Evidence that s-adenosylmethionine and n-acetylcysteine reduce injury from sequential cold and warm ischemia in the isolated perfused rat liver

Transplantation

Volumn 57, Issue 8, 1994, Pages 1161-1168

  Dunne, J Bruce ^a   Davenport, Mark ^a   Williams, Roger ^a   Tredger, J Michael ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ASPARTATE AMINOTRANSFERASE; PURINE NUCLEOSIDE PHOSPHORYLASE; S ADENOSYLMETHIONINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CONTROLLED STUDY; GLYCOLYSIS; ISOLATED LIVER; LIVER BLOOD FLOW; LIVER INJURY; LIVER ISCHEMIA; LIVER PROTECTION; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SUBCUTANEOUS DRUG ADMINISTRATION; TEMPERATURE;

ACETYLCYSTEINE; ANIMAL; ASPARTATE AMINOTRANSFERASES; BILE; COLD; HEAT; ISCHEMIA; LIVER; MALE; OXYGEN; OXYGEN CONSUMPTION; RATS; RATS, INBRED LEW; REGIONAL BLOOD FLOW; REPERFUSION INJURY; S-ADENOSYLMETHIONINE; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0028223328     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199404270-00004     Document Type: Article

References (50)

1. Otto G, Woll H, David H. Preservation damage in liver trans plantation: electron microscopic findings. Transplant Proc 1984; 16: 1247.
2. McKeown CMB, Edwards V, Phillips MJ, Harvey PRC, Petrunka CN, Strasberg SM. Sinusoidal lining cell damage: the critical injury in cold preservation of liver allografts in the rat. Transplantation 1988; 46: 178.
3. Momii S, Koga A. Time-related morphological changes in cold-stored rat livers: a comparison of Euro-Collins solution with UW solution. Transplantation 1990; 50: 745.
4. Caldwell-Kenkel JC, Thurman RG, Lemasters JJ. Selective loss of nonparenchymal cell viability after cold ischemic storage of rat livers. Transplantation 1988; 45: 834.
5. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology 1989; 10: 292.
6. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 1991; 13: 83.
7. Ikeda T, Yanaga K, Kishikawa K, Kakizoe S, Shimada M, Sugimachi K. Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats. Hepatology 1992; 16: 454.
8. Nishida T, Koseki M, Kamiike W, et al. Levels of purine com pounds in the perfusate as a biochemical marker of ischemic injury of cold-preserved liver. Transplantation 1987; 44: 16.
9. Harvey PRC, Iu S, McKeown CMB, Strasberg SM. Adenine nucleotide tissue concentrations and liver allograft viability after cold preservation and warm ischemia. Transplantation 1988; 45: 1016.
10. Kamiike W, Burdelski M, Steinhoff G, Ringe B, Lauchart W, Pichlmayer R. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation 1988; 45: 138.
11. Kim S-K, Belzer FO, Southard JH. Loss of mitochondrial respi ratory function and its suppression during cold ischaemic preservation of rat livers with UW solution. Hepatology 1992; 16: 742.
12. Woods HF, Krebs HA. Lactate production in the perfused rat liver. Biochem J 1971; 125: 129.
13. Furukawa H, Todo S, Imventarza O, et al. Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with UW solution. Transplantation 1991; 51: 1000.
14. Howard TK, Goran B, Klintmalm G, et al. The influence of pres ervation injury on rejection in the hepatic transplant recipient. Transplantation 1990; 49: 103.
15. Adam R, Bismuth H, Diamond T, et al. Effect of extended cold ischaemia with UW solution on graft function after liver transplantation. Lancet 1992; 340: 1373.
16. Clavien P-A, Harvey PRC, Strasberg SM. Preservation and re perfusion injuries in liver allografts: an overview and synthesis of current studies. Transplantation 1992; 53: 957.
17. Friedel HA, Goa KL, Benfield P. s-Adenosyl-L-methionine: A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989; 38: 389.
18. Montero C, Smolenski RT, Duley JA, Simmonds HA. s-Adenos-ylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase. Biochem Pharmacol 1990; 40: 2617.
19. Chawla RK, Bonkovsky HL, Galambos JT. Biochemistry and pharmacology of s-adenosyl-L-methionine and rationale for its use in liver disease. Drugs 1990; 40 (suppl 3): 98.
20. Bray GP, Tredger JM, Williams R. s-Adenosylmethionine pro tects against acetaminophen hepatotoxicity in two mouse models. Hepatology 1992; 15: 297.
21. Ponsoda X, Jover R, Gomez-Lechon MJ, Fabra R, Trullenque R, Castell JV. Intracellular glutathione in human hepatocytes incubated with s-adenosyl-L-methionine and GSH-depleting drugs. Toxicology 1991; 70: 293.
22. Kakimoto H, Kawata S, Imai Y, Inada M, Matsuzawa Y, Tarui S. Changes in lipid composition of erythrocyte membranes with administration of s-adenosyl-L-methionine in chronic liver disease. Gastroenterol Jpn 1992; 27: 508.
23. Harrison PM, Wendon JA, Gimson AES, Alexander GJM, Williams R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991; 324: 1852.
24. Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet 1991; 20: 123.
25. Kamada N, Caine RY. A surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983; 93: 64.
26. Riedel GL, Scholle JL, Shepherd AP, Ward WF. Effects of he matocrit on oxygenation of the isolated perfused rat liver. Am J Physiol 1983; 245: G769.
27. Rao PN, Walsh TR, Makowka L, et al. Purine nucleoside phos-phorylase: a new marker for free oxygen radical injury to the endothelial cell. Hepatology 1990; 11: 193.
28. Martin DW. The chemistry of respiration. In: Martin DW, Mayes PA, Rodwell VW, eds. Harper's review of biochemistry. Los Altos: Lange, 1983: 535.
29. Chazouilleres O, Ballet F, Chretien Y, et al. Protective effect of two vasodilators on liver function after long hypothermic preservation: a study in the isolated perfused rat liver. Hepatology 1989; 8: 1281.
30. Takei Y, Gao W, Hijioka T, et al. Increase in survival of liver grafts after rinsing with warm Ringer's solution due to improvement of hepatic microcirculation. Transplantation 1991; 52: 225.
31. Tavolini N, Reed JS, Boyer JL. Hemodynamic effects on deter minants of bile secretion in isolated rat liver. Am J Physiol 1978; 234: E584.
32. Konno H, Lowe PJ, Hardison WG, Miyai K, Nakamura S, Baba S. Breakdown of hepatic tight junctions during reoxygenation injury. Transplantation 1992; 53: 1211.
33. Iu S, Harvey PRC, Makowka L, Petrunka CN, Ilson RG, Strasberg SM. Markers of allograft viability in the rat. Transplantation 1987; 44: 562.
34. Bachmann S, Olesky I, Thurman RG, Lemasters JJ. Improved graft survival using warm Carolina rinse solution after orthotopic rat liver transplantation. Gastroenterology 1991; 100: A818.
35. Gao W, Takei Y, Marzi I, et al. Carolina rinse solution: a new strategy to increase survival time after orthotopic liver transplantation in the rat. Transplantation 1991; 52: 417.
36. Stramentinoli G, Catto E. Pharmacokinetic studies of S-adenos-yl-L-methionine (SAMe) in several animal species. Pharmacol Res Commun 1976; 8: 211.
37. Giulidori P, Cortellaro M, Moreo G, Stramentinoli G. Pharma cokinetics of s-adenosyl-L-methionine in healthy volunteers. Eur J Clin Pharmacol 1984; 27: 119.
38. Pearson JD, Gordon JL. Nucleotide metabolism by endothelium. Annu Rev Physiol 1985; 47: 617.
39. Burnstock G. Local purinergic regulation of blood pressure. In: Vanhoutte PM, ed. Vasodilation: vascular smooth muscle, peptides, autonomic nerves and endothelium. New York: Raven, 1988: 1.
40. Lieberman GE, Lewis GP, Peters TJ. A membrane-bound en zyme in rabbit aorta capable of inhibiting adenosine diphosphate induced platelet aggregation. Lancet 1977; 2: 330.
41. Thom H, Bortolini M, Galli-Kienle M. Anti-ischaemic activ ity of S-adenosyl-L-methionine (SAMe) during hypoxia/ reoxygenation in the isolated perfused rat liver. Drug Invest 1992; 4 (suppl 4): 64.
42. Imai Y, Scoble J, Owen JS. Increased Na-dependent D-glucose transport and altered lipid composition in renal cortical brush-border membrane vesicles from bile-duct ligated rats. J Lipid Res 1992; 33: 473.
43. Owen JS, Rafique S, Osman E, Burroughs AK. Ability of s-adenosyl-L-methionine to ameliorate lipoprotein-induced membrane lipid abnormalities and cellular dysfunction in human liver disease. Drug Invest 1992; 4 (suppl 4): 22.
44. Mochida S, Arai M, Ohno A, Masaki N, Ogata I, Fujiwara K. The oxidative stress of hepatocytes and the activation state of Kupffer cells differ after reperfusion between warm and cold ischemia. Hepatology 1992; 16: 53A.
45. Lemasters JJ, Thurman RG. Hypoxic, ischaemic and preserva tion-induced injury in the liver. In: Ballet F, Thurman RG eds. Perfused liver: clinical and basic applications. London: Libbey, 1991: 97.
46. Corrales F, Alvarez L, Pajares MA, Ortiz P, Mato JM. Impair ment of methionine metabolism in liver disease. Drug Invest 1992; 4 (suppl 4): 8.
47. Finkelstein JD, Kyle WE, Martin JJ, Pick AM. Activation of cystathione synthase by adenosylmethionine and adenosyle-thionine. Biochem Res Commun 1975; 66: 81.
48. Jaeschke H, Smith CV, Mitchell JR. Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver. J Clin Invest 1988; 81: 1240.
49. Vivot C, Stump DD, Schwartz ME, Theise ND, Miller CM. N-Acetylcysteine attenuates cold ischaemia/reperfusion injury in the isolated perfused rat liver. Transplant Proc 1993; 25: 1983.
50. Burgunder JM, Varriale A, Lauterberg BH. Effect of N-acetyl-cysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol 1989; 36: 127.