Thymus independent T cell development and selection in the intestinal epithelium

Annual Review of Immunology

Volumn 12, Issue , 1994, Pages 521-553

  Poussier, Philippe ^a   Julius, Michael ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

extra thymic; intestine; T lymphopoiesis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; H2 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; DEVELOPMENT; INTESTINE LYMPHATIC TISSUE; LYMPHOPOIESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0028273754     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.iy.12.040194.002513     Document Type: Review

References (22)

1. Weber EM. 1847. Uber den Mechanisms der Einsaugung des Speisesaftes beim Menschen und beim einigen tieren. Arch. Anal. Physiol. Wiss. Med. pp. 400-402
2. Du Pasquier L. 1989. Evolution of the immune system. In Fundamental Immunology, ed. WE Paul, pp. 139-165. New York: Raven
3. Ferguson A, Parrott DMV. 1972. The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse. Clin. Exp. Immunol. 12: 477-88
4. Havran WL, Allison JP. Origin of thyl dendritic epidermal cells of adult mice from fetal thymic precursors. 1990. Nature 344: 68-70
5. Yoshikai Y, Ishida A, Murosaki S, Ando T, Nomoto K. 1991. Sequential appearance of T-cell receptor γδ-and αβ-bearing intestinal intra-epithelial lymphocytes in mice after irradiation. Immunology. 74: 583-88
6. - cells and high expression of the RT6 alloantigen. Eur. J. Immunol. 21: 753-60
7. Trejdosiewicz LK, Smart CJ, Oakes DJ, Howdle PD, Malizia G, Campana D, Boylston AW. 1989. Expression of T-cell receptors TcR1 (γ/δ) and TcR2 (α/β) in the human intestinal mucosa. Immunology 63: 7-12
8. + T cells by class II major histocompatibility complex molecules. Cell 63: 333-40
9. Lefrancois L. 1991. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147: 1746-51
10. Bandeira A, Mota-Santos T, Itohara S, Degermann S, Heusser C, Tonegawa S, Coutinho A. 1990. Localization of γ/δ T cells to the intestinal epithelium is independent of normal microbial colonization. J. Exp. Med. 172: 239-44
11. Cantor H, Boyse EA. 1975. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T cell subclasses is a differentiative process independent of antigen. J. Exp. Med. 141: 1376-89
12. Torres-Nagel N, Kraus E, Brown MH, Tiefenthaler G, Mitnacht R, Williams AF, Hunig T. 1991. Differential thymus dependence of rat CD8 isoform expression. Eur. J. Immunol. 22: 2841-48
13. Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JC, Ip S, Rosen F, Krangel MS. 1986. Identification of a putative second T-cell receptor. Nature 322: 145-49
14. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. 1991. CD4 expressed on earliest lineage precursor cells in the adult murine thymus. Nature 349: 71-74
15. Mayrhofer G, Whately RJ. Granular intraepithelial lymphocytes of the rat small intestine. I. Isolation, presence in T lymphocyte-deficient rats and hone marrow origin. Int. Archs. Allergy Appli. Immun. 71: 317-27
16. Bonneville M, Janeway CA Jr, Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S. 1988. Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 336: 479-81
17. Bandeira A, Itohara S, Bonneville M. Burlen-Defranoux O, Mota-Santos T, Coutinho A, Tonegawa S. 1991. Extra-thymic origin of intestinal intraepithelial lymphocytes hearing T-cell antigen receptor γδ. Proc. Natl. Acad. Sci. USA 88: 43-47
18. Mosley RL, Styre D, Klein JR. 1990. Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras. J. Immunol. 145: 1369-75
19. Poussier P, Edouard P, Lee C, Binnie M, Julius M. 1992. Thymus-independent development and negative selection of T cells expressing T cell receptor α/β in the intestinal epithelium: evidence for distinct circulation patterns of gut-and thymus-derived T lymphocytes. J. Exp. Med. 176: 187-99
20. Dunon D, Cooper MD, Imhof BA. 1993. Thymic origin of embryonic intestinal γ/δ T cells. J. Exp. Med. 177: 257-63
21. + lymphocyte populations with different T cell receptors: A role for the gut epithelium in T cell differentiation. J. Exp. Med. 173: 471-81
22. Mosley RL, Klein JR. 1993. Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: Direct evidence for thymopoietic function of murine small intestine. J. Exp. Med. 176: 1365-73