Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach

International Journal of Pharmaceutics

Volumn 108, Issue 2, 1994, Pages 85-93

  Hauss, David J ^a   Mehta, Surendra C ^a   Radebaugh, Galen W ^a  

^a PFIZER INC   (United States)

Author keywords

ACAT inhibitor; Chylomicron; Drug delivery; Drug distribution; Drug targeting; Emulsion; Lymph; Lymphatic transport

Indexed keywords

2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; ANTILIPEMIC AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG TARGETING; DRUG TISSUE LEVEL; DRUG TRANSPORT; GASTROINTESTINAL TRACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT;

EID: 0028234686     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(94)90318-2     Document Type: Article

References (11)

1. Comparison of CI-976, an ACAT inhibitor and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions
2. Transport of lipophilic molecules by the intestinal lymphatic system
3. Targeting of drugs to the lymph
4. Absorption transport and metabolism of vitamin E
5. The determination of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl dodecanamide, a lipid regulator, in rat plasma and mesenteric lymph by reversed-phase high performance liquid chromatography
6. Participation of the lymphatic system in the absorption of pharmaca from the gut
7. Hepatic uptake of chylomicrons and triglyceride emulsions in rats fed diets of differing fat content
8. Factors affecting the lymphatic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: Comparison to DDT and hexachlorobenzene
9. Intestinal lymphatic transport of lipophilic molecules
10. Targeting of orally administered lipophilic drugs to the lymphatic system