Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty

Molecular and Cellular Neurosciences

Volumn 5, Issue 3, 1994, Pages 246-262

  Ma, Ying Jun ^a,b   Hill, Diane F ^a   Junier, Marie Pierre ^a,d   Costa, Maria E ^a   Felder, Stephen E ^c,e   Ojeda, Sergio R ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Rhone Poulene Rorer Central Research ^*  (United States)

^d HENRI MONDOR HOSPITAL   (France)

^e Selectide Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0028232262     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1994.1029     Document Type: Article

References (85)

1. Carpenter, G., and S. Cohen (1990). Epidermal growth factor, J. Biol. Chem. 265: 7709-7712.
2. Derynck, R. (1988). Transforming growth factor a. Cell 54: 593-595.
3. Massague, J. (1990). Transforming growth factor-α, A model for membrane-anchored growth factors. J. Biol. Chem. 265: 21393-21396.
4. Shoyab, M., G. D. Plowman, V. L. McDonald, J. G. Bradley, and G. J. Todaro (1989). Structure and function of human amphiregulin: A member of the epidermal growth factor family. Science 243: 1074-1076.
5. Higashiyama, S., J. A. Abraham, J. Miller, J. C. Fiddes, and M. Klagsbrun (1991). A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251: 936-939.
6. erbB2. Science 256: 1205-1210.
7. Kimura, H., W. H. Fischer, and D. Schubert (1990). Structure, expression and function of a schwannoma-derived growth factor. Nature 348: 257-260.
8. Marchionni, M. A., A. D. J. Goodearl, M. S. Chen, O. Bermingham-McDonogh, C. Kirk, M. Hendricks, F. Danehy, D. Misumi, J. Sud-halter, K. Kobayashi, D. Wroblewski, C. Lynch, M. Baldassare, I. Hiles, J. B. Davis, J. J. Hsuan, N. F. Totty, M. Otsu, R. N. McBurney, M. D. Waterfield, P. Stroobant, and D. Gwynne (1993). Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362: 312-318.
9. Rutledge, B. J., K. Zhang, E. Bier, Y. N. Jan, and N. Perrimon (1992). The Drosophilia spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Deo. 6: 1503-1517.
10. Fallon, J. H., K. B. Seroogy, S. E. Loughlin, R. S. Morrison, R. A. Bradshaw, D. J. Knauer, and D. D. Cunningham (1984). Epidermal growth factor immunoreactive material in the central nervous system: Location and development. Science 224: 1107-1109.
11. Schaudies, R. P., E. L. Christian, and C. R. Savage, Jr. (1989). Epidermal growth factor immunoreactive material in the rat brain. J. Biol. Chem. 264: 10447-10450.
12. Fallon, J. H., C. M. Annis, L. E. Gentry, and D. R. Twardzik (1990). Localization of cells containing transforming growth factor-α precursor immunoreactivity in the basal ganglia of the adult rat brain. Growth Factors 2: 241-250.
13. Kudlow, J. E., A. W. C. Leung, M. S. Kobrin, A. J. Paterson, and S. L. Asa (1989). Transforming growth factor-α in the mammalian brain. J. Biol. Chem. 264: 3880-3883.
14. Loy, R., D. Heyer, and P. DiStefano (1988). Sensitivity of substantia nigra neurons to epidermal growth factor. Soc. Neurosci. Abstr. 14: 302.
15. Leutz, A., and M. Schachner (1981), Epidermal growth factor stimulates DNA synthesis of astrocytes for primary cerebellar cultures. Cefi Tissue Res. 220: 393-404.
16. Simpson, D. L., R. Morrison, J. deVellis, and H. R. Herschman (1982). Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system. J. Neurosci. Res. 8: 453-462.
17. Morrison, R. S., H. I. Kornblum, F. M. Leslie, and R. A. Bradshaw (1987). Trophic stimulation of cultured neurons from neonatal rat brain by epidermal growth factor. Science 238: 72-74.
18. Anchan, R. M., T. A. Reh, J. Angello, A. Balliet, and M. Walker (1991). EGF and TGF-α stimulate retinal neuroepithelial cell proliferation in oitro. Neuron 6: 923-936.
19. Morrison, R. S. (1989). Epidermal growth factor and transforming growth factor alpha stimulate survival of neurons from multiple regions of the CNS. Soc. Neurosci. Abstr. 15: 1361.
20. Alexi, T., and F. Hefti (1992). TGF α selectively increases dopaminergic cell survival in ventral mesencephalic cultures. Soc. Neurosci. Abstr. 18: 1292.
21. Chalazonitis, A., J. A. Kessler, D. R. Twardzik, and R. S. Morrison (1992). Transforming growth factor α, but not epidermal growth factor, promotes the survival of sensory neurons in vitro. J. Neurosci. 12: 583-594.
22. Kaser, M. R., J. Lakshmanan, and D. A. Fisher (1992). Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain. Mol. Brain Res. 16: 316-322.
23. Lazar, L. M., and M. Blum (1992). Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-a mRNA in mouse brain by a quantitative nuclease protection assay. J. Neurosci. 12: 1686-1697.
24. Ojeda, S. R., H. F. Urbanski, M. E. Costa, D. F. Hill, and M. Moholt-Siebert (1990). Involvement of transforming growth factor a in the release of luteinizing-hormone releasing hormone from the developing female hypothalamus. Proc. Natl. Acad. Sci. USA 87: 9698-9702.
25. Wang, S., K. T. Shiverick, S. Ogilvie, W. A. Dunn, and M. K. Raizada (1989). Characterization of epidermal growth factor receptors in astrocytic glial and neuronal cells in primary culture. Endocrinology 124: 240-247.
26. Quirion, R., D. Araujo, N. P. V. Nair, and J. Chabot (1988). Visualization of growth factor receptor sites in rat forebrain. Synapse 2:212-218.
27. Gomez-Pinilla, F., D. J. Knauer, and M. Nieto-Sampedro (1988). Epidermal growth factor receptor immunoreactivity in rat brain. Brain Res. 438: 385-390.
28. Werner, M. H., L. B. Nanney, C. M. Stoscheck, and L. E. King (1988). Localization of immunoreactive epidermal growth factor receptors in human nervous system. J. Histochem. Cytochem. 36: 81-86.
29. Nieto-Sampedro, M., F. Gomez-Pinilla, D. J. Knauer, and J. T. Broderick (1988). Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury. Neurosci. Lett. 91: 276-282.
30. McCann, S. M. (1982). Physiology and pharmacology of LHRH and somatostatin. Annu. Rev. Pharmacol. Toxicol. 22: 491-515.
31. Ojeda, S. R., and H. F. Urbanski (1994). Puberty in the rat. In The Physiology of Reproduction (E. Knobil and J. Neill, Eds.), pp. 363-410. Raven Press, New York.
32. Yaish, P., A. Gazit, C. Giion, and A. Levitzki (1988). Blocking of EGF-depending cell proliferation by EGF receptor kinase inhibitors. Science 242: 933-935.
33. Lyall, R. M., A. Zilberstein, A. Gazit, C. Gilon, A. Levitzki, and J. Schlessinger (1989). Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J. Biol. Chem. 264: 14503-14509.
34. Ma, Y. J., M. Junier, M. E. Costa, and S. R. Ojeda (1992). Transforming growth factor alpha (TGFn) gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron 9: 657-670.
35. Junier, M., Y. J. Ma, M. E. Costa, G. Hoffman, D. F. Hill, and S. R. Ojeda (1991). Transforming growth factor alpha contributes to the mechanism by which hypothalamic injury induces precocious puberty. Proc. Natl. Acad. Sci USA 88: 9743-9747.
36. Petch, L. A., J. Harris, V. W. Raymond, A. Blasband, D. C. Les, and H. S. Earp (1990). A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue. Mol. Cell. Biol 10: 2973-2982.
37. Kris, R. M., I. Lax, W. Gullick, M. D. Waterfield, A. Ullrich, M. Fridkin, and J. Schlessinger (1985). Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Cell 40: 619-625.
38. Ma, Y. J., M. Junier, D. F. Hill, S. Felder, and S. R. Ojeda (1991). Expression of the transforming growth factor alpha (TGFa)-epidermal growth factor (EGF) receptor system in the developing female hypothalamus: Changes during the onset of puberty. Proc. 73rd Annu. Meet. Endocrine Soc., p. 303. [Abstract]
39. Junier, M., D. F. Hill, M. E. Costa, S. Felder, and S. R. Ojeda (1993). Hypothalamic lesions that induce female precocious puberty activate glial expression of the epidermal growth factor receptor gene: Differential regulation of alternatively spliced transcripts. J. Neurosci. 13: 703-713.
40. Lara, H. E., D. F. Hill, K. H. Katz, and S. R. Ojeda (1990). The gene encoding nerve growth factor is expressed in the immature rat ovary: Effect of denervation and hormonal treatment. Endocrinology 126: 357-363.
41. Chomczynski, P., and N. Sacchi (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
42. Sherman, T. G., J. F. McKelvy, and S. J. Watson (1986). Vasopressin mRNA regulation in individual hypothalamic nuclei: A Northern and in situ hybridization analysis. J. Neurosci. 6: 1685-1694.
43. Ojeda, S. R., D. F. Hill, and K. H. Katz (1990). The genes encoding nerve growth factor and its receptor are expressed in the developing female rat hypothalamus. Mol. Brain Res. 9: 47-55.
44. Maniatis, T., E. F. Fritsch, and J. Sambrock (1982). Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, New York.
45. Gilman, M. (1989). Ribonuclease protection assay. In Current Protocols in Molecular Biology, Vol. 1 (F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, Eds.), pp. 4.7.1-4.7.6. Green Publishing and Wiley-Interscience, New York.
46. Hill, D. F., G. A. Dissen, Y. J. Ma, and S. R. Ojeda (1992). Detection of nerve growth factor and one of its receptors. In Methods in Neurosciences, Vol 9: Gene Expression in Neural Tissues (P. M. Conn, Ed.), pp. 179-196. Academic Press, New York.
47. Wang, A. M., M. V. Doyle, and D. F. Mark (1989). Quantitation of mRNA by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 86: 9717-9721.
48. Danielson, P. E., S. Forss-Petter, M. A. Brow, L. Calavetta, J. Douglass, R. J. Milner, and J. G. Sutcliffe (1988). plBl5: A cDNA clone of the rat mRNA encoding cyclophilin. DNA 7: 261-267.
49. Correa-Rotter, R., C. N. Mariash, and M. E. Rosenberg (1992). Loading and transfer control for Northern hybridization. Bio techniques 12: 154-158.
50. Simmons, D. M., J. L. Arriza, and L. W. Swanson (1989). A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes. J. Histotechnol. 12: 169-181.
51. Dissen, G. A., D. F. Hill, M. E. Costa, Y. J. Ma, and S. R. Ojeda (1991). Nerve growth factor receptors in the peripubertal rat ovary. Mol. Endocrinol. 5: 1642-1650.
52. Nilaver, G., and G. P. Kozlowski (1989). Comparison of the PAP and ABC immunocytochemical techniques. In Techniques in Im-munocytochemistry, Vol. 4 (G. R. Bullock and P. Petrusz, Eds.), pp. 199-215. Academic Press, New York.
53. Suarez-Quian, C. A., M. Dai, M. Onoda, R. M. Kriss, and M. Dym (1989). Epidermal growth factor receptor localization in the rat and monkey testes. Biol. Reprod. 41: 921-932.
54. Lakos, S., and A. I. Basbaum (1986). Benzidine dihydrochloride as a chromogen for single- and double-label light and electron microscopic immunocytochemical studies. J. Histochem. Cytochem. 34: 1047-1056.
55. Urbanski, H. F. (1991). Monoclonal antibodies to luteinizing hormone-releasing hormone: Production, characterization, and immunocytochemical application. Biol. Reprod. 44: 681-686.
56. Xu, Y., S. Ishii, A. J. L. Clark, M. Sullivan, R. K. Wilson, D. P. Ma, M. A. Roe, G. T. Merlino, and I. Pastan (1984). Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature 309: 806-810.
57. Ullrich, A., L. Coussens, J. S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, J. Downward, E. L. V. Mayes, N. Whittle, M. D. Waterfield, and P. H. Seeburg (1984). Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309: 418-425.
58. Lin, C. R., W. S. Chen, W. Kruiger, L. S. Stolarsky, W. Weber, R. M. Evans, I. M. Verma, G. N. Gill, and M. G. Rosenfeld (1984). Expression cloning of human EGF receptor complementary DNA: Gene amplification and three related messenger RNA products in A431 cells. Science 224: 843-848.
59. Merlino, G. T., S. Ishii, J. Whang-Peng, T. Knutsen, Y. Xu, A. J. L. Clark, R. H. Stratton, R. K. Wilson, D. P. Ma, B. A. Roe, J. H. Hunts, N. Shimizu, and I. Pastan (1985). Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells. Mol. Cell. Biol. 5:1722-1734.
60. Spaargaren, M., L. H. K. Defize, J. Boonstra, and S. W. de Laat (1991). Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase. J. Biol. Chem. 266: 1733-1739.
61. Pruss, R. M., and H. R. Herschman (1977). Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proc. Natl Acad. Sci. USA 74: 3918-3921.
62. Schneider, C. A., R. W. Lim, E. Terwilliger, and H. R. Herschman (1986). Epidermal growth factor-nonresponsive 3T3 variants do not contain epidermal growth factor receptor-related antigens or mRNA. Biochemistry 83: 333-336.
63. Mayes, E. L. V., and M. D. Waterfield (1984). Biosynthesis of the epidermal growth factor receptor in A431 cells. EM BO J. 3: 531-537.
64. Weber, W., G. N. Gill, and J. Spiess (1984). Production of an epidermal growth factor receptor-related protein. Science 224: 294-297.
65. Nieto-Sampedro, M. (1988). Astrocyte mitogen inhibitor related to epidermal growth factor receptor. Science 240: 1784-1786.
66. Hurwitz, D. R., S. L. Emanuel, M. H. Nathan, N. Sarver, A. Ullrich, S. Felder, I. Lax, and J. Schlessinger (1991). EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain. J. Biol. Chem. 266: 22035-22043.
67. Knowles, F. (1972). Ependyma of the third ventricle in relation to pituitary function. Prog. Brain Res. 38: 255-270.
68. Bleier, R. (1972). Structural relationship of ependymal cells and their processes within the hypothalamus. In Brain-Endocrine Interaction, Median Eminence: Structure and Function (K. M. Knigge, D. E. Scott, and A. Weindl, Eds.), pp. 306-318. Karger, Basel.
69. Kozlowski, G. P., and P. W. Coates (1985). Ependymoneuronal specializations between LHRH fibers and cells of the cerebroven-tricular system. Cell Tissue Res. 242: 301-311.
70. Kraus, M. H., W. Issing, T. Miki, N. C. Popescu, and S. A. Aaronson (1989). Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. USA 86: 9193-9197.
71. Plowman, G. D., G. S. Whitney, M. G. Neubauer, J. M. Green, V. L. McDonald, G. J. Todaro, and M. Shoyab (1990). Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc. Natl. Acad. Sci. USA 87; 4905-4909.
72. 125I] epidermal growth factor binding and receptor distribution in psoriasis. J. Invest. Dermatol. 86: 260-265.
73. Kobayashi, H., H. Yasuda, H. Matsue, A. Ohkawara, Y. Ogiso, and N. Kuzumaki (1990). Epidermal growth factor receptor mRNA is not increased in psoriatic skin. J. Dermatol. 17: 104-107.
74. Silverman, A. (1988). The gonadotropin-releasing hormone (GnRH) neuronal systems: Immunocytochemistry. In The Physiology of Reproduction (E. Knobil, J. D. Neill, L. L. Ewing, G. S. Greenwald, C. L. Markert, and D. W. Pfaff, Eds.), pp. 1283-1304, Raven Press, New York.
75. Wilcox, J. N., and R. Derynck (1988). Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. J. Neurosci. 8: 1901-1904.
76. Hompes, P. G. A., I. Vermes, F. J. H. Tilders, and J. Schoemaker (1982). In vitro release of LHRH from the hypothalamus of female rats during prepubertal development. Neuroendocrinology 35: 8-12.
77. Ojeda, S. R., and V. D. Ramirez (1972). Plasma levels of LH and FSH in maturing rats: Response to hemigonadectomy. Endocrinology 90: 466-472.
78. Carpenter, G. (1987). Receptors for epidermal growth factor and other polypeptide mitogens. Annu. Rev. Biochem. 56: 881-914.
79. Olashaw, N. E., E. J. O’Keefe, and W. J. Pledger (1986). Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters. Proc. Natl. Acad. Sci USA 83: 3834-3838.
80. Spivak-Kroizman, T., D. Rotin, D. Pinchasi, A. Ullrich, J. Schlessinger, and I. Lax (1992). Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. J. Biol. Chem. 267: 8056-8063.
81. Earp, H. S., K. S. Austin, J. Blaisdell, R. A. Rubin, K. G. Nelson, L. W. Lee, and J. W. Grisham (1986). Epidermal growth factor (EGF) stimulates EGF receptor synthesis. J. Biol. Chem. 261: 4777-4780.
82. Bjorge, J. D., A. J. Paterson, and J. E. Kudlow (1989). Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-α in a breast cancer cell line. J. Biol. Chem. 264: 4021-4027.
83. Gardner, R, M. G. Verner, J. L. Kirkland, and G. M. Stancel (1989). Regulation of uterine epidermal growth factor (EGF) receptors by estrogen in the mature rat and during the estrous cycle. J. Steroid Biochem. 32: 339-343.
84. Mukku, V. R., and G. M. Stancel (1985). Regulation of epidermal growth factor receptor by estrogen. J. Biol. Chem. 260: 9820-9824.
85. 2) release. Soc. Neurosci. Abstr. 19: 1682.