Increased Rate of Spontaneous Mitotic Recombination in T Lymphocytes from a Bloom's Syndrome Patient Using a Flow‐cytometric Assay at HLA‐A Locus

Japanese Journal of Cancer Research

Volumn 85, Issue 6, 1994, Pages 610-618

  Kusunoki, Yoichiro ^a   Hayashi, Tomonori ^a   Hirai, Yuko ^a   Kushiro, Jun‐ichi ^a   Tatsumi, Kouichi ^b   Kurihara, Takayuki ^b,c   Zghal, Mohamed ^d   Kamoun, Mohamed R ^d   Takebe, Hiraku ^b   Jeffreys, Alec ^e   Nakamura, Nori ^a   Akiyama, Mitoshi ^a  

^a RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d CHARLES NICOLLE HOSPITAL   (Tunisia)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Bloom's syndrome; HLA A locus; Mitotic recombination; Somatic mutation; Spontaneous mutation rate

Indexed keywords

HLA A ANTIGEN;

ADULT; ALLELE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BLOOM SYNDROME; CASE REPORT; CELL CULTURE; CHROMATID EXCHANGE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE LOCUS; GENETIC RECOMBINATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; MALE; MITOSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; SOMATIC CELL; T LYMPHOCYTE;

ADULT; ALLELES; BLOOM SYNDROME; CELL CYCLE; CELLS, CULTURED; CHROMOSOMES, HUMAN; FEMALE; FLOW CYTOMETRY; HLA-A ANTIGENS; HLA-DQ ANTIGENS; HUMAN; MALE; MIDDLE AGE; MITOSIS; MUTATION; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; SISTER CHROMATID EXCHANGE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; T-LYMPHOCYTES;

EID: 0028223554     PISSN: 09105050     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1994.tb02403.x     Document Type: Article

References (41)

1. Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs
2. Bloom's syndrome: X. The cancer proneness points to chromosome mutation as a crucial event in human neoplasia
3. Cytogenetic evidence for crossing‐over in vitro in human lymphoid cells
4. Chromosomal breakage in a rare and probably genetically determined syndrome of man
5. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes
6. Altered DNA ligase I activity in Bloom's syndrome cells
7. DNA ligase I deficiency in Bloom's syndrome
8. Structural alterations of DNA ligase I in Bloom syndrome
9. 5‐Bromodeoxyuridine‐dependent increase in sister‐chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity
10. Immunological lesions in human uracil DNA glycosylase: association with Bloom syndrome
11. Different mutations responsible for the elevated sister‐chromatid exchange frequencies in Bloom syndrome and X‐irradiated B‐lymphoblastoid cell lines originating from acute leukemia
12. Elevated superoxide dismutase in Bloom's syndrome: a genetic condition of oxidative stress
13. Elevated sister chromatid exchange phenotype of Bloom syndrome cells is complemented by human chromosome 15
14. Diphtheria toxin resistance in human fibroblast cell strains from normal and cancerprone individuals
15. Elevated spontaneous mutation rate in Bloom's syndrome fibroblasts
16. Bloom's syndrome: evidence for an increased mutation frequency in vivo
17. Frequency of variant erythrocytes at the glycophorin A locus in two Bloom's syndrome patients
18. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome
19. Development of a flow‐cytometric HLA‐A locus mutation assay for human peripheral blood lymphocytes
20. − T cells bearing T‐cell receptor α and β chains in two normal men
21. Sister‐chromatid exchanges induced by ultraviolet light in Bloom's syndrome fibroblasts
22. Isolation of HLA locus‐specific DNA probes from the 3′‐untranslated region
23. Organization of the human class I major histocompatibility complex genes
24. A novel human DNA polymorphism resulting from transfer of DNA from chromosome 6 to chromosome 16
25. Systematic cloning of human minisatellites from ordered array chromid libraries
26. Human T cell‐specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains
27. Genetic analysis of amplified DNA with immobilized sequence‐specific oligonucleotide probes
28. A simple and rapid method for HLA‐DQA1 genotyping by polymerase chain reaction‐single strand conformation polymorphism and restriction enzyme cleavage analysis
29. The statistical theory of bacterial populations subject to mutation
30. Mutation of bacteria from virus sensitivity to virus resistance
31. Report of the committee on the genetic constitution of chromosome 6
32. Gene maps and location data bases
33. Report of the committee on the genetic constitution of chromosomes 5 and 6
34. Bloom's syndrome: III. Analysis of the chromosome aberration characteristic of this disorder
35. In vivo human somatic mutation: frequency and spectrum with age
36. Molecular nature of in vivo mutations in human cells at the autosomal HLA‐A locus
37. + T cells
38. Bloom's syndrome‐: XVIII. Hypermutability at a tandem‐repeat locus
39. Dads and disomy and disease
40. Sister‐chromatid exchange in childhood in relation to age and sex
41. Frequencies of sister‐chromatic exchanges in relation to cell kinetics in lymphocyte cultures