Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 14, Issue 7, 1994, Pages 1177-1185

  Hughes, H ^a   Mathews, B ^a   Lenz, M L ^a   Guyton, J R ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

7 ketocholesterol; Cytotoxicity; Oxidized LDL; Oxysterols; Smooth muscle cells

Indexed keywords

7 OXOCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; LIPID ANALYSIS; LIPID OXIDATION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMAL; AORTA; CELL COUNT; CELL DEATH; COPPER; COPPER SULFATE; HYDROXYCHOLESTEROLS; KETOCHOLESTEROLS; LIPIDS; LIPOPROTEINS, LDL; MUSCLE, SMOOTH, VASCULAR; OXIDATION-REDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SWINE;

EID: 0028227192     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.14.7.1177     Document Type: Article

References (8)

1. Esterbauer H, Jurgens G, Quehenberger O, Koller E. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res. 1987;28:495-509.
2. Hessler JR, Morel DW, Lewis LJ, Chisholm GM. Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis. 1983;3:215-222.
3. Morel DW, DiCorleto PE, Chisholm GM. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis. 1984;4:357-364.
4. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci U S A. 1984;81:3883-3887.
5. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions. J Clin Invest. 1989;84:1086-1095.
6. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
7. Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci U S A. 1981;78:6499-6503.
8. Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis. 1983;3:149-159.