Preventing fungal infection in neutropenic patients with acute leukemia: Fluconazole compared with oral amphotericin B

Annals of Internal Medicine

Volumn 120, Issue 11, 1994, Pages 913-918

  Menichetti, Francesco ⁱ   Del Favero, Albano ⁱ   Martino, Piero ^a   Bucaneve, Giampaolo ⁱ   Micozzi, Alessandra ^a   D'Antonio, Domenico ^b   Ricci, Paolo ^c   Carotenuto, Mario ^d   Liso, Vincenzo ^e   Nosari, Anna Maria ^f   Barbui, Tiziano ^g   Fasola, Giampiero ^h   Mandelli, Franco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^e UNIVERSITY OF BARI   (Italy)

^f OSPEDALE NIGUARDA CA GRANDA   (Italy)

^g OSPEDALI RIUNITI   (Italy)

^h UNIVERSITY OF UDINE   (Italy)

ⁱ NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE;

ACUTE LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIOLOGY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MYCOSIS; NEUTROPENIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SYSTEMIC MYCOSIS; THRUSH;

EID: 0028243197     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-120-11-199406010-00003     Document Type: Article

References (21)

1. DeGregorio MW, Lee MW, Linker CA, Jacobs RA, Ries CA. Fungal infections in patients with acute leukemia. Am J Med. 1982;73: 543-8.
2. Clift RA. Candidiasis in the transplant patient. Am J Med. 1984; 77(Suppl. 4D):34-8.
3. Pizzo PA, Robichaud KJ, Gill FA, Witebsky FG. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med. 1982;72:101-11.
4. EORTC International Antimicrobial Therapy Cooperative Group. Empiric antifungal therapy in febrile granulocytopenic patients. Am J Med. 1989;86:668-72.
5. Meunier F. Prevention of mycoses in immunocompromised patients. Rev Infect Dis. 1987;9:408-16.
6. Ezdinli EZ, O'Sullivan DD, Wasser LP, Kim U, Stutzman L. Oral amphotericin for candidiasis in patients with hematologic neoplasms. An autopsy study. JAMA. 1979;242:258-60.
7. Goodman JL, Winston DJ, Greenfield RA, Chandrasekar PH, Fox B, Kaizer H, et al. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med. 1992;326:845-51.
8. Winston DJ, Chandrasekar PH, Lazarus HM, Goodman JL, Silber JL, Horowitz H, et al. Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial. Ann Intern Med. 1993; 118:495-503.
9. GIMEMA. GIMEMA ALL 0183: a multicentric study on adult acute lymphoblastic leukemia. The 1990 update [Abstract 1248]. Proceedings of the International Society of Hematology XXIII Congress and of the American Society of Hematology XXXII Annual Meeting, Boston, 28 November-4 December 1990. Blood. 1990; 76(Suppl. 1):314.
10. EORTC/GIMEMA. Allogenic versus autologous BMT versus intensive consolidation in acute myelogenous leukemia in first remission. An EORTC/GIMEMA phase III trial (LAM 8 A) [Abstract 1349]. Proceedings of the International Society of Hematology XXIII Congress and of the American Society of Hematology XXXII Annual Meeting, Boston, 28 November-4 December 1990. Blood. 1990; 76(Suppl. 1):340.
11. The Gimema Infection Program. Prevention of bacterial infection in neutropenic patients with hematologic malignancies. A randomized, multicenter trial comparing norfloxacin with ciprofloxacin. Ann Intern Med. 1991;115:7-12.
12. Rozenberg-Arska M, Dekker AW, Branger J, Verhoef J. A randomized study to compare oral fluconazole to amphotericin B in the prevention of fungal infections in patients with acute leukemia. J Antimicrob Chemother. 1991;27:369-76.
13. Meunier F, Aoun M, Janssens C, Dekoster C, Paesmans M. Chemoprophylaxis of fungal infections in granulocytopenic patients using fluconazole vs oral ampholericin B. Drug Invest. 1991;3:258-65.
14. Schimpff S, Young VM, Greene WH, Vermeulen GD, Moody MR, Wiernik PR. Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Ann Intern Med. 1972;77:707-14.
15. Milliken S, Helenglass G, Powles R. Fluconazole pharmacokinetics following oral dosage in leukemic patients receiving autologous bone marrow transplantation. Bone Marrow Transplant. 1988;3:324-5.
16. Wingard JR, Merz WG, Rinaldi MG, Johnson TR, Karp JE, Saral R. Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N Engl J Med. 1991;325:1274-7.
17. Schuler U, Ehninger G, Brammer K. Oral fluconazole vs. oral polyenes as antimycotic prophylaxis in neutropenia: an European multicenter study [Abstract 87). 18th Annual Meeting of the European Group for Bone Marrow Transplantation. Stockholm, Sweden, 31 May-3 June 1992:86.
18. Dick JD, Merz WG, Saral R. Incidence of polyene-resistant yeasts recovered from clinical specimens. Antimicrob Agents Chemother. 1980;18:158-63.
19. Merz WG. Candida lusitaniae: frequency of recovery, colonization, infection, and amphotericin B resistance. J Clin Microbiol. 1984;20: 1194-5.
20. Persons DA, Laughlin M, Tanner D, Perfect J, Gockerman JP, Hathorn JW. Fluconazole and Candida krusei fungemia [Letter]. N Engl J Med. 1991;325:1315.
21. Schuler U, Ehninger G. Prophylactic fluconazole and Candida krusei infection (Letter). N Engl J Med. 1992;326:892.