Toxic equivalency factors for dioxin-like PCBs. Report on WHO-ECEH and IPCS consultation, December 1993

Chemosphere

Volumn 28, Issue 6, 1994, Pages 1049-1067

  Ahlborg, UG ^a   Becking, GC ^b   Birnbaum, LS ^c   Brouwer, A ^d   Derks, HJGM ^e   Feeley, M ^f   Golor, G ^g   Hanberg, A ^a   Larsen, JC ^h   Liem, AKD ^e   Safe, SH ⁱ   Schlatter, C ^j   Waern, F ^a   Younes, M ^k   Yrjänheikki, E ^l  

^a KAROLINSKA INSTITUTE   (Sweden)

^b IPCS IRRU ^*  (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^f HEALTH CANADA   (Canada)

^g FREIE UNIVERSITÄT BERLIN   (Germany)

^h National Food Agency of Denmark   (Denmark)

ⁱ TEXAS A AND M UNIVERSITY   (United States)

^j Institute of Toxicology Schwerzenbach   (Switzerland)

^k WHO European Centre for Environment and Health   (Netherlands)

^l Occupational Safety and Health Division ^*  (Finland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; DIOXIN; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN;

BODY BURDEN; DATA BASE; ECOTOXICOLOGY; EUROPE; INTERNATIONAL COOPERATION; NETHERLANDS; POLLUTANT; REVIEW; SAFETY; TOXICITY; WORLD HEALTH ORGANIZATION;

EID: 0028224204     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/0045-6535(94)90324-7     Document Type: Article

References (78)

1. Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept
2. Toxicity equivalency factors for PCBs?
3. Multistage hepatocarcinogenesis in the rat: Insights into risk estimation
4. Review of dioxins
5. International toxicity equivalency factor (I-TEF) method of risk assessment for complex mixtures of dioxins and related compounds
6. Trend studies of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in human milk
7. Scientific Criteria Document for standard development
8. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors
9. Polychlorinated biphenyls (PCBs) environmental impact biochemical and toxic responses and implications for risk assessment
10. Interim procedures for estimating risks associated with exposure to mixtures of chlorinated dibenzo-p-dioxins and -dibenzofurans and 1989 update
11. Assessment of the toxicity of mixtures of halogenated dibenzo-p-dioxins and dibenzofurans by use of toxicity equivalency factors (TEF)
12. Ah receptor-mediated luciferase expression: a tool for monitoring dioxin-like toxicity
13. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius of chick embryos in ovo and in mouse thymus analgen in vitro
14. Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor
15. Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/6N mice
16. Assessment of the EROD inducing potency of eleven 2,3,7,8-substituted PCDD/Fs and three coplanar PCBs in the chick embryo
17. Non-ortho- and mono-ortho-chlorine-substituted polychlorinated biphenyls - embryotoxicity and inhibition of lymphoid development
18. Polychlorinated biphenyls, classified as either phenobarbitalor 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats
19. Effects of polychlorinated biphenyls in rat liver: Correlation between primary subcellular effects and promoting activity
20. Polychlorinated and polybrominated biphenyl congeners and retinoid levels in rat tissues: Structure-activity relationships
21. Subchronic toxicity of 3,3',4,4',5-pentachlorobiphenyl in the rat. Part I - clinical, biochemical and histopathological changes
22. Immunotoxicity of the halogenated aromatic hydrocarbons - QSARs and interactive effects
23. Comparative ability of various PCBs PCDFs and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment
24. Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) rat hepatic receptor levels by polychlorinated biphenyls: Structure-activity relationships
25. In vitro bioassay for dioxinlike activity based on alterations in epithelial cell proliferation and morphology
26. Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basic of induction of cytochrome P-450 or P-448
27. Swedish Dioxin Survey: Evaluation of the H-4-II E bioassay for screening environmental samples for dioxin-like enzyme induction
28. Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice
29. Tumour promotion related effects induced by halogenated compounds; studies in vitro and in vivo
30. Relative tumour promoting activity of three polychlorinated biphenyls in rat liver
31. Nonadditive interactions of mixtures of 2,3,7,8-TCDD and 3,3',4,4'-tetrachlorobiphenyl on aryl hydrocarbon hydroxylase induction in rainbow trout (Oncorhynchus mykiss)
32. A rapid and sensitive cell culture bioassay for measuring ethoxyresorufin-O-deethylase (EROD) activity in cultured hepatocytes exposed to halogenated aromatic hydrocarbons extracted from wild bird eggs
33. Modulation of rat hepatic microsomal testosterone hydroxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers
34. Induction of aryl hydrocarbon hydroxylase AHH by two previously uncharacterized pentachlorinated biphenyls in a mouse and a rat hepatoma cell line
35. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: Quantitative structure-activity relationships
36. Polychlorinated biphenyls: Correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs)
37. Teratogenic evaluation of the symmetrical isomers of hexachlorobiphenyl (HCB) in the mouse
38. Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. I. Teratogenicity of 3,3',4,4',5,5'-hexachlorobiphenyl
39. Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. II. Comparison of 4,4'-dichlorobiphenyl, 3,3',4,4'-tetrachlorobiphenyl, 3,3',5,5'-tetrachlorobiphenyl, and 3,3',4,4'-tetramethylbiphenyl
40. Teratogenicity and immunotoxicity of 3,3'4,4',5-pentachlorobiphenyl in C57BL/6 mice
41. Limited PCB antagonism of TCDD-induced malformations in mice
42. Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3',4,4',5,5'-hexachlorobiphenyl (HxCB) enhance anti-CD3-induced T cell activation
43. Effects of TCDD and its congeners 3,3',4,4'-tetrachloroazoxybenzene and 3,3',4,4'-tetrachlorobiphenyl on lymphoid development in the thymus of avian embryos
44. Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer
45. Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity
46. Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules
47. Hepatic microsomal enzyme induction by 2,2',3,3',4,4'- and 2,2',3',4,4',5-hexachlorobiphenyl
48. Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Effects of di-ortho substitution
49. Immunochemical quantitation of cytochrome P-450 isoenzymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats
50. Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure-activity relationship
51. PCBs and PBBs: Biologic and toxic effects on C57BL/6J and DBA/2J inbred mice
52. Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture
53. Study of the separate and combined effects of the non-planar 2,5,2',5'- and the planar 3,4,3',4'-tetrachlorobiphenyl in liver and lymphocytes in vivo
54. PCB isomers and congeners: Induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells
55. Polychlorinated biphenyl immunotoxicity: Dependence on isomer planarity and the Ah gene complex
56. Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice
57. Effects of acute and subchronic oral dosing on immune function and EROD induction in C57BL/6 female mice: Assessment of TEF values
58. Toxicity and biochemical potencies of polychlorinated biphenyl congeners relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin in three months feeding studies in the rat
59. Apparent antagonistic effects between 3,3',4,4',5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic retinoid loss in the rat: Possible involvement of CYP1A2
60. Apparent antagonistic effects between 2,3,3',4,4',5-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on CYP1A1 and CYP1A2 activities: Possible role of metabolism and target tissue concentration
61. Subchronic effects of 2,3,3',4,4',5-hexachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone and retinoid metabolism: Possible role of cytochrome P450 and UDP-glucuronyltransferases
62. Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss)
63. Utilization of cultured chick embryo hepatocytes as in vitro bioassay for polychlorinated biphenyls (PCBs): Quantitative structure-induction relationships
64. Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats