Effects of nicorandil on human isolated corpus cavernosum and cavernous artery

Journal of Urology

Volumn 151, Issue 4, 1994, Pages 1107-1113

  Hedlund, P ^a   Holmquist, F ^a   Hedlund, H ^a   Andersson, K E ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

nitric oxide; penile erection; potassium channels

Indexed keywords

CROMAKALIM; GLIBENCLAMIDE; LINSIDOMINE; NICORANDIL; POTASSIUM CHANNEL;

ADULT; AGED; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; ELECTROSTIMULATION; HUMAN; HUMAN TISSUE; IMPOTENCE; PENIS ARTERY; PENIS ERECTION; PRIORITY JOURNAL;

EID: 0028268046     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(17)35193-5     Document Type: Article

References (39)

1. G-nitroar-ginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated corpus cavernosum Acta Physiol. Scand. 141 1991 441
2. F. Holmquist H. Hedlund Κ-E. Andersson Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man J. Physiol. 449 1992 295
3. N. Kim K.M. Azadzoi I. Goldstein I. Saenz de Tejada A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle J. Clin. Invest. 88 1991 112
4. R.S. Pickard P.H. Powell M.A. Zar The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerveevoked relaxation of human cavernosal smooth muscle Br. J. Pharmacol. 104 1991 755
5. J. Rajfer W.J. Aronson P.A. Bush F.J. Dorey C.J. Ignarro Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission N. Engl. J. Med. 326 1992 90
6. K.-P. Junemann P. Alken Pharmacotherapy of erectile dys function: a review Int. J. Impotence Res. 1 1989 71
7. A. Giraldi G. Wagner Effect of pinacidil upon penile erectile tissue, in vitro and in vivo Pharmacol. Toxicol. 67 1990 235
8. F. Holmquist K.-E. Andersson H. Hedlund Effects of pin acidil on isolated human corpus cavernosum penis Acta Physiol. Scand. 138 1990 463
9. C.G. Stief F. Holmquist E.P. Allhoff K.-E. Andersson U. Jonas Preliminary report on the effect of the nitric oxide (NO) donor SIN-1 on human cavernous tissue in vivo World J. Urol. 9 1991 237
10. C.G. Stief F. Holmquist M. Djamilian H. Kräh K.-E. Andersson U. Jonas Preliminary results with the nitric oxide donor Linsidomine chlorhydrate in the treatment of human erectile dysfunction J. Urol. 148 1992 1437
11. Y. Uchida N. Yoshimoto S. Murao Effect of 2-nicotinami-doethyl nitrate (SG-75) on coronary circulation Jpn. Heart J. 19 1978 112
12. N. Taira K. Satoh T. Yanagisawa Y. Imai M. Hiwatari Pharmacological profile of a new coronary vasodilator drug, 2-nicotinamidoethyl nitrate (SG-75) Clin. Exp. Pharmacol. Physiol. 6 1979 301
13. W.J.G. Hellstrom R. Wang P.J. Kadowitz F.R. Domer Potassium channel agonists cause penile erection in cats Int. J. Impotence Res. 4 1992 35
14. K. Sakai Nicorandil: animal pharmacology Am. J. Cardiol. 63 1989 2J
15. J. Frampton M.M. Buckley A. Fitton Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris Drugs 44 1992 625
16. 86Rb flux studies in rabbit isolated vascular smooth muscle Naunyn-Schmeidebergs Arch. Pharmacol. 343 1991 70
17. 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle J. Cardiovasc. Pharmacol. 20 1992 S8
18. H. Zhang N. Stockbridge B. Weir B. Vollrath D. Cook Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim Gen. Pharmacol. 23 1992 197
19. K. Satoh H. Yamada N. Taira Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries Naunyn-Schmiedebergs Arch. Pharmacol. 343 1991 76
20. +-channel openers, and nicorandil on large and small coronary arteries in conscious dogs J. Cardiovasc. Pharmacol. 20 1992 S17
21. J.-L. Imagawa M. Akima H. Nabata N. Taira Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not mediated by glibenclamide J. Cardiovasc. Pharmacol. 19 1992 108
22. + channels and cyclic GMP as components of vasodilation by nicorandil Eur. J. Pharmacol. 215 1992 1
23. Hedlund, P., Holmquist, F., Hedlund, H. and Andersson, K.-E.: Effects of nicorandil on human isolated corpus cavernosum and cavernous artery. J. Urol., abstract 135, 149: 247A.
24. K.-E. Andersson F. Holmquist Mechanisms for contraction and relaxation of human penile smooth muscles Int. J. Impotence Res. 2 1990 209
25. H. Hedlund Κ-E. Andersson Comparison of the responses to drugs acting on adrenoceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery J. Auton. Pharmacol. 5 1985 81
26. F. Holmquist K.-E. Andersson H. Hedlund Actions of endothelin on isolated corpus cavernosum from rabbit and man Acta Physiol. Scand. 139 1990 113
27. F. Holmquist H.J. Kirkeby B. Larsson A. Forman P. Alm Κ-E. Andersson Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit J. Pharmacol. Exp. Ther. 261 1992 795
28. L. Saenz de Tejada M.P. Carson A. de las Morenas I. Goldstein A.M. Traish Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum Am. J. Physiol. 261 1991 H1078
29. +-channel openers for relaxation of isolated penile erectile tissue from rabbit J. Urol. 144 1990 146
30. W.R. Kukovetz S. Holzmann G. Pich Molecular mechanism of action of nicorandil J. Cardiovasc. Pharmacol. 20 1992 S1
31. K. Furukawa T. Itoh M. Kajiwara K. Kitamura H. Suzuki Y. Ito H. Kuriyama Vasodilating actions of 2-nicotinami-doethyl nitrate on porcine and guinea-pig coronary arteries J. Pharmacol. Exp. Ther. 218 1981 248
32. K. Sakai Y. Shiraki H. Nabata Cardiovascular effects of a new coronary vasodilator N-(2-hydroxyethyl) nicotinamide nitrate (SG-75): comparison with nitroglycerin and diltiazem J. Cardiovasc. Pharmacol. 3 1981 139
33. D.J. Lefer A.M. Lefer Studies on the mechanism of the vasodilator action of nicorandil Life Sei. 42 1988 1907
34. 2 formation by a new vasodilator, 2-nicotinamido-ethyl nitrate in the coupled system of platelets and aortic microsomes Prostaglandins 19 1980 577
35. 1 from ischemic areas in dogs with experimental myocardial infarction. Jpn Heart J. 23 1982 603
36. ++ entry in rabbit aorta J. Pharmacol. Exp. Ther. 233 1985 100
37. K. Murakami H. Karaki N. Urakawa Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta Eur. J. Pharmacol. 141 1987 192
38. 2+)-ATPase activity of vascular smooth muscle cells J. Cardiovasc. Pharmacol. 10 1987 S31
39. F. Holmquist M. Fridstrand H. Hedlund K.-E. Andersson Action of 3-morpholinosydninomin (SIN-1) on rabbit isolated penile erectile tissue J. Urol. 150 1993 1310