Cross-Reactivity between Autoimmune Anti-Ul snRNP Antibodies and Neutralizing Epitopes of HIV-1 gp 120/41

AIDS Research and Human Retroviruses

Volumn 10, Issue 3, 1994, Pages 253-262

  Douvas, Angeline ^a   Takehana, Yoshi ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; IMMUNOGLOBULIN G; RIBONUCLEOPROTEIN ANTIBODY; SMALL NUCLEAR RNA;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED CONNECTIVE TISSUE DISEASE; PRIORITY JOURNAL; RNA SPLICING; SEQUENCE HOMOLOGY; SERUM;

AMINO ACID SEQUENCE; AUTOANTIBODIES; BLOTTING, WESTERN; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMAN; MIXED CONNECTIVE TISSUE DISEASE; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0028220432     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.1994.10.253     Document Type: Article

References (64)

1. Takahashi, H, Germain, RN, Moss, B, and Berzofsky, JA: An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class Il-restricted help for itself. J Exp Med 1990; 171: 571-576.
2. Nixon, DF and McMichael, AJ: Cytotoxic T-cell recognition of HIV proteins and peptides. AIDS 1991; 5: 1049-1059.
3. Harris, SJ, Gearing, AJH, Layton, GT, Adams, SE, and Kingsman, AJ: Enhanced proliferative cellular responses to HIV-1 V3 peptide and gpl20 following immunization with V3:Ty virus particles. Immunology 1992; 77: 315-321.
4. Moore, RL and Fox, BS: Immunization of mice with human immunodeficiency virus glycoprotein gpl60 peptide 315-329 induces both class I- and class Il-restricted T cells: Not all T cells can respond to whole molecule stimulation. AIDS Res Hum Retroviruses 1993; 9: 51-59.
5. Rusche, JR, Javaherian, K, McDanal, C, Petro, J, Lyn, DL, Grimaila, R, Langlois, A, Gallo, RC, Arthur, LO, Fischinger, PJ, Bolognesi, DP, Putney, SD, and Matthews, TJ: Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gpl 20. Proc Nati Acad Sci USA 1988; 85: 3198-3202.
6. Durda, PJ, Bachaler, L, Clapham, P, Jenoski, AM, Leece, B, Matthews, TJ, McKnight, A, Pomerantz, R, Rayner, M, and Weinhold, KJ: HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide. AIDS Res Hum Retroviruses 1990; 6: 1115-1123.
7. Broliden, PA, von Gegerfelt, A, Clapham, P, Rosen, J, Fenya, EM, Wahren, B, and Broliden, K: Identification of human neutralizationinducing regions of the human immunodeficiency virus type 1 envelope glycoproteins. Proc Nati Acad Sci USA 1992; 89: 461-465.
8. Javaherian, K, Langois, A, McDanal, C, McDanal, C, Ross, KL, Eckler, LI, Jellis, CL, Profy, AT, Rusche, JR, Bolognesi, DP, Putney, SD, and Matthews, TH: Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. Proc Nati Acad Sci USA 1989; 86: 6768-6772.
9. Laman, JD, Schellekens, MM, Abacioglu, YH, Lewis, GK, Tersmette, M, Fouchier, RAM, Langedijk, JPM, Classen, E, and Boersma, WJA: Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gpl20 third variable domain. Virology 1992; 66: 1823-1831.
10. Kenealy, WR, Matthews, TJ, Ganfield, MC, Langlois, AJ, Waselefsky, DM, and Petteway SR Jr: Antibodies from human immunodeficiency virus-infected individuals bind to a short amino acid sequence that elicits neutralizing antibodies in animals. AIDS Res Hum Retroviruses 1989; 5: 173-182.
11. Girard, M, Kieny, MP, Pinter, A, Barre-Sinoussi, F, Nara, P, Kolbe, H, Kusumi, K, Chaput, A, Reinhart, T, Muchmore, E, Ronco, J, Kaczorek, M, Gomard, E, Gluckman, JC, and Fultz, PN: Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus. Proc Nati Acad Sci USA 1991; 88: 542-546.
12. Akerblom, L, Hinkula, J, Broliden, PA, Makitalo, B, Fridberg, T, Rosen, J, Villacres-Eriksson, M, Morein, B, and Wahren, B: Neutralizing cross-reactive and non-neutralizing monoclonal antibodies to HIV-1 gpl20. AIDS 1990; 4: 953-960.
13. Clements, GJ, Price-Jones, MJ, Stephens, PE, Sutton, C, Schulz, TF, Claapham, PR, McKeating, JA, McCIure, MO, Thomson, S, Marsh, M, Kay, J, Weiss, RA, and Moore, JP: The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: A possible function in viral fusion? AIDS Res Hum Retroviruses 1991; 7: 3-16.
14. Murakami, T, Hattori, T, and Takatsuki, K: A principal neutralizing domain of human immunodeficiency virus type 1 interacts with proteinase-like molecule(s) at the surface of Molt-4 clone 8 cells. Biochim Biophys Acta 1991; 1079: 279-284.
15. Werner, A and Levy, JA: Human immunodeficiency virus type 1 envelope gpl20 is cleaved after incubation with recombinant soluble CD4. J Virol 1993; 67: 2566-2574.
16. Harvima, IT, Jarvima, RJ, Nilsson, G, Ivanoff, L, and Schwartz, LB: Separation and partial characterization of proteinases with substrate specificity for basic amino acids from human MOLT-4 T lymphocytes: Identification of those inhibited by variable loop-V3 peptides of HIV-1 (human immunodeficiency virus-1) envelope glycoprotein. Biochem J 1993; 292: 711-718.
17. Schrier, RD, Grann, JW Jr, Langois, AJ, Shriver, K, Nelson, JA, and Oldstone, MBA: B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus. J Virol 1988; 62: 2531-2536.
18. Dalgleish, AG, Chanh, TC, Kennedy, RC, Kanda, P, Clapham, PR, and Weiss, RA: Neutralization of diverse HIV-1 strains by monoclonal antibodies raised against a gp41 synthetic peptide. Virology 1988; 165: 209-215.
19. Vanini, S, Longhi, R, Lazzarin, A, Vigo, E, Sicardi, AG, and Viale, G: Discrete regions of HIV-1 gp41 defined by syncytia-inhibiting affinity-purified human antibodies. AIDS 1993; 7: 167-174.
20. Kelley, WN, Harris, ED, Ruddy, S, and Sledge, CB: Textbook of Rheumatology. Saunders, Philadelphia, 1989.
21. Jiang, S, Lin, K, Strick, N, and Neurath, AR: HIV-1 inhibition by a peptide. Nature (London) 1993; 365: 113.
22. Surowy, CS, van Santen, VL, Scheib-Wixted, SM, and Spritz, RA: Direct, sequence-specific binding of the human U1-60K ribonucleoprotein antigen protein to loop I of Ul small nuclear RNA. Mol Cell Biol 1989; 9: 4179-4186.
23. Douvas, A and Sobelman, S: Multiple overlapping homologies between viral and nuclear antigens. Proc Nati Acad Sci USA 1991; 88: 6328-6332.
24. Cram, DS, Fisicaro, N, Coppel, RL, Whittingham, S, and Harrison, LC: Mapping of multiple B cell epitopes on the 70-kilodalton autoantigen of the Ul ribonucleoprotein complex. I Immunol 1990; 145: 630-635.
25. Query, CC and Keene, JD: A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with a retroviral p30gag antigen. Cell 1987; 51: 211-220.
26. Takeda, A, Tuazon, CU, and Ennis, FA: Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science 1988; 242: 580-583.
27. Linett, GP, Hartzmann, RJ, Ledbetter, JA, and June, CH: HIV-1-infected T cells show a selective signaling defect after perturbation of CD3/antigen receptor. Science 1988; 241: 573-576.
28. Golding, H, Shearer, GM, Hillman, K, Lucas, P, Manischewitz, J, Zajac, RA, Clerici, M, Gress, RE, Boswell, RN, and Golding, B: Common epitope in human immunodeficiency virus (HIV) l-gp41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune disfunction in HIV 1-infected individuals. J Clin Invest 1989; 83: 1430-1435.
29. Pantaleo, G, Graziosi, C, and Fauci, A: Immunopathogenesis of human immunodeficiency virus infection. New Engl J Med 1993; 328: 327-335.
30. Golding, H, Robey, HFA, Gater, FT III, Linder, W, Beining, PR, Hoffman, T, and Golding, B: Identification of homologous regions in human immunodeficiency virus I gp41 and human class II beta I domain. J Exp Med 1988; 167: 914-923.
31. Takahashi, H, Cohen, J, Hosmalin, A, Cease, KB, Houghten, R, Cometto, JL, Delisi, C, Moss, B, Germain, RN, and Berzofsky, JA: An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gpl60 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc Nati Acad Sci USA 1988; 85: 3105-3109.
32. Douvas, A, Stumph, WE, Lopez, RR, and Tan, EM: Isolation and characterization of nuclear ribonucleoprotein complexes using human antinuclear ribonucleoprotein antibodies. J Biol Chem 1979; 254: 3608-3614.
33. Douvas, A: Antibodies occurring in two different rheumatic disease react with the same nuclear ribonucleoprotein particle. Proc Nati Acad Sci USA 1982; 79: 5401-5405.
34. Crow, MK, Kushner, B, Jover, JA, Friedman, SM, Mechanic, SE, and Stohl, W: Human peripheral blood T helper cell-induced B cell activation results in B cell surface expression of the CD23 (BLAST-2) antigen. Cell Immunol 1989; 121: 99-112.
35. Towbin, A, Staehelin, T, and Gordon, J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Nati Acad Sci USA 1979; 76: 4350-4354.
36. Habeshaw, JA, Dalgleish, AG, Bountiff, L, Newell, AL, Wilks, D, Walker, LC, and Manca, F: AIDS pathogenesis: HIV envelope and its interaction with cell proteins. Immunol Today 1990; 11: 418-425.
37. D'Souza, MP, Durda, P, Hanson, CV, Milman, G, and collaborating investigators: Evaluation of monoclonal antibodies to HIV-1 by neutralization and serologic assays: An international collaboration. AIDS 1991; 5: 1061-1070.
38. Theissen, H, Etzerodt, M, Reuter, R, Schneider, C, Lottspeich, F, Argos, P, Luhrmann, R, and Philipson, L: Cloning of the human cDNA for the Ul RNA-associated 70K protein. EMBO J 1986; 5: 3209-3217.
39. Query, CC, Bentley, RC, and Keene, JD: A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K Ul snRNP protein. Cell 1989; 57: 89-101.
40. Netter, HJ, Guldner, HH, Szostecki, C, and Will, H: Major autoantigenic sites of the (Ul) small nuclear ribonucleoprotein-specific 68-kDa protein. Scand J Immunol 1990; 32: 163-176.
41. Query, CC, Bentley, RC, and Keene, JD: A specific 31-nucleotide domain of Ul RNA directly interacts with the 70K small nuclear ribonucleoprotein component. Mol Cell Biol 1989; 9: 4872-4881.
42. Krainer, AR, Mayeda, A, Kozak, D, and Binn, G: Functional expression of cloned human splicing factor SF2: Homology to RNAbinding proteins, U1 70K, and Drosophila splicing regulators. Cell 1991; 66: 383-394.
43. Bandziulis, RJ, Swanson, MS, and Dreyfuss, G: RNA-binding proteins as developmental regulators. Genes Dev 1989; 3: 431-437.
44. Pincus, SH, Messer, KG, Schwartz, DH, Lewis, GK, Graham, BS, Blattner, WA, and Fisher, G: Differences in the antibody responses to human immunodeficiency virus-1 envelope glycoprotein (gp 120) in infected laboratory workers and vaccines. J Clin Invest 1993; 91: 1987-1996.
45. Gorny, MK, Xu, JY, Gianakakos, V, Karwowska, S, Williams, C, Sheppard, HW, Hanson, CV, and Zolla-Pazner, S: Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoprotein. Proc Nati Acad Sci USA 1991; 88: 3238-3242.
46. Gomy, NK, Xu, JY, Karwowska, S, Buchbinder, A, and Zolla-Pazner, S: Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gpl20. J Immunol 1993; 150: 635-643.
47. Tilley, SA, Honnen, WJ, Racho, ME, Chou, TC, and Pinter, A: Synergistic neutralization of HIV-1 by human monoclonal antibodies against the V3 loop and the CD4-binding site of gpl20. AIDS Res Hum Retroviruses 1992; 8: 461-467.
48. Pinter, A, Honnen, WJ, and Tilley, SA: Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gpl20 associated with Env processing and with binding of ligands to these sites. J Virol 1993; 67: 5692-5697.
49. Moore, JP and Ho, DD: Antibodies to discontinuous or conformationally sensitive epitopes on the gpl20 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humans. J Virol 1993; 67: 863-875.
50. Lerner, MR and Steitz, JA: Antibodies to small nuclear RNAs complexed with proteins are produced in patients with systemic lupus erythematosus. Proc Nati Acad Sci USA 1979; 76: 5494-5499.
51. Goudsmit, J, Debouck, C, Meloen, RH, Smit, L, Bakker, M, Asher, DA, Wolff, AV, Gibbs, CJ, and Gajdusek, DC: Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees. Proc Nati Acad Sci USA 1988; 85: 4478-4482.
52. Ho, DD, Samgadharan, MG, Hirsch, MS, Schooley, RT, Rota, TR, Kennedy, RC, Chanh, TC, and Sato, VL: Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins. J Virol 1988; 61: 2024-2028.
53. Robinson, WE Jr, Gorny, MK, Xu, JY, Mitchell, WM, and Zolla-Pazner, S: Two immunodominant domains of gp41 bind antibodies which enhance human immunodeficiency virus type 1 infection in vitro. J Virol 1991; 65: 4169-4176.
54. Kowalski, M, Potz, J, Basiripour, L, Dorfman, T, Goh, WC, Terwilliger, E, Dayton, A, Rosen, C, Haseltine, W, and Sodroski, J: Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science 1987; 237: 1351-1355.
55. Chamat, S, Nara, P, Berguist, L, Whalley, A, Morrow, WJW, Kohler, H, and Kang, C-Y: Two major groups of neutralizing anti-gpl20 antibodies exist in HIV-infected individuals. Evidence for epitope diversity around the CD4 attachment site. J Immunol 1992; 149: 649-654.
56. Buchbinder, A, Karwowska, S, Gorny, MK, Burda, ST, and Zolla-Pazner, S: Synergy between human monoclonal antibodies to HIV extends their effective biologic activity against homologous and divergent strains. AIDS Res Hum Retroviruses 1992; 8: 425-427.
57. Eichberg, JW: Experience with thirteen HIV efficacy trials in chimpanzees. VIth International Conference on AIDS, San Francisco, California, 1990 (Abstract Th. 1990;A338).
58. Prince, AM, Horowitz, B, Baker, L, Shulman, RW, Ralph, H, Valinsky, J, Cundell, A, Brotman, B, Boehle, W, Rey, F, Piet, M, Reesink, H, Lelie, N, Tersmette, M, Miedema, F, Barbosa, L, Nemo, G, Nastala, CL, Allan, JS, Lee, DR, and Eichberg, JW: Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV. Proc Nati Acad Sci USA 1988; 85: 6944-6948.
59. Goedert, JJ, Drummond, JE, Minkoff, HL, Stevens, R, Blattner, WA, Mendez, H, Robert-Guroff, M, Holman, S, Rubinstein, A, Willoughby, A, and Landesman, SH: Mother-to-infant transmission of human immunodeficiency virus type-1: Association with prematurity or low anti-gp 120. Lancet 1989; 2: 1351-1354.
60. Rossi, P, Mosechese, V, Broliden, PA, Fundaro, C, Quinti, I, Pleban, A, Giaquinto, C, Tovo, A, Ljunggren, K, Rosen, J, Wigzell, H, Jondal, M, and Wahren, B: Presence of maternal antibodies to human immunodeficiency virus 1 envelope glycoprotein gpl20 epitopes correlates with the uninfected status of children born to seropositive mothers. Proc Nati Acad Sci USA 1989; 86: 8055-8058.
61. Devash, Y, Calvelli, TA, Wood, DG, Reagan, KJ, and Rubinstein, A: Vertical transmission of human immunodeficiency virus is correlated with the absence of high affinity/avidity maternal antibodies to the gpl20 principal neutralizing domain. Proc Nati Acad Sci USA 1990; 87: 3445-3449.
62. Parekh, BS, Shaffer, N, Pau, CP, Abrams, E, Thomas, P, Pollack, H, Bamji, M, Kaul, A, Schochetman, G, Roger, M, George, JR, and the NYC Perinatal HIV Transmission Collaborative Study: Lack of correlation between maternal antibodies to V3 loop peptides of gpl20 and perinatal HIV-1 transmission. AIDS 1991; 5: 1179-1184.
63. Halsey, NA, Markham, R, Wahren, B, Boulos, R, Rossi, P, and Wigzell, H: Lack of association between maternal antibodies to V3 loop peptides and maternal-infant HIV-1 transmission. J Acq Immune Defic Syndr 1992; 5: 153-157.
64. Emini, EA, Schleif, WA, Nunberg, JH, Conley, RJ, Eda, Y, Tokiyoshi, S, Putney, SD, Matsushita, S, Cobb, KE, Jett, CM, Eichberg, JW, and Murthy, KK: Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody. Nature (London) 1992; 355: 728-730.