NS 257 (1,2,3,6,7,8-hexahydro-3(hydroxyimino)-N,N,7-trimethyl-2-oxobenzo[2,1-b: 3,4-c']dipyrrole-5-sulfonamide) is a potent, systemically active ampa receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 4, Issue 2, 1994, Pages 371-376

  Wätjen, Frank ^a   Bigge, Christopher F ^b   Jensen, Leif H ^a   Boxer, Peter A ^b   Lescosky, Leonard J ^b   Nielsen, Elsebet Ø ^a   Malone, Thomas C ^a   Campbell, Gregory W ^b   Coughenour, Linda L ^b   Rock, David M ^b   Drejer, Jorgen ^a   Marcoux, Frank W ^b  

^a NEUROSEARCH A S   (Denmark)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1,2,3,6,7,8 HEXAHYDRO 3 HYDROXYIMINO N,N,7 TRIMETHYL 2 OXOBENZO[2,1 B:3,4 C']DIPYRROLE 5 SULFONAMIDE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTICONVULSIVE AGENT; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLYCINE; KAINIC ACID; LACTATE DEHYDROGENASE; NS 257; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEIZURE;

EID: 0028269844     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80147-5     Document Type: Article

References (16)

1. The chemistry of isatin.