Hypoxia-Selective Antitumor Agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: A New Class of Hypoxia-Selective Cytotoxins and Hypoxic Cell Radiosensitisers

Journal of Medicinal Chemistry

Volumn 37, Issue 3, 1994, Pages 381-391

  Hay, Michael P ^a,b   Wilson, William R ^a,c   Moselen, John W ^a,c   Palmer, Brian D ^a,b   Denny, William A ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Cancer Research Laboratory   (New Zealand)

^c Department of Pathology ^*  (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; CYTOTOXIC AGENT; MISONIDAZOLE; N [2 (2 METHYL 5 NITRO 1H IMIDAZOLYL)ETHYL] 4 (2 NITRO 1H IMIDAZOLYL)BUTANAMIDE; SN 24699; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER RESEARCH; CELL HYPOXIA; CHINESE HAMSTER; CONTROLLED STUDY; DNA CROSS LINKING; DRUG RESEARCH; DRUG SELECTIVITY; NONHUMAN; RADIOSENSITIVITY; STRUCTURE ACTIVITY RELATION;

AEROBIOSIS; ANIMAL; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL HYPOXIA; CELL LINE; CHEMISTRY, PHYSICAL; CRICETULUS; DNA REPAIR; HAMSTERS; IMIDAZOLES; MICE; MICE, INBRED C3H; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; RADIATION-SENSITIZING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0028261377     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00029a010     Document Type: Article

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