Quantitation of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma and cerebrospinal fluid using solid-phase extraction and high-performance liquid chromatography with electrochemical detection

Therapeutic Drug Monitoring

Volumn 16, Issue 2, 1994, Pages 200-208

  Wright, Andrew W E ^a   Watt, Julie A ^a   Kennedy, Michelle ^a   Cramond, Tess ^a   Smith, Maree T ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Electrochemical detection; High performance liquid chromatography; Morphine; Morphine 3 glucuro nide; Morphine 6 glucuronide; Solid phase extraction

Indexed keywords

HYDROMORPHONE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ANIMAL EXPERIMENT; ARTICLE; CANCER PAIN; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG MONITORING; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCHEMISTRY; HUMAN; MORPHINE; MORPHINE DERIVATIVES; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0028230116     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/00007691-199404000-00016     Document Type: Article

References (30)

1. Brunk SF, Delle M. Morphine metabolism in man. Clin Pharmacol Ther1974;16:51-57.
2. Labella FS, Pinsky C, Harlicek V. Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity. Brain Res1979;174:263-271.
3. Yaksh TL, Harty GJ, Onofrio BM. High doses of spinal morphine produce a non-opiate receptor-mediated hyperesthesia: clinical and theoretic implications. Anesthesiology1986;64:590-597.
4. Smith MT, Watt JA, Cramond T. Morphine-3-glucuro-nide—a potent antagonist of morphine analgesia. Life Sci1990;47:579-586.
5. Gong Q-L, Hedner J, Bjorkman R, Hedner T. Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat. Pain1992;48:249-255.
6. Gong Q-L, Hedner T, Hedner J, Bjorkman R, Nordberg G. Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuro-nide. Eur J Pharmacol1991;193:47-56.
7. Shimomura K, Kamata O, Ueki S, et al. Analgesic effect of morphine glucuronides. Tohuku J Exp Med1971;105:45-52.
8. Abbott Fv, Palmour RM. Morpbine-6-glucuromde: analgesic effects and receptor binding profile in rats. Life Sci 1988;43:1685-95.
9. Osborne RJ, Joel S, Slevin MC. Morphine intoxication in renal failure: the role of morphine-6-glucuronide. Br Med J1986;292:1548-1549.
10. Hanna MH, Peat SJ, Woodham M, Knibb A, Fung C. Analgesic efficacy and CSF pharmacokinetics of intrathecal M6G in comparison with morphine. Br J Anaesthiol1990; 64:547-550.
11. Wasels R, Belleville F, Paysant P, Nabet P. Determination of morphine in plasma by gas chromatography using a macrobore column and thermoionic detection after Extrelut column extraction: application to follow-up morphine treatment in cancer patients. J Chromatogr1989;489:411-8.
12. Brose WG, Tanelian DL, Brodsky JB, Mark JBD, Cousins MJ. CSF and blood pharmacokinetics of hydromorphone and morphine following lumbar epidural administration. Pain1991;45:11-15.
13. Spector S, Parker CW. Morphine: radioimmunoassay. Science1970;168:1347-1348.
14. Bouquillon AI, Freeman D, Moulin DE. Simultaneous solid-phase extraction and chromatographic analysis of morphine and hydromorphone in plasma by high-performance liquid chromatography with electrochemical detection. J Chromatogr1992;577:354-357.
15. Moore RA, Baldwin D, McQuay HJ, Bullingham RES. HPLC of morphine with electrochemical detection: analysis in human plasma. Ann Clin Biochem1984;21:125-30.
16. Mason JL, Ashmore SP, Aitkenhead AR. Simple method for the determination of morphine and its active metabolite in human plasma by high-performance liquid chromatography with electrochemical detection. J Chromatogr1990;570: 191-197.
17. Owen JA, Sitar DS. Morphine analysis by high-performance liquid chromatography. J Chromatogr1983;276:202-207.
18. Turner CA, Murphy R. Rapid high-sensitivity method for measurement of morphine in guinea-pig serum. J Chromatogr1988;428:383-7.
19. Olsen GD, Ousley PJ, Mathis MD. Fetal lamb clearance of morphine as determined by high-performance liquid chromatography with electrochemical detection. Neuropeptides1984;5:77-80.
20. Svensson J-O, Rane A, Sâwe J, Sjôqvist F. Determination of morphine, morphine-3-glucuronide and (tentatively) mor-phine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography. J Chromatogr1982; 230:427-432.
21. Milne RW, Nation RL, Reynolds GD, Somogyi AA, Crugten JTV. High-performance liquid chromatographic determination of morphine and its 3- and 6-glucuronide metabolites: improvements to the method and application to stability. J Chromatogr1991;565:457-464.
22. Chari G, Gulati A, Bhat R, Tebbett, IR. High-performance liquid chromatagraphic determination of morphine, mor-phine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multi-wavelength forward optical detection. J Chromatogr1991;571:263-270.
23. Glare PA, Walsh TD, Pippenger CE. A simple, rapid method for the simultaneous determination of morphine and its principle metabolites in plasma using high-performance liquid chromatography and fluorometric detection. Ther Drug Monit1991;13:226-232.
24. Venn RF, Michalkiewicz A. Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection. J Chromatogr1990;525:379-388.
25. Svensson J-O. Determination of morphine, morphine-6-glucuronide and normorphine in plasma and urine with high-performance liquid chromatography and electrochemical detection. J Chromatogr1986;375:174-178.
26. Konishi M, Hashimoto H. On-line clean-up system of plasma sample for simultaneous determination of morphine and its metabolites in cancer patients by high-performance liquid chromatography. J Pharmac Sci1990;79:379-383.
27. Joel SP, Osborne RJ, Slevin ML. An improved method for the simultaneous determination of morphine and its principle metabolites. J Chromatogr1988;430:394-399.
28. Bogusz M. High-performance liquid chromatographic determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multiwavelength forward topical detection: a reply. J Chromatogr1992;579:189-190.
29. Coughtrie MWH, Ask B, Rane A, Burchell B, Hume R. The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyl-transferase isoenzyme. Biochem Pharmacol1989;38:3273-3280.
30. Tan T, Kuramoto M, Takashashi T, et al. Characteristics of the gastrointestinal absorption of morphine in rats. Chem Pharm Bull1989;37:168-173.