Transcriptional elongation by RNA polymerase II is stimulated by transactivators

Cell

Volumn 77, Issue 5, 1994, Pages 749-759

  Yankulov, Krassimir ^a   Blau, Justin ^a   Purton, Tracey ^a   Roberts, Sadia ^a   Bentley, David L ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; RNA POLYMERASE II; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; ENHANCER REGION; GENE EXPRESSION REGULATION; HUMAN IMMUNODEFICIENCY VIRUS; MOUSE; NONHUMAN; ONCOGENE C MYC; OOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TATA BOX; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; XENOPUS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0028236808     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90058-2     Document Type: Article

References (61)

1. Role of the mammalian transcription factors IIF IIS and IIX during elongation by RNA polymerase II
2. A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells
3. Sequence requirements for premature termination of transcription in the human c-myc gene
4. Accurate TATA box-dependent polymerase III transcription from promoters of the c-myc gene in injected Xenopus oocytes
5. Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat
6. Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II
7. Purification of protein kinases that phosphorylate the repetitive carboxyl-terminal domain of eukaryotic RNA polymerase II
8. Does HIV-1 Tat induce a change in viral initiation rights?
9. Regulation of RNA polymerase II transcription
10. Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression
11. The specificity of the human immunodeficiency virus type 2 transactivator is different from that of human immunodeficiency virus type 1
12. Differential regulation of three members of the ATF/CREB family of DNA-binding proteins
13. The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex
14. Promoter melting and TFIID complexes on Drosophila genes in vivo
15. Negative effect of the transcriptional activator GAL4
16. Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit
17. Transcriptional anti-termination
18. Premature termination of tubulin gene transcription in Xenopus oocytes is due to promoter-dependent disruption of elongation
19. Conserved arrangement of nested genes at the Drosophila Gart locus
20. The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels
21. Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
22. HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors
23. The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region
24. HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation
25. Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation
26. DNA sequence requirements for generating paused polymerase at the start of hsp70
27. Transcription activation by the adenovirus E1a protein
28. GAL4 derivatives function alone and synergistically with mammalian activators in vitro
29. Protein traffic on the heat shock promoter parking stalling and trucking along
30. The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes only one of which is regulated by Tat
31. HIV-1 Tat protein promotes formation of more-processive elongation complexes
32. Control of formation of two distinct classes of RNA polymerase II elongation complexes
33. Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene
34. Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNA I
35. Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration 56-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB) and promoter mutagenesis
36. Premature termination of transcription can be induced on an injected α-tubulin gene in Xenopus oocytes
37. A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT) gene transfer into cells obtained from humans deficient in HPRT
38. Mapping of RNA-polymerase on mammalian genes in cells and nuclei
39. Three distinct elements within the murine c-myc promoter are required for transcription
40. Intragenic pausing and anti-sense transcription within the murine c-myc locus
41. The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa
42. Sequence requirements for transcriptional arrest in exon 1 of the murine adenosine deaminase gene
43. Distinct modes of transcription read through or terminate at the c-myc attenuator
44. A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcription
45. The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D melanogaster is transcriptionally engaged
46. Postinitiation transcriptional control in Drosophila melanogaster
47. GAL4-VP16 is an unusually potent transcriptional activator
48. Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription
49. Characterization of the inducer of short transcripts a human immunodeficiency virus type 1 transcriptional element that activates the synthesis of short RNAs
50. The HIV-1 Tat protein activates transcription from an upstream DNA-binding site implications for Tat function
51. Transcription elongation in the human c-myc gene is governed by overall transcription initiation levels in Xenopus oocytes
52. The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles
53. 56-Dichloro-1-β-d-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide
54. Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo
55. Definition of subclasses of nucleoplasmic RNA
56. The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence
57. The mammalian TFIID protein is present in two functionally distinct complexes
58. In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions
59. Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA
60. Premature termination of transcription from the P1 promoter of the mouse c-myc gene
61. Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter