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Bioorganic and Medicinal Chemistry Letters

Volumn 4, Issue 12, 1994, Pages 1467-1472

Structure-activity relationship of novel distamycin a derivatives:synthesis and antitumor activity

(6) D'Allessio, Roberto a Geroni, Cristina a Biasoli, Giovanni a Pesenti, Enrico a Grandi, Maria a Mongelli, Nicola a

a PFIZER INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISTAMYCIN A; DISTAMYCIN A DERIVATIVE; DOXORUBICIN; TALLIMUSTINE;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SYNTHESIS; LEUKEMIA; LEUKEMIA L 1210; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

EID: 0028237423 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(01)80515-1 Document Type: Article

Times cited : (42)

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- 6).7b: α 2.64(2H, m), 2.89(2H, m), 3.50(2H, m), 3.55(1H, dd), 3.81(3H,s), 3.84(6H, s), 6.9-7.3(6H, m), 8.22(1H, bt), 8.4-9.4(4H, br), 9.9(3H, br) ppm;7c: α 2.65(2H, t), 3.50(2H, m), 3.80(3H, s), 3.83(3H, s), 3.84(3H, s), 5.98(1H, d), 6.40(1H, d), 6.9-7.3(6H, m), 8.20(1H, t), 8.75(2H, bs), 9.04(2H, bs), 9.89(1H, s), 9.95(1H, s), 10.32(1H, s) ppm;7d: α 2.62(2H, t), 3.45(2H, m), 3.81(3H, s), 3.85(6H, s), 6.20(1H, d), 6.70(1H, d), 6.9-7.3(6H, m), 8.18(1H, t), 8.60(2H, bs), 8.96(2H, bs), 9.88(1H, s), 9.93(1H, s), 10.29(1H, s) ppm;8a α 2.63(2H, t), 3.20-3.90(10H, m), 3.80-3.85(12H, s), 6.83(2H, d, J=8.85), 6.92-7.32(8H, m), 7.87(2H, d, J=8.85), 8.20(1H, bt), 8.95(4H, br), 9.90(3H, br), 10.001H, br, ppm;8b: α 2.63(2H, m), 2.89(2H, m), 3.50(2H, m), 3.57(1H, dd), [[Truncated]]

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