Nosocomial Bloodstream Infection in Critically III Patients: Excess Length of Stay, Extra Costs, and Attributable Mortality

JAMA: The Journal of the American Medical Association

Volumn 271, Issue 20, 1994, Pages 1598-1601

  Pittet, Didier ^a   Tarara, Debra ^a   Wenzel, Richard P ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BACTEREMIA; BLOOD CULTURE; CASE CONTROL STUDY; CLINICAL FEATURE; CONTROLLED STUDY; CRITICAL ILLNESS; DEMOGRAPHY; FEMALE; HEALTH CARE COST; HOSPITAL INFECTION; HUMAN; INFECTION COMPLICATION; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; SEPSIS; SURVIVAL;

CASE-CONTROL STUDIES; CRITICAL ILLNESS; CROSS INFECTION; HOSPITAL BED CAPACITY, 500 AND OVER; HOSPITAL COSTS; HOSPITAL MORTALITY; HOSPITALS, UNIVERSITY; HUMAN; INTENSIVE CARE UNITS; IOWA; LENGTH OF STAY; SEPTICEMIA; SURVIVAL RATE;

EID: 0028241340     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1994.03510440058033     Document Type: Article

References (33)

1. Daschner FD, Frey P, Wolff G, Baumann PC, Suter P. Nosocomial infections in intensive care wards: A multicenter prospective study. Intensive Care Med. 1982;8:5-9.
2. Donowitz LG, Wenzel RP, Hoyt JW. High risk of hospital-acquired infection in the ICU patient. Crit Care Med. 1982;10:355-357.
3. Duggan JM, Oldfield GS, Ghosh HK. Septicaemia as a hospital hazard. J Hosp Infect. 1985;6:406-412.
4. Pittet D. Nosocomial bloodstream infections. In: Wenzel RP, ed. Prevention and Control of Nosocomial Infections. 2nd ed. Baltimore, Md: Williams & Wilkins; 1993:512-555.
5. Craven DE, Kunehes LM, Lichtenberg DA, et al. Nosocomial infection and fatality in medical surgical intensive care unit patients. Arch Intern Med. 1988;148:1161-1168.
6. Pittet D, Herwaldt LA, Massanari RM. The intensive care unit. In: Brachman PS, Bennett JV, eds. Hospital Infections. 3rd ed. Boston, Mass: Little Brown & Co Inc; 1992:405-439.
7. Kreger BE, Craven DE, Carling PC, McCabe WR. Gram-negative bacteremia, III: Reassessment of etiology, epidemiology and ecology in 612 patients. Am J Med. 1980;68:332-343.
8. Weinstein MP, Murphy JR, Reller LB, Lichtenstein KA. The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults, II: Clinical observations, with special reference to factors influencing prognosis. Rev Infect Dis. 1983;5: 54-70.
9. Gatell JM, Trilla A, Latorre X, et al. Nosocomial bacteremia in a large Spanish teaching hospital: Analysis of factors influencing prognosis. Rev Infect Dis. 1988;10:203-210.
10. Wenzel RP. The mortality of hospital-acquired bloodstream infections: Need for a new vital statistic? Int J Epidemiol. 1988;17:225-227.
11. Martin MA, Pfaller MA, Wenzel RP. Coagulase-negative staphylococcal bacteremia: Mortality and hospital stay. Ann Intern Med. 1989;110:9-16.
12. Landry SL, Kaiser DL, Wenzel RP. Hospital stay and mortality attributed to nosocomial enterococcal bacteremia: A controlled study. Am J Infect Control. 1989;17:323-329.
13. Wey SB, Motomi M, Pfaller MA, Woolson RF, Wenzel RP. Hospital-acquired candidemia: The attributable mortality and excess length of stay. Arch Intern Med. 1988;148:2642-2645.
14. Broderick A, Mori M, Nettleman MD, Streed SA, Wenzel RP. Nosocomial infections: Validation of surveillance and computer modeling to identify patients at risk. Am J Epidemiol. 1990;131:734-742.
15. Garner JS, Jarvis WR, Emori TG. CDC definition for nosocomial infections. Am J Infect Control. 1988;16:128-140.
16. International Classification of Diseases, 9th Revision, Clinical Modification: ICD-9-CM. 3rd ed. Washington, DC: US Dept of Health and Human Services; 1989. US Public Health Service publication PHS 89-1260.
17. Haley RW. Measuring the costs of nosocomial infections: Methods for estimating economic burden on the hospital. Am J Med. 1991;91:32S-38S.
18. Conover WJ. Practical Nonparametric Statistics. 2nd ed. New York, NY: John Wiley & Sons Inc; 1980:363-364.
19. Bishop YMM, Feinberg SE, Holland PW. Discrete Multivariate Analyses: Theory and Practice. Cambridge: The Massachusetts Institute of Technology Press; 1975:492-497.
20. Miettinen OS. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976;103: 226-235.
21. McGowan JE Jr, Barnes MW, Finland M. Bacteremia at Boston City Hospital: Occurrence and mortality during 12 selected years (1935-1972) with special reference to hospital-acquired cases. J Infect Dis. 1975;132:316-335.
22. Bodey GP, Nies BA, Freireich EJ. Multiple organism septicemia in acute leukemia. Arch Intern Med. 1965;116:266-272.
23. McGowan JE Jr. Changing etiology of nosocomial bacteremia and fungemia and other hospitalacquired infections. Rev Infect Dis. 1985;7(suppl 3):S357-S370.
24. Bryan CS, Hornung CA, Reynolds KL, Brenner ER. Endemic bacteremia in Columbia, South Carolina. Am J Epidemiol. 1986;123:113-127.
25. Centers for Disease Control. Increase in national hospital discharge survey rates for septicemia—United States. MMWR Morb Mortal Wkly Rep. 1990;39:31-34.
26. Banerjee SN, Emori TG, Culver DH, et al. Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989: National Nosocomial Infections Surveillance System. Am J Med. 1991;91(suppl 3B):86S-89S.
27. Rose R, Hunting KJ, Townsend TR, Wenzel RP. Morbidity/mortality and economics of hospitalacquired blood stream infections: A controlled study. South Med J. 1977;70:1267-1269.
28. Spengler RF, Greenough WB III. Hospital costs and mortality attributed to nosocomial bacteremias. JAMA. 1978;240:2455-2458.
29. Ponce de Leon S, Wenzel RP. Hospital-acquired bloodstream infections with Staphylococcus epidermidis. Am J Med. 1984;77:639-644.
30. Dominguez-de Villota E, Algora-Weber A, Millan I, Rubio JJ, Galdes P, Mosquera JM. Early evaluation of coagulase-negative staphylococcus in blood samples of intensive care unit patients: A clinically uncertain judgement. Intensive Care Med. 1987;13:390-394.
31. McCabe WR, Jackson GG. Gram-negative bacteremia, II: Clinical, laboratory, and therapeutic observations. Arch Intern Med. 1962;110:856-864.
32. Bryan CS, Reynolds KL, Brenner ER. Analysis of 1186 episodes of gram-negative bacteremia in non-university hospitals: The effects of antimicrobial therapy. Rev Infect Dis. 1983;5:629-638.
33. SchlesselmanJJ. Case-Control Studies: Design, Conduct, Analysis. New York, NY: Oxford University Press; 1982.