Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

Biochemical Pharmacology

Volumn 47, Issue 9, 1994, Pages 1643-1653

  Christopher Gorski, J ^a,b   Hall, Stephen D ^b   Jones, David R ^b   VandenBranden, Mark ^c  

^a PURDUE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

CYP3A subfamily; cytochrome P450; human liver microsomes; hydroxylation; midazolam; regioselective

Indexed keywords

4 HYDROXYMIDAZOLAM; ALPHA HYDROXYMIDAZOLAM; CYTOCHROME B5; CYTOCHROME P450 ISOENZYME; DILAUROYLPHOSPHATIDYLCHOLINE; DRUG METABOLITE; ERYTHROMYCIN; FLUNITRAZEPAM; MIDAZOLAM; N DEMETHYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RECONSTITUTION; FETUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME METABOLISM; PRIORITY JOURNAL;

BIOTRANSFORMATION; COMPARATIVE STUDY; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; FETUS; HUMAN; ISOENZYMES; KINETICS; MICROSOMES, LIVER; MIDAZOLAM; MIXED FUNCTION OXYGENASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028234586     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90543-6     Document Type: Article

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