Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β

Journal of Clinical Investigation

Volumn 93, Issue 2, 1994, Pages 536-542

  Ziyadeh, Fuad N ^a,c   Sharma, Kumar ^a   Ericksen, Mark ^a   Wolf, Gunter ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

collagen type I; collagen type IV; diabetic glomerulopathy; extracellular matrix; mouse kidney

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; GLUCOSE; IMMUNOGLOBULIN G; MESSENGER RNA; NEUTRALIZING ANTIBODY; PROLINE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CULTURE MEDIUM; DIABETIC NEPHROPATHY; EXTRACELLULAR MATRIX; GENE EXPRESSION; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0028218461     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117004     Document Type: Article

References (48)

1. Hosteller, T. H. 1986. The progressive nature of renal disease. In Contemporary Issues in Nephrology. W. E. Mitch, editor. Churchill-Livingstone, Inc., New York. pp. 149-166.
2. Kreisberg, J. I., and S. H. Ayo. 1993. The glomerular mesangium in diabetes mellitus. Kidney Int. 43:109-113.
3. Nerlich, A., and E. Schleicher. 1991. Immunohistochemical localization of exlracellular matrix components in human diabetic glomerular lesions. Am. J. Pathol. 139:889-899.
4. Ziyadeh, F. N., S. Goldfarb, and E. F. O. Kern. 1989. Diabetic nephropathy: metabolic and biochemical mechanisms. In Contemporary Issues in Nephrology 20. The Kidney in Diabetes Mellitus. B. M. Brenner and J. H. Stein, editors. Churchill-Livingstone, Inc., New York. pp. 87-113.
5. Mauer, S. M., M. W. Steffes, E. N. Ellis, D. E. R. Sutherland, D. N. Brown, and F. C. Goetz. 1984. Structural-functional relationships in diabetic nephropathy. J. Clin. Invest. 74:1143-1155.
6. Osterby, R. 1992. Glomerular structural changes in type I (insulin-dependent) diabetes mellitus: causes, consequences, and prevention. Diabetologia. 35:803-812.
7. Steffes, M. W., R. W. Bilous, D. E. R. Sutherland, and S. M. Mauer. 1992. Cell and matrix components of the glomerular mesangium in type I diabetes. Diabetes. 41:679-684.
8. Ziyadeh, F. N., and S. Goldfarb. 1991 The renal tubulointerstitium in diabetes mellitus. Kidney Int. 39:464-475.
9. Ziyadeh, F. N. 1993. Renal tubular basement membrane and collagen type IV in diabetes mellitus. Kidney Int. 43:114-120.
10. Ihm, C. G., G. S. L. Lee, C. C. Nast, A. Artishevsky, R. Guillermo, P. S. Levin, R. J. Glassock, and S. G. Adler. 1992. Early increased renal procollagen α1(IV) mRNA levels in streptozotocin induced diabetes. Kidney Int. 41:768-777.
11. Ledbetter, S., E. J. Copeland, D. Noonan, G. Vogeli, and J. R. Hassell. 1990. Altered steady-state mRNA levels of basement membrane proteins in diabetic mouse kidneys and thromboxane synthase inhibition. Diabetes. 39:196-203.
12. Poulsom, R., M. Kurkinen, D. J. Prockop, and R. P. Boot-Hanford. 1988. Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of aldose reduclase inhibitor. J. Biol. Chem. 263:10072-10076.
13. Roy, S., R. Sala, E. Cagliero, and M. Lorenzi. 1990. Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory. Proc. Natl. Acad. Sci. USA. 87:404-408.
14. Fukui, M., T. Nakamura, I. Ebihara, I. Shirato, Y. Tomino, and H. Koide. 1992. ECM gene expression and its modulation by insulin in diabetic rats. Diabetes. 41:1520-1527.
15. Crowley, S. T., M. Brownlee, D. Edelstein, J. A. Satriano, T. Mori, P. C. Singhal, and D. O. Schlondorff. 1991. Effects of nonenzymatic glycosylation of mesangial matrix on proliferation of mesangial cells. Diabetes. 40:540-547.
16. Ziyadeh, F. N., D. A. Simmons, E. R. Snipes, and S. Goldfarb. 1991. Effect of myoinositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose. J. Am. Soc. Nephrol. 1:1220-1229.
17. Ziyadeh, F. N., E. R. Snipes, M. Watanabe, R. J. Alvarez, S. Goldfarb, and T. P. Haverty. 1990. High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am. J. Physiol. 259:F704-F714.
18. Ayo, S. H., R. A. Radnik, J. A. Garoni, W. F. Glass II, and J. I. Kreisberg. 1990. High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells. Am. J. Pathol. 136:1339-1348.
19. Ayo, S. H., R. A. Radnik, W. F. Glass II, J. A. Garoni, E. R. Rampt, D. R. Appling, and J. I. Kreisberg. 1991. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium. Am. J. Physiol. 260:F185-F191.
20. Danne, T., M. J. Spiro, and R. G. Spiro. 1993. Effect of high glucose on type IV collagen in cultured rat glomerular epithelial, endothelial, and mesangial cells. Diabetes. 42:170-177.
21. Haneda, M., R. Kikkawa, N. Horide, M. Togawa, D. Koya, N. Kajiwara, A. Ooshima, and Y. Shigeta. 1991. Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells. Diabetologia. 34:198-200.
22. Nahman, N. S., K. L. Leonhart, F. G. Cosio, and C. L. Hebert. 1992. Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells. Kidney Int. 41:396-402.
23. Studer, R. K., P. A. Craven, and F. R. DeRubertis. 1993. Role of protein Kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium. Diabetes. 42:118-126.
24. Rocco, M. V., Y. Chen, S. Goldfarb, and F. N. Ziyadeh. 1992. Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule. Kidney Int. 41:107-114.
25. Wolf, G., E. G. Neilson, S. Goldfarb, and F. N. Ziyadeh. 1991. The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture. Biochem. Biophys. Res. Commun. 176:902-909.
26. Wolf, G., K. Sharma, Y. Chen, M. Ericksen, and F. N. Ziyadeh. 1992. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β Kidney Int. 42:647-656.
27. 1. Nature (Lond.) 346:371-374.
28. Border, W. A., N. A. Noble, T. Yamamoto, J. R. Harper, Y. Yamaguchi, M. D. Pierschbacher, and E. Rusolahti. 1992. Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease. Nature (Lond.) 360:361-364.
29. 1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence. Cell. 61:267-278.
30. Roberts, A. B., B. K. McCune, and M. B. Sporn. 1992. TGF-β: Regulation of extracellular matrix. Kidney Int. 41:557-559.
31. Rocco, M. V., and F. N. Ziyadeh. 1991. Transforming growth factor-beta: an update on systemic and renal actions. In Hormones, Autacoids, and the Kidney. Contemporary Issues in Nephrology. S. Goldfarb and F. N. Ziyadeh, editors. Churchill-Livingstone, Inc., New York. pp. 391-410.
32. Sharma, K., and F. N. Ziyadeh. 1993. The transforming growth factor-β system and the kidney. Sem. Nephrol. 13:116-128.
33. Wolf, G., U. Haberstroh, and E. G. Neilson. 1992. Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells. Am. J. Pathol. 140:95-107.
34. Wolf, G., F. Thaiss, W. Schoeppe, and R. A. K. Stahl. 1992. Angiotensin II-induced proliferation of cultured murine mesangial cells: inhibitory role of atrial natriuretic peptide. J. Am. Soc. Nephrol. 3:1270-1278.
35. Haralson, M. A., H. R. Jacobson, and R. L. Hoover. 1987. Collagen polymorphism in cultured rat kidney mesangial cells. Lab. Invest. 57:513-523.
36. Ohyama, K., J. M. Seyer, R. Raghow, and A. H. Kang. 1990. Extracellular matrix phenotype of rat mesangial cells in culture. Biosynthesis of collagen types I, III, IV, and V and a low molecular weight collagenous component and their regulation by dexamethasone. J. Lab. Clin. Med. 116:219-227.
37. Scherberich, J. E., P. Fischer, A. Bigalke, P. Stangl, G. Wolf, M. Haimerl, and W. Schoeppe. 1989. Routine diagnosis with PhasSystem compared to conventional electrophoresis: automated sodium dodecyl sulfate-polyacrylamide gel electrophoresis, silver staining and Western blotting of urinary proteins. Electrophoresis. 10:58-62.
38. Wolf, G., and E. G. Neilson. 1990. Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells. Am. J. Physiol. 259:F768-F777.
39. Liau, G., Y. Yamada, and B. De Crombrugghe. 1985. Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts. J. Biol. Chem. 260:531-536.
40. Myers, J. C., J. M. Brinker, N. A. Kefalides, J. Rosenbloom, S. Y. Wang, and L. J. Gudas. 1986. Discrimination among multiple AATAAA sequences correlates with interspecies conservation of select 3′ untranslated nucleotides. Nucleic Acids Res. 14:4499-4517.
41. Okuda, S., L. R. Languino, E. Ruoslahti, and W. A. Border. 1990. Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. J. Clin. Invest. 86:453-462.
42. MacKay, K., L. J. Striker, J. W. Stauffer, T. Doi, L. Y. Agodoa, and G. E. Striker. 1989. Transforming growth factor-β. Murine glomerular receptors and responses of isolated glomerular cells. J. Clin. Invest. 83:1160-1167.
43. Ishimura, E., R. B. Sterzel, and M. Kashgarian. 1990. Effect of transforming growth factor (TGF)-β on extracellular matrix (ECM) production by cultured rat mesangial cells (abstract). Kidney Int. 37:197.
44. De Chrombrugghe, B., G. Karsenty, S. Maity, T. Vuorio, P. Rossi, E. C. Ruteshouser, S. H. McKinney, and G. Lozano. 1990. Transcriptional mechanisms controlling types I and III collagen genes. Ann. NY Acad. Sci. 580:88-96.
45. Kuncio, G. S., P. Killen, and E. G. Neilson. 1990. Modulated expression of the α1(IV) collagen gene in murine tubular cells cultured with fibrosis-relevant cytokines (abstract). J. Am. Soc. Nephrol. 1:551.
46. Paralkar, V. M., S. Vukicevic, and A. H. Reddi. 1991. Transforming growth factor β type I binds to collagen IV of basement membrane matrix: implication for development. Dev. Biol. 143:303-308.
47. Wolf, G., E. Mueller, R. A. K. Stahl, and F. N. Ziyadeh. 1993. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells in culture. J. Clin. Invest. 92:1366-1372.
48. Sharma, K., M. Ericksen, S. Goldfarb, and F. N. Ziyadeh. 1992. Up-regulation of kidney transforming growth factor-β (TGF-β) gene expression in two rodent models of spontaneous diabetes mellitus. J. Am. Soc. Nephrol. 3:766. (Abstr.)