Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis

Science

Volumn 264, Issue 5159, 1994, Pages 713-716

  Dranoff, Glenn ^a,b,e   Crawford, Alexander D ^a   Sadelain, Michel ^a   Ream, Beverly ^a   Rashid, Asif ^b   Bronson, Roderick T ^c   Dickersin, G Richard ^b   Bachurski, Cindy J ^d   Mark, Eugene L ^b   Whitsett, Jeffrey A ^d   Mulligan, Richard C ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c TUFTS UNIVERSITY   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; GENE TARGETING; HEMATOPOIESIS; HOMEOSTASIS; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT;

EID: 0028263504     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.8171324     Document Type: Article

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42. S1 nuclease analysis was done as described in T. Yen, D. Gay, J. Pachter, D. Cleveland [Mol. Cell. Biol. 8, 1224 (1988)]. Probes used were as follows: SP-A from T. Korfhagen et al. [Am. J. Physiol. 263, L546 (1992)]; SP-B from M. D'AmoreBruno et al. [Am. J. Physiol. 262, L40 (1992)]; SP-C from S. Glasser et al. [J. Biol. Chem. 265, 21986 (1990)]; and actin from S. Alonso, A. Minty, Y. Bourlet, M. Buckingham [J. Mol. Evol. 23, 11 (1986)]. Open boxes represent exons; black boxes, introns; and lines, plasmid sequences. Antigen-adsorbed negative controls showed no background staining in panels (C) and (D).
43. S1 nuclease analysis was done as described in T. Yen, D. Gay, J. Pachter, D. Cleveland [Mol. Cell. Biol. 8, 1224 (1988)]. Probes used were as follows: SP-A from T. Korfhagen et al. [Am. J. Physiol. 263, L546 (1992)]; SP-B from M. D'AmoreBruno et al. [Am. J. Physiol. 262, L40 (1992)]; SP-C from S. Glasser et al. [J. Biol. Chem. 265, 21986 (1990)]; and actin from S. Alonso, A. Minty, Y. Bourlet, M. Buckingham [J. Mol. Evol. 23, 11 (1986)]. Open boxes represent exons; black boxes, introns; and lines, plasmid sequences. Antigen-adsorbed negative controls showed no background staining in panels (C) and (D).
44. S1 nuclease analysis was done as described in T. Yen, D. Gay, J. Pachter, D. Cleveland [Mol. Cell. Biol. 8, 1224 (1988)]. Probes used were as follows: SP-A from T. Korfhagen et al. [Am. J. Physiol. 263, L546 (1992)]; SP-B from M. D'AmoreBruno et al. [Am. J. Physiol. 262, L40 (1992)]; SP-C from S. Glasser et al. [J. Biol. Chem. 265, 21986 (1990)]; and actin from S. Alonso, A. Minty, Y. Bourlet, M. Buckingham [J. Mol. Evol. 23, 11 (1986)]. Open boxes represent exons; black boxes, introns; and lines, plasmid sequences. Antigen-adsorbed negative controls showed no background staining in panels (C) and (D).
45. S1 nuclease analysis was done as described in T. Yen, D. Gay, J. Pachter, D. Cleveland [Mol. Cell. Biol. 8, 1224 (1988)]. Probes used were as follows: SP-A from T. Korfhagen et al. [Am. J. Physiol. 263, L546 (1992)]; SP-B from M. D'AmoreBruno et al. [Am. J. Physiol. 262, L40 (1992)]; SP-C from S. Glasser et al. [J. Biol. Chem. 265, 21986 (1990)]; and actin from S. Alonso, A. Minty, Y. Bourlet, M. Buckingham [J. Mol. Evol. 23, 11 (1986)]. Open boxes represent exons; black boxes, introns; and lines, plasmid sequences. Antigen-adsorbed negative controls showed no background staining in panels (C) and (D).
46. S1 nuclease analysis was done as described in T. Yen, D. Gay, J. Pachter, D. Cleveland [Mol. Cell. Biol. 8, 1224 (1988)]. Probes used were as follows: SP-A from T. Korfhagen et al. [Am. J. Physiol. 263, L546 (1992)]; SP-B from M. D'AmoreBruno et al. [Am. J. Physiol. 262, L40 (1992)]; SP-C from S. Glasser et al. [J. Biol. Chem. 265, 21986 (1990)]; and actin from S. Alonso, A. Minty, Y. Bourlet, M. Buckingham [J. Mol. Evol. 23, 11 (1986)]. Open boxes represent exons; black boxes, introns; and lines, plasmid sequences. Antigen-adsorbed negative controls showed no background staining in panels (C) and (D).
47. 2-microglobulin-deficient mice, and W. Hull for surfactant protein analysis. We acknowledge the technical assistance of K. Edelman, K. Brose, L. Kieckens, C. Crawford, and J. Salter. We are grateful to V. Tybulewicz, M. Goodell, T. Jacks, S. Connor, and C. Gee for their help and advice. Supported by a USPHS Physician-Scientist Award (G.D.) and NIH grant HL37569 (R.C.M.).