Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen

Journal of Virology

Volumn 68, Issue 4, 1994, Pages 2671-2676

  Yamamoto, Kayoko ^a   Horikita, Minoru ^b   Tsuda, Fumio ^c   Itoh, Keiichi ^d   Akahane, Yoshihiro ^e   Yotsumoto, Shigeru ^a   Okamoto, Hiroaki ^a   Miyakawa, Yuzo ^f   Mayumi, Makoto ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c Viral Hepatitis Foundation of Japan   (Japan)

^d Japan Red Cross Yamaguchi Blood C   (Japan)

^e UNIVERSITY OF YAMANASHI   (Japan)

^f Mita Institute   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE DELETION; GENE INSERTION; HEPATITIS B VIRUS; HUMAN; MALE; POINT MUTATION; PRIORITY JOURNAL; SEROCONVERSION; SERUM; VIRUS CARRIER; VIRUS MUTANT; VIRUS TRANSMISSION;

EID: 0028265185     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.68.4.2671-2676.1994     Document Type: Article

References (31)

1. Brown, S. E., C. R. Howard, A. J. Zuckerman, and M. W. Steward. 1984. Affinity of antibody responses in man to hepatitis B vaccine determined with synthetic peptides. Lancet ii:184-187.
2. Carman, W. F., M. R. Jacyna, S. Hadziyannis, P. Karayiannis, M. J. McGarvey, A. Markis, and H. C. Thomas. 1989. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet ii:588-591.
3. Carman, W. F., A. R. Zanetti, P. Karayiannis, J. Waters, G. Manzillo, E. Tanzi, A. J. Zuckerman, and H. C. Thomas. 1990. Vaccine-induced escape mutant of hepatitis B virus. Lancet 336:325-329.
4. Fernholz, D., P. R. Galle, M. Stemler, M. Brunetto, F. Bonino, and H. Will. 1993. Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier. Virology 194:137-148.
5. 145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus. Biochem. Biophys. Res. Commun. 184:1152-1157.
6. Gerken, G., D. Kremsdorf, F. Capel, M. A. Petit, C. Dauguet, M. P. Manns, K.-H. Meyer zum Büschenfelde, and C. Brechot. 1991. Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection. Virology 183:555-565.
7. Harrison, T. J., E. A. Hopes, C. J. Oon, A. R. Zanetti, and A. J. Zuckerman. 1991. Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. J. Hepatol. 13:S105-S107.
8. Hoofnagle, J. H., and D. F. Schafer. 1986. Serologic markers of hepatitis B virus infection. Sem. Liver Dis. 6:1-10.
9. Iizuka, H., K. Ohmura, A. Ishijima, K. Satoh, T. Tanaka, F. Tsuda, H. Okamoto, Y. Miyakawa, and M. Mayumi. 1992. Correlation between anti-HBc titers and HBV DNA in blood units without detectable HBsAg. Vox Sang. 63:107-111.
10. McLachlan, A., D. R. Milich, A. K. Raney, M. G. Riggs, J. L. Hughes, J. Sorge, and F. V. Chisari. 1987. Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences. J. Virol. 61:683-692.
11. McMahon, G., P. H. Ehrlich, Z. A. Moustafa, L. A. McCarthy, D. Dottavio, M. D. Tolpin, P. I. Nadler, and L. Östberg. 1992. Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients. Hepatology 15:757-766.
12. Moriyama, K., E. Nakajima, H. Hohjoh, R. Asayama, and K. Okochi. 1991. Immunoselected hepatitis B virus mutant. Lancet 337:125. (Letter.)
13. Neurath, A. R., S. B. H. Kent, N. Strick, P. Taylor, and C. E. Stevens. 1985. Hepatitis B virus containing pre-S gene-encoded domains. Nature (London) 315:154-156.
14. Ohnuma, H., A. Machida, H. Okamoto, F. Tsuda, M. Sakamoto, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1993. Allelic subtypic determinants of hepatitis B surface antigen (i and t) that are distinct from d/y or w/r. J. Virol. 67:927-932.
15. Okada, K., I. Kamiyama, M. Inomata, M. Imai, Y. Miyakawa, and M. Mayumi. 1976. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N. Engl. J. Med. 294:746-749.
16. Okamoto, H., M. Imai, M. Kametani, T. Nakamura, and M. Mayumi. 1987. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. Jpn. J. Exp. Med. 57:231-236.
17. Okamoto, H., M. Imai, S. Usuda, E. Tanaka, K. Tachibana, S. Mishiro, A. Machida, T. Nakamura, Y. Miyakawa, and M. Mayumi. 1985. Hemagglutination assay of polypeptide coded by the pre-S region of hepatitis B virus DNA with monoclonal antibody: correlation of pre-S polypeptide with the receptor for polymerized human serum albumin in serums containing hepatitis B antigens. J. Immunol. 134:1212-1216.
18. Okamoto, H., S. Usuda, M. Imai, K. Tachibana, E. Tanaka, T. Kumakura, M. Itabashi, E. Takai, F. Tsuda, T. Nakamura, Y. Miyakawa, and M. Mayumi. 1986. Antibody to the receptor for polymerized human serum albumin in the acute and persistent infection with hepatitis B virus, as well as in recipients of hepatitis B vaccine. Hepatology 6:354-359.
19. Okamoto, H., K. Yano, Y. Nozaki, A. Matsui, H. Miyazaki, K. Yamamoto, F. Tsuda, A. Machida, and S. Mishiro. 1992. Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine. Pediatr. Res. 32:264-268.
20. Okamoto, H., S. Yotsumoto, Y. Akahane, T. Yamanaka, Y. Miyazaki, Y. Sugai, F. Tsuda, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1990. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J. Virol. 64:1298-1303.
21. Paterlini, P., G. Gerken, E. Nakajima, S. Terre, A. D'Errico, W. Grigioni, B. Nalpas, D. Franco, J. Wands, M. Kew, E. Pisi, P. Tiollais, and C. Bréchot. 1990. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. N. Engl. J. Med. 323:80-85.
22. Radziwill, G., W. Tucker, and H. Schaller. 1990. Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity. J. Virol. 64:613-620.
23. Santantonio, T., M.-C. Jung, R. Schneider, D. Fernholz, M. Milella, L. Monno, G. Pastore, G. R. Pape, and H. Will. 1992. Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy. Virology 188:948-952.
24. Schaller, H., and M. Fischer. 1991. Transcriptional control of hepadnavirus gene expression. Curr. Top. Microbiol. Immunol. 168:21-39.
25. Schödel, F., A. M. Moriarty, D. L. Peterson, J. Zheng, J. L. Hughes, H. Will, D. J. Leturcq, J. S. McGee, and D. R. Milich. 1992. The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity. J. Virol. 66:106-114.
26. Steinhauer, D. A., and J. J. Holland. 1986. Direct method for quantitation of extreme polymerase error frequencies at selected single base sites in viral RNA. J. Virol. 57:219-228.
27. Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
28. Takahashi, K., S. Kishimoto, H. Ohnuma, A. Machida, E. Takai, F. Tsuda, H. Miyamoto, T. Tanaka, K. Matsushita, K. Oda, Y. Miyakawa, and M. Mayumi. 1986. Polypeptides coded for by the region pre-S and gene S of hepatitis B virus DNA with the receptor for polymerized human serum albumin: expression on hepatitis B particles produced in the HBeAg or anti-HBe phase of hepatitis B virus infection. J. Immunol. 136:3467-3472.
29. Thiers, V., E. Nakajima, D. Kremsdorf, D. Mack, H. Schellekens, F. Driss, A. Goudeau, J. Wands, J. Sninsky, P. Tiollais, and C. Brechot. 1988. Transmission of hepatitis B from hepatitis-B-seronegative subjects. Lancet ii:1273-1276.
30. Tiollais, P., C. Pourcel, and A. Dejean. 1985. The hepatitis B virus. Nature (London) 317:489-495.
31. Uy, A., V. Brass, W. H. Gerlich, H. G. Köchel, and R. Thomssen. 1986. Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core protein. Virology 155:89-96.