Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations

Science

Volumn 264, Issue 5162, 1994, Pages 1152-1156

  Marsh, David G ^a   Neely, John D ^a   Breazeale, Daniel R ^b   Ghosh, Balaram ^a   Freidhoff, Linda R ^a   Ehrlich Kautzky, Eva ^a   Schou, Carsten ^c   Krishnaswamy, Guha ^a   Beaty, Terri H ^b  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c ALK ABELLÓ   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 4;

ARTICLE; CHROMOSOME 5Q; GENETIC LINKAGE; GENETIC MARKER; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SERUM;

EID: 0028230946     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.8178175     Document Type: Article

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69. m repeat in intron 2 of IL4 (35) was also analyzed by agarose gel electrophoresis (19). The length for the shortest, most common allele of 1L4-R1 corresponds to that reported (35).
70. We wish to thank the Amish families for their willingness to participate in this study, W. Bias for providing cell and plasma samples from certain Amish families, R. Hamilton for help with the total IgE analyses, J. York-Blasser, RN, and S. Beiler for fieldwork, C. Stewart and G. Hansen for technical assistance, S.-K. Huang and B. Catipovic for discussions, and CIBA-Corning for provision of equipment. This research was supported by NIH grant AI20059. The program package S.A.G.E. is supported by USPHS resource grant 1 P41 RR03655 from the Division of Research Resources.