Clozapine inhibits serotoninergic transmission by an action at α1-adrenoceptors not at 5-HT1A receptors

European Journal of Pharmacology

Volumn 260, Issue 1, 1994, Pages 79-83

  Lejeune, Françoise ^a   Audinot, Valérie ^a   Gobert, Alain ^a   Rivet, Jean Michel ^a   Spedding, Michael ^a   Millan, Mark J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT1A receptor; Clozapine, 1 Adrenoceptor; Raphe

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 HYDROXYBENZYLHYDRAZINE; 5 HYDROXYTRYPTOPHAN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CIRAZOLINE; CLOZAPINE; PRAZOSIN; SEROTONIN 1A RECEPTOR; SEROTONIN ANTAGONIST; SPIPERONE; TERTATOLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG ANTAGONISM; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; MONOAMINE METABOLISM; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; SEROTONIN METABOLISM; SEROTONINERGIC TRANSMISSION; SUBCUTANEOUS DRUG ADMINISTRATION; TURNOVER TIME;

5-HYDROXYTRYPTOPHAN; ANIMAL; BRAIN CHEMISTRY; CLOZAPINE; ELECTROPHYSIOLOGY; MALE; NEURONS; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, PURINERGIC P1; RECEPTORS, SEROTONIN; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 0028226145     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(94)90012-4     Document Type: Article

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