Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

Environmental and Molecular Mutagenesis

Volumn 23, Issue 4, 1994, Pages 239-273

  Salamone, Michael F ^a   Mavournin, Kathleen H ^b  

^a ONTARIO MINISTRY OF THE ENVIRONMENT   (Canada)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

baseline or spontaneous frequencies; data summary; distribution profiles; hybrid mice; inbred mice; micronuclei; mouse stocks; mouse strains; negative control; regulatory decisions; vehicle control

Indexed keywords

BONE MARROW; CONTROL; MICRONUCLEUS TEST; MOUSE; NONHUMAN; REVIEW; STRAIN DIFFERENCE;

ANIMAL; BONE MARROW; BONE MARROW CELLS; DATABASES, BIBLIOGRAPHIC; ERYTHROCYTES; GENE FREQUENCY; HYBRIDIZATION, GENETIC; MICE; MICE, INBRED STRAINS; MICRONUCLEUS TESTS; MUTATION; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS;

EID: 0028229919     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.2850230402     Document Type: Review

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173. Effects of azoben‐zene and aniline in the rodent bone marrow micronucleus assay
174. In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline
175. Studies on the modulation of the effects of colchicine by L‐cysteine using bone marrow of Swiss mice
176. Bio‐antimutagenic effect of L‐cysteine on diiodohydroxyquinoline‐induced micronuclei in Swiss mice
177. Modulation of cyclophosphamide mutageniciy by Vit C in the in vivo rodent micronucleus assay
178. Lack of mutagenic activity of white spirit
179. Mutagenicity of cosmetics ingredients licensed by the European Communities
180. Mutagenicity study of fried sausages in Salmonella, Drosophila and mammalian cells in vitro and in vivo.
181. Further evidence of the clastogenic property of erythrosine
182. Relationship between experimental results in mammals and man. 1. Cytogenetic analysis of bone marrow injury induced by a single dose of cyclophosphamide
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186. Effect of food and water deprivation on the parameters of the mouse bone marrow micronucleus test
187. Mutagenic effects of dimethyl terephthalate on mouse somatic cells in vivo.
188. Micronucleus formation in bone marrow of mice treated with nifurtimox or benznidazole
189. Mutagenicity testing of irradiated onions in mice
190. Assessment of the in vivo aneuploidy/micronucleus assay in bone marrow cells with 16 chemicals
191. Comparison of single‐, double‐ or triple‐exposure protocols for the rodent bone marrow/peripheral blood micronucleus assay using 4‐aminobiphenyl and treosulfan
192. Micronucleus induction in mouse bone marrow by phenacetin administered intraperitoneally or orally
193. Effects of quinoline and 8‐hydroxyquinoline on mouse bone marrow erythrocytes as measured by the micronucleus assay
194. Inhibition by germanium oxide of the mutagenicity of cadmium chloride in various genotoxicity assays
195. Micronucleus test with 6‐mercaptopurine monohydrate administered intraperitoneally and orally
196. Pyridine prevents the clastogenicity of benzene but not of benzo(a)pyrene or cyclophosphamide
197. The influence of simple aromatics on benzene clastogenicity
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202. Metronidazole exhibits no cytogenetic effect in the micronucleus test in mice or on human lymphocytes in vitro.
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206. An application of acridine orange fluorescent staining to the micronucleus test
207. Use of historical control data for assessing micronucleus test data
208. Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals
209. The micronucleus test in mutagen sensitive MS/Ae mice
210. Micronucleus test with 1‐beta‐D‐arabinofurnosylcytosine administered by intraperitoneal injection and oral gavage
211. A procedure for data analysis of the rodent micronucleus test involving a historical control
212. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange‐coated slides
213. Simulation study of the effects of multiple treatments in the mouse bone marrow micronucleus test
214. Mouse bone marrow micronucleus test using flow cytometry
215. The assessment of mutagenicity: Health Protection Branch mutagenicity guidelines
216. The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene‐Tox Program
217. Cytogenetic effects of Cuman L, a dithiocarbamate fungicide
218. Effects of diethylstilboestrol‐dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo.
219. Sex difference in sensitivity to the cytogenetic effects of ethyl methanesulfonate in mice demonstrated by the micronucleus test
220. Testing natural indigo for genotoxicity
221. The mutagenicity evaluation of MT‐141, a new cephamycin
222. Mutagenic evaluation of ronidazole
223. Mutagenic evaluation of nitroparaffins in the Salmonella typhimurium/mammalian microsome test and the micronucleus test
224. The effect of benzene in the micronucleus test
225. Micronucleus test on quinacrine dihydrochloride in mice: A comparison of dosage regimens
226. Induction of micronuclei in bone marrow of mice exposed to 1, 2 or 3 daily doses of urethane
227. Micronucleus induction by camptothecin and amsacrine in bone marrow of male and female CD‐1 mice
228. 4CMB, 3HMB and BC evaluated by the micronucleus test using a multiple sampling method
229. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions
230. A study on genotoxicity of cooking fume from rapeseed oil
231. Rapid detection of mutagen induced micronucleated erythrocytes by flow cytometry
232. Micro‐nucleus test of DWA2114R
233. Suppression of mitomycin C‐induced micronuclei in mouse bone marrow cells by post‐treatment with vanillin
234. Micronucleus test with procarbazine hydrochlo‐ride administered by intraperitoneal injection and oral gavage
235. Mutagenic evaluation of etintidine (BL‐5641), a novel histamine H2‐receptor antagonist, using the chromosome aberration test in CHL cells and the micronucleus test in mice
236. Negative micronucleus tests on caprolactam and benzoin in ICR/JCL male mice
237. The micronucleus test in strain C57BL/6J mice
238. Mutagenicity studies of cadexomer iodine, a drug for treatment of dermal ulcer, and cadexomer, basic polymer
239. Cytogenetic investigations on mice treated with lead
240. Frequency of micronucleated cells in the mouse bone marrow after exposure to various doses of gamma‐radiation
241. Effect of chlorpromazine hydrochloride on the formation of micronuclei in the bone marrow of mice exposed to gamma radiation
242. Inhibition of clastogenic effect of radiation by Liv.52 in the bone marrow of mice
243. Effect of copperglycinate on the radiation induced micronuclei formation in mice bone marrow
244. Vinblastine treatment induces dosedependent increases in the frequency of micronuclei in mouse bone marrow
245. Micronucleus test on benzo(a)pyrene and pyrene performed in NMRI mice
246. Micronucleus test in bone marrow cells of CBA male mice
247. Dose response at low doses of X‐irradiation and MMS on the induction of micronuclei in mouse erythroblasts
248. Factors affecting the induction of micronuclei at low doses of X‐rays, MMS and dimethylnitrosamine in mouse erythroblasts
249. Distribution and cytogenetic test of 2,4‐D and 2,4,5‐T phenoxyacetic acids in mouse blood tissues
250. The induction of micronuclei by frameshift mutagens at the time of nucleus expulsion in mouse erythroblasts
251. Comparison of clastogenicity of inorganic Mn administered in cationic and anionic forms in vivo.
252. Evaluation of the genotoxic potential of sorbic acid and potassium sorbate
253. Mutagenicity tests with a surfactant formulation, Toximul MP‐8, in Drosophila and mouse bone marrow cells
254. Dominant lethality and micronuclei in mice treated with diazepam
255. Mutagenic evaluation of tolbutamide and glybenclamide on the bone marrow cells of mice
256. Genotoxicity studies on mice after short term inhalation exposure to methyl isocyanate
257. Mutagenicity testing of condensates of smoke from titanium dioxide/hexachloroethane and zinc/hexachloroethane pyrotechnic mixtures
258. Genotoxic activity of 1‐chloromethylpyrene in stomach epithelium in vivo: Insensitivity of the stomach scintillation UDS assay
259. Transplacental mutagenesis: Micronucleus test on fetal mouse blood
260. The mutagenic potential of hyperthermia and fever in mice
261. Mutagenicity studies with X‐ray‐contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems
262. Micronucleus test on 21 compounds
263. Genetic toxicology testing requirements: Official and unofficial views from Europe
264. Validation of the mouse peripheral blood micronucleus assay using acridine orange supravital staining with urethane
265. Micronucleus test in bone marrow of mice treated with 1‐nitropropane, 2‐nitropropane and cisplatin
266. Induction of micronuclei in polychromatic erythrocytes in bone marrow of adult 1C3F1 hybrid male mice
267. Sex differences in micronucleus induction with hycanthone methanesulfonate in bone marrow cells of mice
268. Micronucleus test and bone‐marrow chromosome analysis. A comparison of 2 methods in vivo for evaluating chemically induced chromosomal alterations
269. Induction of chromosome damage in mouse bone marrow by benzo(a)pyrene
270. Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria
271. In vitro and in vivo assays of isopropanol for mutagenicity
272. Micronucleus test with ethyl methanesulfonate administered by intraperitoneal injection and oral gavage
273. Mutagenic and clastogenic activity of the chloro‐nitroimidazole radiosensitizer P40 in vitro and in vivo.
274. In vivo cytogenetic studies on mice exposed to ethylene dibromide
275. Dimethylnitrosamine‐induced micronucleus formation in mouse bone marrow and spleen
276. Simultaneous evaluation of clastogenicity, aneugenicity and toxicity in the mouse micronucleus assay using immunofluorescence
277. Comparative micronucleus quantitation in pre‐ and post‐column fractionated mouse bone marrow by manual and flow methods
278. Testing of 2,4,5‐ and 2,4,6‐trimethylaniline in the Salmonella assay, in mammalian cell cultures, and in Drosophila melanogaster and comparison of the results with carcinogenicity data
279. Mutagenicity of extracts of brown and black masheri, pyrolyzed products of tobacco using short‐term tests
280. Mutagenicity studies with safrotin in Drosophila melanogaster and mice
281. Modulatory effects of clove (Caryophyllus aromatic L.) on hepatic detoxification systems and bone marrow genotoxicity in Swiss albino mice
282. Modulatory influences of mace (Myristica fragrans, Holtt.) on hepatic detoxification systems and bone marrow genotoxicity in male Swiss albino mice
283. Toxikologische untersuchungen mit Tramadol, einem neuen analgetikum
284. In vivo and in vitro cytogenetic effects of the anti‐tumor agent amsacrine (AMSA)
285. Etoposide and Teniposide: In vivo and in vitro genotoxic studies
286. Mutagenicity tests with griseofulvin
287. Mutagenicity of acrylonitrile in mouse
288. Safety evaluation studies of SGF gum: A potential food additive from the seed of Sesbania cannabina.
289. Lack of genotoxic effects of fluoride in the mouse bone‐marrow micronucleus test
290. Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxic streptozotocin
291. Mutagenicity studies on FD&C Red No. 3
292. Comparative study of the genotoxic properties of eastern and western U.S. shale oils, crude petroleum, and coal‐derived oil
293. An experimental approach to identifying the genotoxic risk from cooked meat mutagens
294. Genotoxicity studies in vitro and in vivo on carminic acid (natural red 4)
295. Induction of covalent DNA modifications and micronucleated erythrocytes by 4‐nitroquinoline 1‐oxide in adult and fetal mice
296. Cytosar‐induced micronuclei and chromosomal aberrations in mouse bone‐marrow cells
297. Chromosomal aberrations and micronuclei induced in rat and mouse bone marrow cells by sodium nitrate
298. In vivo and in vitro cytogenetic damage induced by sodium nitrite
299. The so‐called Swiss mouse
300. Mutagenicity tests of diflubenzuron in the micronucleus test in mice, the L5178Y mouse lymphoma forward mutation assay, and the Ames Salmonella reverse mutation test
301. In vivo exposure to plant flavonols: Influence on frequencies of micronuclei in mouse erythrocytes and sister‐chromatic exchange in rabbit lymphocytes
302. Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine
303. Mutagenicity studies with praziquantel, a new anthelmintic drug, in mammalian systems
304. Species differences in mutagenicity testing. 1. Micronucleus and SCE tests in rats, mice, and Chinese hamsters with aflatoxin B1
305. Induction of micronuclei by vinyl acetate in mouse bone marrow cells and cultured human lymphocytes
306. Toxicological studies with dithranol and its 10‐acyl analogs
307. Inhibition of benzo(a)pyrene‐induced bone marrow micronuclei formation by diallyl thioethers in mice
308. In vitro and in vivo evaluation of the genotoxicity of N‐nitrosooxprenolol
309. Comparison of micronucleus formation in mouse bone marrow and spleen
310. In vivo genotoxic effects in mice of Metacid 50, an organophosphorus insecticide
311. Failure to detect chromosome damage in bone‐marrow cells of mice and Chinese hamsters exposed in vivo to some ergot derivatives
312. Genotoxicity evaluation of cyclosporin A, a new immunosuppressive agent
313. Mutagenicity evaluation of thioridazine
314. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene‐Tox Program
315. Assays of three carcinogen/non‐carcinogen chemical pairs for in vivo induction of chromosome aberrations, sister chromatid exchanges and micronuclei
316. Recovery of polychromatic erythrocytes and micronuclei following cellulose column separation of mouse bone‐marrow samples
317. In vivo cytogenetic activity of diphenylhydantoin in mice
318. Evaluation of chemicals used for drinking water disinfection for production of chromosomal damage and sperm‐head abnormalities in mice
319. Mutagenic and clastogenic properties of 3‐chloro‐4‐(dichloromethyl)‐5‐hydroxy‐2(5H)‐furanone: A potent bacterial mutagen in drinking water
320. Activity of 1,2‐dimethylhydrazine in the mouse bone marrow micronucleus assay using a triple‐ and a single‐dosing protocol
321. An evaluation of the mutagenic potential of cyanamide using the micronucleus test
322. Mutagenicity of urine of bidi and cigarette smokers and tobacco chewers
323. In vitro and in vivo studies on the potential mutagenicity of alclofenac, dihydroxyalclofenac and alclofenac epoxide
324. Absence of povidone‐iodine‐induced mutagenicity in mice and hamsters
325. N,N‐Diethylphenylacetamide, an insect repellent: absence of mutagenic response in the in vitro Ames test and in vivo mouse micronucleus test
326. Cytogenetic activity of methyl isocyanate in vivo in the mouse micronucleus test
327. Sex‐related differences in cytogenetic effects of benzene in the bone marrow of Swiss mice
328. Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes
329. Activity of the human carcinogens benzidine and 2‐naphthylamine in triple‐ and single‐dose mouse bone marrow micronucleus assays: Results for a combined test protocol
330. Relative distribution of mature erythrocytes, polychromatic erythrocytes (PE) and micronucleated PE on mouse bone‐marrow smears: Control observations
331. Activity of the human carcinogens benzidine and 2‐naphthylamine in male mouse bone marrow micro‐nucleus assays
332. Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S‐phase synthesis, or micronuclei following in vivo treatment with multiple doses
333. Clastogenic potential testing of some hair dye components by bone marrow micronucleus analysis
334. Genetic toxicological testing of some dyes by the micronucleus test
335. Investigations into parametric analysis of data from in vivo micronucleus assays by comparison with non‐parametric methods
336. The detection and importance of outliers in the in vivo micronucleus assay
337. Administration‐route‐related difference in the micronucleus test with 7, 12‐dimethylbenz(a)anthracene
338. Effects of ethylbenzene, toluene, and xylene on the induction of micronuclei in bone marrow polychromatic erythrocytes of mice
339. Clastogenic effect of passive smoking on bone marrow polychromatic erythrocytes of NMRI mice
340. The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice
341. Comparative bone marrow clastogenicity of cigarette sidestream, mainstream and recombined smoke condensates in mice
342. Genetic toxicity of dopamine
343. Nitrilotriacetic acid (NTA) does not induce chromosomal damage in mammalian cells either in vitro or in vivo
344. The effect of diphenylhydantoin on the frequency of micronuclei in bone‐marow polychromatic erythrocytes of mice
345. Coumarin inhibits micronuclei formation induced by benzo(a)pyrene in male but not female ICR mice
346. Genotoxic effects of fly ash in bacteria, mammalian cells and animals
347. Radioprotective effects of cimetidine in mouse bone marrow cells exposed to X‐rays as assayed by the micronucleus test
348. Mutagenic bioassay of certain pharmacological drugs. 1. Thiabendazole (TBZ)
349. Mutagenic evaluation of chlorpropamide in mice by the micronucleus test
350. Relative efficacy of short‐term tests in detecting genotoxic effects of cadmium chloride in mice in vivo.
351. Sister chromatid exchanges and micronuclei formations induced by sorbic acid and sorbic acid‐nitrite in vivo in mice
352. Anticlastogenic activity of beta‐carotene against cyclophosphamide in mice in vivo.
353. Micronucleus induction in mouse and rat fetuses treated transplacentally during histogenesis with mitomycin C and 7,12‐dimethylbenz(a)anthracene
354. Mouse micronucleus assays of sporidesmin, the toxin associated with facial eczema in ruminants
355. Mutagenicity testing of quinine with submammalian and mammalian systems
356. Re‐examination of potassium sorbate and sodium sorbate for possible genotoxic potential
357. Assessment of in vivo mutagenic potency of ethylenediaminetetraacetic acid in albino mice
358. Frequency and types of induced and spontaneous chromosome aberrations in relation to cell kinetics
359. Mutagenicity of chili extract and capsaicin in short‐term tests
360. Effect of estrogen on induction of micronuclei by mutagens in male mice
361. Effect of route of administration in the micronucleus test with potassium bromate
362. Evaluation of the mutagenicity of formaldehyde in mammalian cytogenetic assays in vivo and in vitro.
363. Benzene‐induced micronuclei formation in mouse fetal liver blood, peripheral blood, and maternal bone marrow cells
364. Styrene and vinyl toluene induce micronuclei in mouse bone marrow
365. Mutagenicity studies on ketone solvents: Methyl ethyl ketone, methyl isobutyl ketone, and isophorone
366. Detection of the cytogenetic effect of inhaled aerosols by the micronucleus test
367. Micro‐nucleus test with vincristine administered by intraperitoneal injection and oral gavage
368. Mutagenicity tests of suplatast tosilate (IPD‐1151T)
369. Genotoxicity studies of rodents exposed to coal dust and diesel emission particulates
370. Mutagenicity studies of aspoxicillin
371. The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: Micronuclei and mitotic index
372. Genetic toxicology studies of an anti‐AIDS drug
373. Genetic toxicology studies with a tumor promoter
374. Origin of aneuploidy in relation to disturbances of cell‐cycle progression. 2. Cytogenetic analysis of various paramenters in mouse bone marrow cells after colchicine or hydroquinone treatment
375. Mutagenic and cytogenetic studies of N'‐nitrosonornicotine and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone
376. Antimutagenic effects of betel leaf extract against the mutagenicity of two tobacco‐specific N‐nitrosamines
377. Genetic effects of pesticides in the mammalian cells. 1. Induction of micronucleus
378. Mutagenic studies on the insecticide Metasystox‐R with different genetic systems
379. Evaluation of Thimet 10‐G for mutagenicity by 4 different genetic systems
380. The in vivo effect of 2,6‐xylidine on induction of micronuclei in mouse bone marrow cells
381. Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. 1. Effect on the induction of micronuclei in mouse bone marrow cells
382. The evaluation of a multiple dosing protocol for the mouse bone‐marrow micronucleus assay using benzidine and 2,6‐xylidine
383. Expulsion of demecocine‐induced micronuclei from mouse bone marrow polychromatic erythrocytes
384. Chromosome damage induced in vivo by heavy metal ion detected by indirect testing
385. 6+
386. Mutagenic effects of thiram in mammalian somatic cells
387. Inhibition by arsenic trioxide of induction of mutations with thiotepa in mouse somatic and germ cells
388. Experimental study of the antimutagenic properties of 5‐methylresorcinol
389. Increased antimutagenic activity of simple substituted phenols mixed with the hindered phenolic antioxidant dibunol
390. The use of a simple hematoxylin and eosin staining procedure to demonstrate micronuclei within rodent bone marrow
391. Evaluation of genetic toxicity of the insecticide phosphamidon using in vitro and in vivo mammalian test systems
392. Genotoxic effect of an environmental pollutant, sodium fluoride, in mammalian in vivo test system
393. Cytogenetic effects of fenvalerate in mammalian in vivo test system
394. Induction of micronuclei in bone marrow cells of mice treated with phenylbutazone
395. Metaphase analysis, micronuclei assay, and urinary mutagenicity assay of mice exposed to diesel emissions
396. Induction of micronuclei in mouse bone marrow cells: An evaluation of nucleoside analogues used in the treatment of AIDS
397. Cytogenetic effect of the thiocarbamate herbicides butylate, molinate and vernolate in the mouse bone marrow micronucleus test
398. Mutagenic and genotoxic activities of extracts derived from the cooked and raw edible mushroom Agaricus bisporus.
399. Assessment of genotoxic effects of lindane
400. Micronuclei induction in mouse bone marrow cells with benzo(a)pyrene, pyrene, 2‐acetyl‐aminofluorene and 4‐acetylaminofluorene
401. Genotoxic effects of dioxolane and trioxane in mice evaluated by the micronucleus test
402. Genotoxic effects of ethyl acrylate and methyl acrylate in the mouse evaluated by the micronucleus test
403. Mutagenic activity of some textile dyes in different test systems
404. Mutagenic and genotoxic activity of chosen dyes and surface active compounds used in the textile industry
405. Examination of the potential mutagenicity and genotoxicity of some synthetic dyes
406. Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studies by using the micronucleus test
407. Genotoxicity of heated cooking oil vapors
408. Study on toxicology of a new anthelmintic “85012”
409. Cytological effects of khat (Catha edulis) in somatic and male germ cells of mice
410. Inhibitory effect of 7,8‐benzoflavone on DMBA‐ and BaP‐induced bone marrow micronuclei in mouse
411. Corn oil and its minor constituents as inhibitors of DMBA‐induced chromosomal breaks in vivo
412. Beta‐carotene as an inhibitor of benzo(a)pyrene and mitomycin C induced chromosomal breaks in the bone marrow of mice
413. Caffeic acid as an inhibitor of DMBA‐induced chromosomal breakage in mice assessed by bone‐marrow micronucleus test
414. Genotoxicity testing of the herbicide Roundup and its active ingredient glyphosphate isopropylamine using the mouse bone marrow micronucleus test, Salmonella mutagenicity test and Allium anaphase‐telophase test
415. Effects of fluphenazine hydrochloride on the bone‐marrow cells of Swiss mice
416. Cytogenetic effects of ribavirin on mouse bone marrow
417. Modification of benzo(a)pyrene induced chromosomal damage in mouse bone marrow by vitamin A
418. Effect of primidone in somatic and germ cells of mice
419. Clastogenicity of tritiated thymidine to the mouse bone marrow
420. Mutagenicity of secalonic acid D in mice
421. Micronucleus test in mice fed on irradiated whole diet
422. Meeting new challanges in industrial toxicology
423. Antimutagenic effect of an antioxidant in mammals
424. Mutagenic evaluation of single cell protein with various mammalian test systems
425. Attempts to induce cytogenetic effects with sulfite in sulfite oxidase‐deficient Chinese hamsters and mice
426. The possible role of probiotics as dietary antimutagens
427. An investigation of the genetic toxicology of irradiated foodstuffs using short‐term test systems. 3. In vivo tests in small rodents and in Drosophila melanogaster.
428. Evaluation of some formaldehyde‐release compounds and other biocides in the mouse micronucleus test
429. Activity of vinyl chloride monomer in the mouse micronucleus assay
430. A preliminary assessment of the cytogenetic effects of Metepa on mouse bone marrow using the micronucleus test
431. An evaluation of the mutagenic potential of 2‐(2′,4′‐diaminophenoxy) ethanol using the micronucleus test
432. An evaluation of the mutagenic potential of 4‐chloromethylbiphenyl (4CMB) using the micronucleus test
433. The genotoxicity of trenbolone, a synthetic steroid
434. Effect of glutathione on mitomycin C‐induced micronuclei in bone marrow erythrocytes of Swiss albino mice
435. Dithiocarbamate pesticides: Activity of propineb in the micronucleus test in mice
436. The automated bone marrow micronucleus test
437. Genotoxicity studies on Sertaconazole
438. Genotoxic potential of diethylcarbamazine, an antifilarial drug
439. Cytogenetic effect of dapsone, an antileprotic drug, in the mouse in vivo system
440. Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. 2. Micronucleus test in bone marrow and hepatocytes
441. Modification of metal‐induced micronuclei formation in mouse bone marrow erythrocytes by Phyllanthus fruit extract and ascorbic acid
442. Cytogenetic effects of quinalphos in mice
443. Further evidence for the aneuploidogenic properties of chelating agents: Induction of micronuclei in mouse male germ cells by EDTA
444. Identification of kinetochore‐containing (CREST+) micronuclei in mouse bone marrow erythrocytes
445. Genetic toxicological testing of some plant flavonoids by the micronucleus test
446. Mutagenicity of tris(2,3‐dibro‐mopropyl) phosphate in mammalian gonad and bone marrow tissue
447. The bone marrow micronucleus assay: Rationale for a revised protocol
448. Towards an improved micronucleus test. Studies on 3 model agents, mitomycin C, cyclophosphamide and dimethylbenzanthracene
449. Mutagenic activity of 41 compounds in the in vivo micronucleus assay
450. The effects of 5,6‐benzoflavone on the mutagenicity of PAH
451. On the complexities of risk estimates, metabolic activation, and chemical mixtures
452. Tests on two pairs of structural analogs in the mouse in vivo micronucleus assay
453. Micronuclei in adult and foetal mice exposed in vivo to heliotrine, urethane, monocrotaline and benzidine
454. Protective effects of vitamins C and E against gamma rays‐induced chromosomal damage in mouse
455. In vivo anticlastogenic and antimutagenic effects of tannic acid in mice
456. Suppressing effects of vanillin, cinnamaldehyde, and anisaldehyde on chromosome aberrations induced by X‐rays in mice
457. Mouse strain differences in the induction of micronuclei by polycyclic aromatic hydrocarbons
458. A comparison of intraperitoneal injection and oral gavage in the micronucleus test with mitomycin C in mice
459. A comparison of micronucleus induction in 3 mouse strains with representative clastogens
460. Simplified mouse peripheral reticulocyte micronucleus test with dimethylnitrosamine
461. Mouse strain differences in induction of micronuclei by base analogues and nucleosides
462. Cytogenetic studies on 1,1‐dichloroethylene and its two isomers in mammalian cells in vitro and in vivo.
463. Assay‐specific genotoxicity of N‐nitrosodibenzylamine to the rat liver in vivo.
464. Comparison of the activity of topically applied pesticides and the herbicide 2,4‐D in two short‐term in vivo assays of genotoxicity in the mouse
465. Correlations between embryotoxic and genotoxic effects of phenytoin in mice
466. Assay of 4CMB, 4HMC and BC by the micronucleus test—subcutaneous administration
467. In vivo mutagenic interaction of nitrite and ethyl‐enethiourea
468. Development of a method to increase the proportion of polychromatic erythrocytes from mouse bone marrow for more rapid evaluation of the micronucleus assay: Comparison with the conventional method with respect to micronucleus frequency and time required for preparation and evaluation
469. Effect of nitroxazepine on bone marrow cells of mice
470. Methyl carbamate: Negative results in mouse bone marrow micronucleus test
471. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4‐aminobiphenyl, treosulphan, and melphalan
472. Toxicity and mutagenicity of a mixture of 25 chemicals found in contaminated groundwater
473. Mouse dominant lethal and bone marrow micronucleus studies on methyl vinyl sulfone and divinyl sulfone
474. Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals
475. An evaluation of caprolactam and benzoin in the mouse micronucleus test
476. Inactivity of methylene chloride in the mouse bone marrow micronucleus assay
477. Mutagenicity testing of ST‐film with the Ames test, chromosome test in vitro and micronucleus test in female mice
478. Mutagenicity studies of Muroctasin
479. Multiple‐dosing effects of benzo(a)pyrene in the mouse bone marrow micronucleus test
480. Mutagenicity of the new quinolone antibacterial agent levofloxacin
481. Mutagenicity of instant coffee and its interaction with dimethylnitrosamine in the micronucleus test
482. The micronucleus test with mouse spleen cells
483. Micronucleus test with potassium chromate(VI) administered intraperitoneally and orally to mice
484. Mutagenicity of smoke condensate of bidi: An indigenous cigarette of India
485. Mutagenicity of betel quid and its ingredients using mammalian test systems
486. Comparison of mutagenicity of Indian cigarettes and bidi smoke condensates
487. Progestin (norethisterone)‐induced genetic damage in mouse bone marrow
488. Genotoxic effect of Anovlar 21, an oral contraceptive, on mouse bone marrow
489. Influence of vegetable oil vehicles on bone‐marrow proliferation in the mouse micronucleus test
490. Species differences in the genotoxicity of cyclophosphamide and styrene in three in vivo assays
491. Effects of 5‐bromo‐2‐deoxyuridine and 2‐deoxy‐D‐glucose on radiation‐induced micronuclei in mouse bone marrow
492. Activité mutagène du benzène et du benzo(a)pyrène. Mise évidence par la technique des corps de Howell‐Jolly
493. Contribution a la connaissance de l'effet mutagène du benzène. 2. Action de la castration sur la sensibilité de la souris mǎle a l'action mutagène du benzène
494. Evaluation of the clastogenic action of benzene by oral administration with 2 cytogenetic techniques in mouse and Chinese hamster
495. Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay
496. Japanese guidelines for mutagenicity testing
497. Cytogenetics effects of gaseous and volatile chemicals on mammalian cells in vitro and in vivo. II. Micronucleus tests in mice
498. Studies on three structurally related phenylenediamines with the mouse micronucleus assay system
499. Standardized nomenclature for inbred strains of mice: Sixth listing
500. Standardized nomenclature for inbred strains of mice: Eighth listing
501. The transplacental micronucleus test
502. Inbred mice in science
503. A comparison of the incidence of micronuclei in blood and bone marrow in 3 strains of mouse dosed with cyclophosphamide or hexamethylphosphamide (HMPA)
504. Activity of bromochlorodifluoromethane (BCF) in three mutation tests
505. The clastogenic activity of benzo(a)pyrene, pyrene, 2‐acetylaminofluorene and 4‐acetylaminofluorene in the mouse bone marrow micronucleus test
506. Assessment of genotoxicity of two anti‐Parkinsonian drugs (selegilne hydrochloride and bromocryptine mesylate) in vivo in mouse bone marrow cells
507. Micronucleus test with 2‐acetylaminofluorene by intraperitoneal injection and oral administration
508. The micronucleus test of methyl methanesulfonate with mouse peripheral blood reticulocytes using acridine orange‐coated slides
509. Cytogenetic effects of trifluoperazine in mice
510. Genotoxicity of chlordiazepoxide hydrochloride on the bone‐marrow cells of Swiss mice
511. Mutagenicity evaluation of amino‐oxazoline derivatives using in vitro and in vivo short‐term tests
512. Micronucleus incidences induced in bone marrow erythrocytes of pregnant NMRI mice and in liver‐derived erythrocytes of their foetuses
513. Maternal effect on micronucleus induction in MS/Ae mice
514. Administration‐route‐related difference in the micronucleus test with N‐ethyl‐N‐nitrosourea
515. Effects of multiple dosing of phenacetin in the micronucleus test
516. Effect of multiple dosing of phenacetin on micronucleus induction: A supplement to the international and Japanese cooperative studies
517. Administration‐route‐related differences in the micronucleus test with benzene
518. Micronucleus induction in mouse peripheral reticulocytes by 7,12‐dimethylbenz‐[a]anthracene
519. Effect of erythropoietin on the micro‐nucleus test
520. The micronucleus test and erythropoiesis. Effects of erythropoietin and a mutagen on the ratio of polychromatic to normochromatic erythrocytes (P/N ratio)
521. Bacterial reversion assay and micronucleus test carried out on hydrogenated glucose syrups Maltitowa (powder) and maltitol crystal
522. Clastogenic evaluation of cathinone and amphetamine in somatic cells of mice
523. Detection of micro‐nucleated polychromatic erythrocytes in bone marrow of male mice
524. Lack of geno‐toxicity with acrylate polymers in five short‐term mutagenicity assays
525. Methyl isocyanate: An evaluation of in vivo cytogenetic activity
526. Effect of treatment protocol and sample time on the frequencies of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood
527. Genotoxic effects of various chlorinated butenoic acids identified in chlorinated drinking water
528. Influence de l'ǎge sur la radiosensibilité chromosomique des érythrocyte de la moelle osseuse de la souris
529. Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays—including a triple dose study
530. Inactivity of copper sulphate in a mouse bone‐marrow micronucleus assay
531. Activity of the human carcinogen MeC‐CNU in the mouse bone marrow micronucleus assay
532. Micronucleus morphology as a means to distinguish aneugens and clastogens in the mouse bone marrow micronucleus assay
533. Activity of DMBA, DMH and CP in triple‐ and single‐dose rodent bone‐marrow micronucleus assays
534. Toxic effect on mouse bone marrow caused by inhalation of benzene
535. In vivo cytogentic screening methods for mutagens, with special reference to the micronucleus test
536. Activity of coded compounds in the micronucleus test
537. Micronucleus test with methyl methanesulfonate administered by intraperitoneal injection and oral gavage
538. Genotoxic activity of nitrosated coal dust extract in mammalian systems
539. In vivo cytogenetic effects of cooked food mutagens
540. Mechanism on benzene toxicity, effects of benzene and benzene metabolites on bone marrow cellularity, number of granulopoietic stem cells and frequency of micronuclei in mice
541. On the differential responsiveness of males and females in the micronucleus assay
542. Mutagenicity studies involving aldrin, endosulfan, dimethoate, phosphamidon, carbaryl and ceresan
543. Studies on the cytogenetic effects of oxydemetonmethyl in the human leukocyte and mouse micronucleus test systems
544. Mutagenic effect of monocrotophos—an insecticide—in mammalian test systems
545. Effect of hormone treatment on spontaneous and radiation‐induced chromosomal breakage in normal and dwarf mice
546. Clastogenic effects of biosynthetic human growth hormone in Snell dwarf mice and CHO cells in vitro.
547. Effects of hormone treatment on chromosomal radiosensitivity of somatic and germ cells of Snell's dwarf mice
548. A search for radiosensitive mouse mutants by use of the micronucleus technique
549. Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and THC
550. Investigation into the mutagenic activity of azathioprine (Imuran) in different test systems
551. The micronucleus assay as a test for the detection of aneugenic activity
552. Sampling times in micronucleus testing
553. Comparative studies on genotoxic and carcinogenic effects of different cytostatic protocols. I. In vivo cytogenetic analyses in CBA mice
554. Lack of clastogenic effects of irradiated glucose in somatic and germ cells of mice
555. Genotoxic activity of 1,3‐butadiene and nitrogen dioxide and their photochemical reaction products in Drosophila and in the mouse bone marrow micronucleus assay
556. Genetic effects of turmeric and curcumin in mice and rats
557. Mutagens from roasted seeds of Moringa oleifera.
558. The micronucleus test: Methodological aspects
559. Preliminary characterization of the mutagenic properties of necatorin, a strongly mutagenic compound of the mushroom Lactarius necator.
560. Micronucleus test with cyclophosphamide administered by intraperitoneal injection and oral gavage
561. Mutagenic effects of combinations of chemical carcinogens and environmental pollutants in mice as shown by the micronucleus test
562. An evaluation of the micronuclei test using triethylenemelamine, trimethylphosphate, hycanthone and niridazole
563. Genetic difference between two substrains of the inbred 101 mouse strain
564. The differential clastogenicity of Solvent Yellow 14 and FD&C Yellow 6 in vivo in the rodent micronucleus test (observations on species and tissue specificity)
565. Effects of aniline hydrochloride in the mouse bone marrow micronucleus test after oral administration
566. Activity of urethane in rat and mouse micronucleus tests after oral administration
567. 4CMB: Investigation of activity in a mouse micronucleus test
568. Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus test
569. Bone marrow micronucleus tests on NMRI mice
570. Micronucleus induction in bone marrow by vinyl carbamate, a hypothetical metabolite of the carcinogen urethane (ethyl carbamate)
571. Cytogenetic effects of Ortho‐phenylenediamine in the mouse, Chinese hamster and Guinea pig, and of derivatives evaluated by the micronucleus test
572. Genotoxicity study of CS(ortho‐chlorobenzyldenemalononitrile) in Salmonella, Drosophila and mice: Failure to detect mutagenic effects
573. Study of artificial flavoring substance for mutagenicity in the Salmonella/microsomal, BASC and micronucleus tests
574. Differential mutagenic activity of IQ (2‐amino‐3‐methylimidazo(4,5‐f)quinoline) in Salmonella typhimurium strains in vitro and in vivo, in Drosophila, and in mice
575. Induction of chromosomal damage in mammalian cells in vitro and in vivo by sulfapyridine or 5‐aminosalicyclic acid
576. Induction of kinetochore positive and negative micronuclei in mouse bone marrow cells by salicy‐lazosulfapyridine and sulfapyridine
577. Genetic toxicity of the benzene metabolite trans, trans‐muconaldehyde in mammalian and bacterial cells
578. Evaluation of eugenol for mutagenicity by the mouse micronucleus test
579. An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals. A report of the U.S. Environmental Protection Agency Gene‐Tox Program
580. In vivo study on the frequency of sister chromatid exchange (SCE) and micronuclei (MN) induced by cyclophosphamide in bone marrow and spleen cells in rodents
581. Effect of tetrandrine on micronucleus formation and sister chromatid exchange in both in vitro and in vivo assays
582. Studies on micronuclei time response and on the effects of multiple treatments on induction of micronuclei
583. A comparison of diameters of micronuclei induced by clastogens and by spindle poisons
584. A study on the mutagenicity of 102 raw pharmaceuticals used in Chinese traditional medicine
585. Mutagenicity and cytotoxicity tests of garlic
586. Evaluation of the action of clomiphene citrate (Clomid) on mouse chromosomes by the metaphase and micronucleus tests
587. Anticlastogenic and bio‐antimutagenic activity of cultured broth of Saccharomyces cerevisiae 28 on mutagens
588. Influence of cannabinoids on somatic cells in vivo.