Kinetic and mutational analysis of human immunodeficiency virus type 1 reverse transcriptase inhibition by inophyllums, a novel class of non- nucleoside inhibitors

Journal of Biological Chemistry

Volumn 269, Issue 9, 1994, Pages 6325-6331

  Taylor, P B ^a   Culp, J S ^a   Debouck, C ^a   Johnson, R K ^a   Patil, A D ^a   Woolf, D J ^a   Brooks, I ^a   Hertzberg, R P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

9 CHLORO 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; INOPHYLLUM B; INOPHYLLUM C; INOPHYLLUM P; PLANT EXTRACT; RNA DIRECTED DNA POLYMERASE INHIBITOR; TIBO R 82913; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; BASE SEQUENCE; BENZODIAZEPINES; COMPARATIVE STUDY; COUMARINS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; IMIDAZOLES; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUPPORT, U.S. GOV'T, P.H.S.;

AVES; AVIAN MYELOBLASTOSIS VIRUS; CALOPHYLLUM INOPHYLLUM; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE;

EID: 0028221241     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)