Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788

Proceedings of the National Academy of Sciences of the United States of America

Volumn 91, Issue 11, 1994, Pages 4892-4896

  Ishikawa, Kiyofumi ^a   Ihara, Masaki ^a   Noguchi, Kazuhito ^a   Mase, Toshiaki ^a   Mino, Nobuyuki ^a   Saeki, Toshihiko ^a   Fukuroda, Takahiro ^a   Fukami, Takehiro ^a   Ozaki, Satoshi ^a   Nagase, Toshio ^a   Nishikibe, Masaru ^a   Yano, Mitsuo ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

receptor subtype

Indexed keywords

CALCIUM ION; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN 3; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR AGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; IODINE 125; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N ACETYLENDOTHELIN 1 [6-21][11,15 ALANINE]; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRONCHOSPASM; CALCIUM CELL LEVEL; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DRUG POTENCY; DRUG SELECTIVITY; GUINEA PIG; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROBLASTOMA CELL; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SWINE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

AMINO ACID SEQUENCE; ANIMAL; CELL LINE; GUINEA PIGS; HUMAN; MALE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PIPERIDINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; TUMOR CELLS, CULTURED;

ANIMALIA; CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0028237258     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.91.11.4892     Document Type: Article

References (34)