MR, Chvapil M: Hypertrophic scars and keloids: a review and new concept concerning their origin. Scand Elect Micro 1982, 4:1699-1713
5. Rockwell WB, Cohen IK, Ehrlich HP: Keloids and hypertrophic scars: a comprehensive review. Plast Reconstr Surg 1989, 84:827-837
6. Blackburn WR, Cosman C: Histologic basis of keloid and hypertrophic scar differentiation. Arch Pathol 1966, 82:65-71
7. Linares HA, Kischer CW, Dobrkovsky M, Larson DL: The histiotypic organization of the hypertrophic scar in humans. J Invest Dermatol 1972, 59:323-331
8. Glucksmann A: Local factors in the histogenesis of hypertrophic scars. Br J Plast Surg 1951, 4:88-103
9. Gabbiani G, Majno G: Dupuytren's contracture: fibroblast contraction? Am J Pathol 1972, 66:131-138
10. Kischer CW, Brody GS: Structure of the collagen nodule from hypertrophic scars and keloids. Scand Elect Micro 1981, 3:371-376
11. Kischer CW: Fibroblasts of the hypertrophic scar, mature scar and normal skin: a study by scanning and transmission electron microscopy. Tex Rep Biol Med 1974, 32:699-709
12. Eddy RJ, Petro JA, Tomasek JJ: Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertrophic scar. An immunofluorescence study. Am J Pathol 1988, 130:252-260
13. Schürch W, Seemayer TA, Gabbiani G: Myofibroblast. Histology for Pathologists. Edited by SS Sternberg. New York, Raven Press, 1992, pp 109-144
14. Rungger-Brändle E, Gabbiani G: The role of cytoskeleton and cytocontractile elements in pathological processes. Am J Pathol 1983, 110:359-392
15. Grinnell F: Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol 1994, 124:401-404
16. Skalli O, Schürch W, Seemayer T, Lagace R, Montandon D, Pittet B, Gabbiani G: Myofibroblasts from diverse pathological settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 1989, 60:275-285
17. Darby I, Skalli O, Gabbiani G: α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990, 63: 21-29
18. Skalli O, Ropraz P, Treciak A, Benzonana G, Gillessen D, Gabbiani G: A monoclonal antibody against α-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986, 103:2787-2796
19. Tsukada T, McNutt MA, Ross R, Gown AM: HHF 35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. Am J Pathol 1987, 127:389-402
20. Welch MP, Odland GF, Clark RAF: Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J Cell Biol 1990, 110:133-145
21. Baur PS, Larson DL, Stacey TR: The observation of myofibroblasts in hypertrophic scars. Surg Gynecol Obstet 1975, 141:22-26
22. Constantine VS, Mowry RW: The selective staining of human dermal collagen: the use of picrosirius red F3BA with polarization microscopically. J Invest Dermatol 1968, :419-423
23. Lametschwandtner A, Staindl O: Angioarchitecture of keloids: a scanning electron microscopy study of a corrosion specimen. HNO 1990, 38:202-207
24. Singer II, Kawka DW, Kazazis DM, Clark RAF: In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface. J Cell Biol 1984, 98:2091-2106
25. Desmoulière A, Rubbia-Brandt L, Abdiu A, Walz T, Macieira-Coelho A, Gabbiani G: α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon. Exp Cell Res 1992, 201:64-73
26. Mancini RE, Quaife JW: Histogenesis of experimentally produced keloids. J Invest Dermatol. 1962, 38: 143-150
27. Gabbiani G, Schmid E, Winter S, Chaponnier C, de Chastonay C, Vandekerckhove J, Weber K, Franke WW: Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific α-type of actin. Proc Natl Acad Sci USA 1981, 78:298-302
28. Kischer CW, Thies AC, Chvapil M: Perivascular myofibroblasts and microvascular occlusion in hypertrophic scars and keloids. Hum Pathol 1982, 13:819-824
29. Hembry RM, Bernanke DH, Hayshi K, Trelstad RL, Ehrlich HP: Morphologic examination of mesenchymal cells in healing wounds of normal and tight skin mice. Am J Pathol 1986, 125:81-89
30. Desmoulière A, Geinoz A, Gabbiani F, Gabbiani G: Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993, 122:103-111
31. Andrew JG, Andrew SM, Ash A, Turner B: An investigation into the role of inflammatory cells in Dupuytren's disease. J Hand Surg [Br] 1991, 16B:267-271