Ws79089a, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

The Journal of Antibiotics

Volumn 47, Issue 6, 1994, Pages 619-630

  Tsurumi, Yasuhisa ^a   Ohhata, Nobutaka ^a   Iwamoto, Toshiro ^a   Shigematsu, Nobuharu ^a   Sakamoto, Kazutoshi ^a   Nishikawa, Motoaki ^a   Kiyoto, Sumio ^a   Okuhara, Masakuni ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5,6,8,13 TETRAHYDRO 1,6,9,14 TETRAHYDROXY 3 (2 HYDROXYPROPYL) 7 METHOXY 8,13 DIOXOBENZO[A]NAPHTHACENE 2 CARBOXYLIC ACID; ANTIBIOTIC AGENT; ENDOTHELIN CONVERTING ENZYME; ENZYME INHIBITOR; UNCLASSIFIED DRUG; WS 79089A; WS 79089C;

ANIMAL TISSUE; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; FUNGUS CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT;

ACTINOMYCETALES; AMINO ACID SEQUENCE; ANIMAL; ANTIBIOTICS; ASPARTIC ENDOPEPTIDASES; BACTERIA; BONE MARROW; BONE MARROW CELLS; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FERMENTATION; FUNGI; GLYCOPEPTIDES; HUMAN; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; MUTAGENICITY TESTS; RATS; SOIL MICROBIOLOGY; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; TETRACYCLINES; TIME FACTORS;

EID: 0028240445     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.47.619     Document Type: Article

References (25)

1. Yanagisawa, M.; H. Kurihara, S. Kimura, Y. Tomobe, Y. Mitsui, T. Yazaki, K. Goto & T. Masaki: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411~415, 1988.
2. Miyauchi, T.; M. Yanagisawa, T. Tomizawa, Y. Sugisita, M. Fujino, R. Ajisaka, K. Goto & T. Masaki: Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction. Lancet 2: 53 ~ 54, 1989.
3. Sawamura, T.; S. Kimura, S. Shinmi, O. Sugita, M. Yanagisawa & T. Masaki: Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1. Biochem. Biophys. Res. Commun. 162: 1287-1294, 1989.
4. Suzuki, N.; H. Matsumoto, C. Kitada, S. Kimura & M. Fujino: Production of endothelin-1 and big-endothelin-1 by tumor cells with epithelial-like morphology. J. Biochem. 106: 736 ~ 741, 1989.
5. Ikegawa, R.; Y. Matsumura, Y. Tsukahara, M. Takaoka & S. Morimoto: Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme. Biochem. Biophys. Res. Commun. 171: 669 ~ 675, 1990.
6. Sawamura, T.; Y. Kasuya, Y. Matsushita, N. Suzuki, O. Shinmi, N. Kishi, Y. Sugita, M. Yanagisawa, K. Goto & T. Masaki: Phosphoramidon inhibits the endothelin-1 in cultured endothelial cells. Biochem. Biophys. Res. Commun. 174: 779~784, 1991.
7. Fukuroda, T.; K. Noguchi, S. Tsuchida, M. Nishikibe, F. Ikemoto, K. Okada & M. Yano: Inhibition of biological action of big endothelin-1 by phosphoramidon. Biochem. Biophys. Res. Commun. 172: 390 ~ 395, 1990.
8. Matsumura, Y.; K. Hisaki, M. Takaoka & S. Morimoto: Phosphoramidon, a metalloproteinase inhibitor, suppress the hypertensive effect of big endothelin-1. Eur. J. Pharmacol. 185: 103 ~ 106, 1990.
9. Matsumura, Y.; K. Hisaki, M. Takaoka & S. Morimoto. Phosphoramidon, a metalloprotease inhibitor, suppresses the hypertensive effect of big endothelin-1. Eur. J. Pharmacol. 185: 103 ~ 106, 1990.
10. McMahon, E. G.; M. A. Palomo, W. M. Moore, J. F. MaDonald & M. K. Stern: Phosphoramidon blocks the pressor activity of porcine big endothelin-l-(l-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vivo. Proc. Natl. Acad. Sci. U.S.A. 88: 703 ~ 707, 1991.
11. Shirling, E. B. & D. Gottlieb: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313~340, 1966.
12. Waksman, S. A.: The Actinomycetes Vol. 2: Classification Identification and Description of Genera and Species: The Williams and Wilkins Co., Baltimore, 1961.
13. Kornerup, A. & J. H. Wanscher: Methuen Handbook of Colour. Methuen, London, 1978.
14. Becker, B.; M. P. Lechevalier, R. E. Gordon & H. A. Lechevalier: Rapid differentiation between Nocardia and Streptomyces by paper chromatography of whole-cell hydrolysates: Appi. Microbiol. 12: 421~423, 1964.
15. Lechevalier, M. P. & H. Lechevalier: Chemical composition as a criterion in the classification of aerobic actinomycetes. Int. J. Syst. Bacteriol. 20: 435 ~ 443, 1970.
16. Lechevalier, M. P.; C. De Bievre & H. A. Lechevalier: Chemotaxonomy of aerobic actinomycetes: phospholipid composition. Biochem. Syst. Ecol. 5: 249 - 260, 1977.
17. Buchanan, R. E. & N. E. Gibbons: Bergey's Manual of Determinative Bacteriology, 8th edition. The Williams and Wilkins Co., Baltimore, 1974.
18. Williams, S. T.: Bergey's Manual of Systematic Bacteriology. Vol. 4. Williams and Wilkins, Baltimore, 1989.
19. Skerman, V. B. D.; V. McGowan & P. H. A. Sneath: Approved lists of bacterial names (Amended edition): American Society for Microbiology, Washington, D.C., 1989.
20. Hayakawa, M. & H. Nonomura: Humic acid-vitamin agar, a new medium for the selective isolation of soil actinomycetes. J. Ferment. Technol. 65: 501 ~ 509, 1987.
21. Okada, K.; Y. Miyazaki, J. Takada, K. Matsuyama, T. Yamaki & M. Yano: Conversion of big endothelin-1 by membrane-bound metalloproendopeptidase in cultured bovine endothelial cells. Biochem. Biophys. Res. Commun. 171: 1192~1198, 1990.
22. Ohnaka, K.; R. Takayanagi, T. Yamauchi, H. Okazaki, M. Ohashi, F. Umeda & H. Nawata: Identification and characterization of endothelin converting activity in cultured bovine endothelial cells. Biochem. Biophys. Res. Commun. 168: 1128~1136, 1990.
23. Ohnaka, K.; R. Takayanagi, M. Nishikawa, M. Haji & H. Nawata: Purification and characterization of a phosphoramidon-sensitive endothelin converting enzyme in porcine aortic endothelium. J. Biol. Chem. 268: 26759~26766, 1993.
24. Ames, B. N.; J. McCann & E. Yamasaki: Method for detecting carcinogenic and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Res. 31: 347 ~ 364, 1975.
25. Oki, T.; M. Konishi, K. Tomatsu, K. Tomita, K. Saitoh, M. Tsunakawa, M. Nishio, T. Miyaki & H. Kawaguchi: Pradimicin, a novel class of potent antifungal antibiotics. J. Antibiotics 41: 1701 ~1704, 1988.