The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects

Regulatory Peptides

Volumn 51, Issue 1, 1994, Pages 63-74

  Elahi, Dariush ^a   McAloon Dyke, Marianne ^a   Fukagawa, Naomi K ^a   Meneilly, Graydon S ^b   Sclater, Anne L ^a   Minaker, Kenneth L ^a   Habener, Joel F ^c   Andersen, Dana K ^d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Diabetes; GIP; GLP 1(7 37); Hepatic glucose production; Incretin; Insulinotropic

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1 [7-37]; GLUCOSE; INSULIN; PEPTIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DRUG SYNERGISM; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDES; HUMANS; INJECTIONS, INTRAVENOUS; INSULIN; MALE; PEPTIDE FRAGMENTS; PEPTIDES;

EID: 0028224617     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-0115(94)90136-8     Document Type: Article

References (30)

1. Enteroinsular axis
2. A gastric inhibitory polypeptide. I. The amino acid composition and the tryptic peptides
3. The incretin concept today
4. Hamster pre-proglucagon contains the sequence of glucagon and two related peptides
5. Molecular forms of glucagon-like peptides in man
6. Glucagonostatic and insulinotropic action of glucagonlike peptide I-(7–36)-amide
7. Insulinotropin: glucagon-like peptide I (7–37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
8. Glucagonlike peptide I (7–37) actions on endocrine pancreas
9. Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the pro-hormone sequence
10. GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN
11. Preserved incretin activity of glucagon-like peptide 1 [7–36] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
12. Future Meetings
13. Effects of arterial versus venous sampling on analysis of glucose kinetics in man
14. Influences of glucose loading and injected insulin on hepatic glucose output
15. Pancreatic alpha- and beta-cell responses to GIP infusion in normal man
16. Oral glucose augmentation of insulin secretion: interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels
17. Feedback inhibition of insulin secretion in man: relationship to the hyperinsulinemia of obesity
18. Determination of blood sugar
19. Methods of Hormone Radioimmunoassay
20. Immunoassay of insulin: two antibody system. Plasma insulin in normal sub-diabetes and diabetic rats
21. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-transcriptional processing
22. Radioimmunoassay for gastric inhibitory polypeptide
23. Insulin control of glucose metabolism in man: a new kinetic analysis
24. The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus
25. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7–36) amide infused at near physiological insulinotropic hormone and glucose concentrations
26. Antidiabetogenic effect of glucagon-like peptide-1 (7–36)amide in normal subjects and patients with diabetes mellitus
27. Insulinotropic action of glucagonlike peptide-1-(7–37) in diabetic and nondiabetic subjects
28. Comparative studies on the insulinotropic and somatostatinotropic activities of GLP-1 (7–36) and GIP in the isolated perfused rat pancreas and stomach
29. Biological effects and metabolic rates of glucagonlike peptide-1 7–36 amide and glucagonlike peptide-1 7–37 in healthy subjects are indistin-guishable
30. Author Index