Antioxidant vitamins — benefits not yet proved

New England Journal of Medicine

Volumn 330, Issue 15, 1994, Pages 1080-1081

  Hennekens, Charles H ^a   Buring, Julie E ^a   Peto, Richard ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE;

CANCER PREVENTION; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; EDITORIAL; FEMALE; HUMAN; LUNG CANCER; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTATE CANCER; SMOKING; STROKE;

ANTIOXIDANTS; BETA CAROTENE; CARDIOVASCULAR DISEASES; CAROTENOIDS; FEMALE; HUMAN; LUNG NEOPLASMS; MALE; MIDDLE AGE; VITAMIN E;

EID: 0028220252     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199404143301510     Document Type: Editorial

References (15)

1. Peto R, Doll R, Buckley JD, Sporn MB Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290: 201-208
2. Packer L Protective role of vitamin E in biological systems. Am J Clin Nutr 1991; 53: Suppl: 1050s-1055s
3. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-924
4. Keaney JF Jr, Gaziano JM, Xu A, Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci U S A 1993; 90: 11880-11884
5. Hennekens CH, Stampfer MJ, Willett W Micronutrients and cancer chemoprevention. Cancer Detect Prev 1984; 7: 147-158
6. Hennekens CH Micronutrients and cancer prevention. N Engl J Med 1986; 315: 1288-1289
7. Gaziano JM, Manson JE, Buring JE, Hennekens CH Dietary antioxidants and cardiovascular disease. Ann N Y Acad Sci 1992; 669: 249-259
8. Hennekens CH, Buring JE. Epidemiology in medicine. Boston: Little, Brown, 1987.
9. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330: 1029-1035
10. Doll R, Peto R The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981; 66: 1198-1308
11. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993; 328: 1444-1449
12. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993; 328: 1450-1456
13. Hennekens CH, Eberlein K A randomized trial of aspirin and beta-carotene among U.S. physicians. Prev Med 1985; 14: 165-168
14. Buring JE, Hennekens CH The Women's Health Study: summary of the study design. J Myocard Ischemia 1992; 4: 27-29
15. Hatch O. S.183. A bill to amend the Federal Food, Drug, and Cosmetic Act to establish standards with respect to dietary supplements, and for other purposes. 103d Congress, 1st Session, 1993. Washington, D.C.: Government Printing Office, 1993.