Structure and function of receptors coupled to G proteins

Current Opinion in Cell Biology

Volumn 6, Issue 2, 1994, Pages 180-190

  Baldwin, Joyce M ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE RECEPTOR; RECEPTOR; RHODOPSIN;

CHEMICAL STRUCTURE; COW; HAMSTER; HUMAN; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SEQUENCE ANALYSIS; SWINE;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; CELL MEMBRANE; GTP-BINDING PROTEINS; HUMAN; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CELL SURFACE; RHODOPSIN;

CRICETINAE; SUS SCROFA;

EID: 0028227013     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0955-0674(94)90134-1     Document Type: Article

References (43)

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4. Identification of Amino Acid Residues of Rat Angiotensin II Receptor for Ligand Binding by Site-Directed Mutagenesis
5. Amino-Aromatic Interaction Between Histidine 197 of the Neurokinin-I Receptor and CP 96345
6. Histidine Residues Regulate the Transition of Photoexcited Rhodopsin to Its Active Conformation, Metarhodopsin II
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9. Site-Directed Mutagenesis of the Rat m1 Muscarinic Acetylcholine Receptor. Role of Conserved Cysteines in Receptor Function
10. The Role of Conserved Aspartate and Serine Residues in Ligand Binding and Function of the 5-HT1A Receptor: A Site-Directed Mutation Study
11. Mutation of Asp74 of the Rat Angiotensin II Receptor Confers Changes in Antagonist Affinities and Abolishes G-Protein Coupling
12. + Regulation of Agonist Binding but Does Not Alter Receptor-G Protein Association
13. The Regulation of the Binding Affinity of the Luteinizing Hormone/Choriogonadotropin Receptor by Sodium Ions Is Mediated by a Highly Conserved Aspartate Located in the Second Transmembrane Domain of G Protein-Coupled Receptors
14. [3H]Ketanserin Binding to 5-Hydroxytryptamine-2 Receptors
15. Amino Acid Substitutions at Position 312 in the Seventh Hydrophobic Segment of the β2-Adrenergic Receptor Modify Ligand Binding Specificity
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20. Introduction of Hydroxyl-Bearing Amino Acids Causes Bathochromic Spectral Shifts in Rhodopsin. Amino Acid Substitutions Responsible for Red-Green Color Pigment Spectral Tuning
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22. Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.
23. A Single Amino Acid of the Cholecystokinin-B/Gastrin Receptor Determines Specificity for Non-Peptide Antagonists
24. Molecular Basis for the Species Selectivity of the Substance P Antagonist CP-96345
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26. Characterization of Mutant Rhodopsins Responsible for Autosomal Dominant Retinitis Pigmentosa. Mutations on the Cytoplasmic Surface Affect Transducin Activation
27. Pigmentation Phenotypes of Variant Extension Locus Alleles Result from Point Mutations That Alter MSH Receptor Function
28. Somatic Mutations in the Thyrotropin Receptor Gene Cause Hyperfunctioning Thyroid Adenomas
29. A Constitutively Activating Mutation of the Luteinizing Hormone Receptor in Familial Male Precocious Puberty
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31. Constitutive Activation of the α1b-Adrenergic Receptor by All Amino Acid Substitutions at a Single Site. Evidence for a Region Which Constrains Receptor Activation
32. Constitutively Active Mutants of the α2-Adrenergic Receptor
33. Mutation of Alanine 623 in the Third Cytoplasmic Loop of the Rat Thyrotropin (TSH) Receptor Results in a Loss in the Phosphoinositide but not cAMP Signal Induced by TSH and Receptor Autoantibodies
34. Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.
35. The Extracellular Domain of the Neurokinin-1 Receptor Is Required for High-Affinity Binding of Peptides
36. Delineation of Structural Domains Involved in the Subtype Specificity of Tachykinin Receptors Through Chimeric Formation of Substance P/Subtance K Receptors
37. Structure and Function in Rhodopsin: Replacement by Alanines of the Intradiscal Cysteines 110 and 187, Components of a Conserved Disulphide Bond in Rhodopsin, Affects the Light-Activated Meta II State
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39. Charged Amino Acids Required for Signal Transduction by the m3 Muscarinic Acetylcholine Receptor
40. Substitutions of Different Regions of the Third Cytoplasmic Loop of the Thyrotropin (TSH) Receptor Have Selective Effects on Constitutive, TSH-, and TSH Receptor Autoantibody-Stimulated Phosphoinositide and 3′,5′-Cyclic Adenosine Monophosphate Signal Generation
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42. Palmitoylation of Bovine Opsin and Its Cysteine Mutants in COS Cells
43. Mutations of the α2a Adrenergic Receptor That Eliminate Detectable Palmitoylation Do Not Perturb Receptor G Protein Coupling