메뉴 건너뛰기




Volumn 83, Issue 7, 1994, Pages 1717-1730

Immunoglobulin V regions and the B cell

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; B LYMPHOCYTE; GENE REARRANGEMENT; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; PRIORITY JOURNAL; REVIEW;

EID: 0028217004     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v83.7.1717.1717     Document Type: Review
Times cited : (94)

References (225)
  • 3
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S: Somatic generation of antibody diversity. Nature 302:575, 1983
    • (1983) Nature , vol.302 , pp. 575
    • Tonegawa, S.1
  • 4
    • 0018173128 scopus 로고
    • The arrangement and rearrangement of antibody genes
    • Seidman JG, Leder P: The arrangement and rearrangement of antibody genes. Nature 276:790, 1978
    • (1978) Nature , vol.276 , pp. 790
    • Seidman, J.G.1    Leder, P.2
  • 6
    • 0022271336 scopus 로고
    • Origin of immune diversity: Genetic variation and selection
    • Honjo T, Habu S: Origin of immune diversity: Genetic variation and selection. Annu Rev Biochem 54:803, 1985
    • (1985) Annu Rev Biochem , vol.54 , pp. 803
    • Honjo, T.1    Habu, S.2
  • 7
    • 0019135167 scopus 로고
    • Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments
    • Seidman JG, Nau MM, Norman B, Kwan SP, Scharff M, Leder P: Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments. Proc Natl Acad Sci USA 77:6022, 1980
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6022
    • Seidman, J.G.1    Nau, M.M.2    Norman, B.3    Kwan, S.P.4    Scharff, M.5    Leder, P.6
  • 8
    • 0018093829 scopus 로고
    • A complete immunoglobulin gene is created by somatic recombination
    • Brack C, Hirama M, Lenhard S, Tonegawa S: A complete immunoglobulin gene is created by somatic recombination. Cell 15:1, 1978
    • (1978) Cell , vol.15 , pp. 1
    • Brack, C.1    Hirama, M.2    Lenhard, S.3    Tonegawa, S.4
  • 9
    • 0018843979 scopus 로고
    • An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH
    • Early P, Huang H, Davis M, Calame K, Hood L: An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell 19:981, 1980
    • (1980) Cell , vol.19 , pp. 981
    • Early, P.1    Huang, H.2    Davis, M.3    Calame, K.4    Hood, L.5
  • 10
    • 0022773519 scopus 로고
    • VHDJH formation and DJH replacement during pre-B differentiation
    • Reth MG, Jackson S, Alt FW: VHDJH formation and DJH replacement during pre-B differentiation. EMBO J 5:2131, 1986
    • (1986) EMBO J , vol.5 , pp. 2131
    • Reth, M.G.1    Jackson, S.2    Alt, F.W.3
  • 11
    • 0023650302 scopus 로고
    • Physical map of the human immunoglobulin κ locus and its implications for the mechanism of Vκ-Jκ rearrangement
    • Lorenz W, Straubinger B, Zachau HG: Physical map of the human immunoglobulin κ locus and its implications for the mechanism of Vκ-Jκ rearrangement. Nucleic Acids Res 15:9667, 1987
    • (1987) Nucleic Acids Res , vol.15 , pp. 9667
    • Lorenz, W.1    Straubinger, B.2    Zachau, H.G.3
  • 12
    • 0023160805 scopus 로고
    • The human V kappa locus. Characterization of extended immunoglobulin gene regions by cosmid cloning
    • Pohlenz HD, Straubinger B, Thiebe R, Pech M, Zimmer FJ, Zachau HG: The human V kappa locus. Characterization of extended immunoglobulin gene regions by cosmid cloning. J Mol Biol 193:241, 1987
    • (1987) J Mol Biol , vol.193 , pp. 241
    • Pohlenz, H.D.1    Straubinger, B.2    Thiebe, R.3    Pech, M.4    Zimmer, F.J.5    Zachau, H.G.6
  • 14
    • 0027201551 scopus 로고
    • Cloning and sequencing of human immunoglobulin Vλ gene segments
    • Williams SC, Winter G: Cloning and sequencing of human immunoglobulin Vλ gene segments. Eur J Immunol 23:1456, 1993
    • (1993) Eur J Immunol , vol.23 , pp. 1456
    • Williams, S.C.1    Winter, G.2
  • 15
    • 0020051390 scopus 로고
    • Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes
    • Kirsch IR, Morton CC, Nakahara K, Leder P: Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science 216:301, 1982
    • (1982) Science , vol.216 , pp. 301
    • Kirsch, I.R.1    Morton, C.C.2    Nakahara, K.3    Leder, P.4
  • 18
    • 0024293529 scopus 로고
    • Organization of human immunoglobulin heavy chain diversity gene loci
    • Ichihara Y, Matsuoka H, Kurosawa Y: Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J 7:4141, 1988
    • (1988) EMBO J , vol.7 , pp. 4141
    • Ichihara, Y.1    Matsuoka, H.2    Kurosawa, Y.3
  • 19
    • 0019846077 scopus 로고
    • Structure of the human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes
    • Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P: Structure of the human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes. Cell 27:583, 1981
    • (1981) Cell , vol.27 , pp. 583
    • Ravetch, J.V.1    Siebenlist, U.2    Korsmeyer, S.3    Waldmann, T.4    Leder, P.5
  • 20
    • 0024043549 scopus 로고
    • The use of chromosomal translocations to study human immunoglobulin gene organization: Mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus
    • Buluwela L, Albertson DG, Sherrington P, Rabbitts PH, Spurr N, Rabbitts TH: The use of chromosomal translocations to study human immunoglobulin gene organization: Mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus. EMBO J 7:2003, 1988
    • (1988) EMBO J , vol.7 , pp. 2003
    • Buluwela, L.1    Albertson, D.G.2    Sherrington, P.3    Rabbitts, P.H.4    Spurr, N.5    Rabbitts, T.H.6
  • 21
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G: The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 227:776, 1992
    • (1992) J Mol Biol , vol.227 , pp. 776
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 25
    • 0020658557 scopus 로고
    • Evolutionary aspects of immunoglobulin heavy chain variable region (VH) subgroups
    • Rechavi G, Ram D, Glazer L, Zakut R, Givol D: Evolutionary aspects of immunoglobulin heavy chain variable region (VH) subgroups. Proc Natl Acad Sci USA 80:855, 1983
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 855
    • Rechavi, G.1    Ram, D.2    Glazer, L.3    Zakut, R.4    Givol, D.5
  • 26
    • 0027197151 scopus 로고
    • Dispensable sequence motifs in the RAG 1 and RAG 2 genes for plasmid VDJ recombination
    • Silver DP, Spanopoulo E, Mulligan RC, Baltimore D: Dispensable sequence motifs in the RAG 1 and RAG 2 genes for plasmid VDJ recombination. Proc Natl Acad Sci USA 90:6100, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6100
    • Silver, D.P.1    Spanopoulo, E.2    Mulligan, R.C.3    Baltimore, D.4
  • 27
    • 0022549940 scopus 로고
    • Introduced T cell receptor variable region gene segments recombine in pre B cells: Evidence that B and T cells use a common recombinase
    • Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW: Introduced T cell receptor variable region gene segments recombine in pre B cells: Evidence that B and T cells use a common recombinase. Cell 44:251, 1986
    • (1986) Cell , vol.44 , pp. 251
    • Yancopoulos, G.D.1    Blackwell, T.K.2    Suh, H.3    Hood, L.4    Alt, F.W.5
  • 29
    • 0024435908 scopus 로고
    • Activation of immunoglobulin kappa rearrangement correlates with induction of germline kappa gene transcription
    • Schlissel MS, Baltimore D: Activation of immunoglobulin kappa rearrangement correlates with induction of germline kappa gene transcription. Cell 58:1001, 1989
    • (1989) Cell , vol.58 , pp. 1001
    • Schlissel, M.S.1    Baltimore, D.2
  • 31
    • 0027508368 scopus 로고
    • A VDJ recombinase inducible B cell line: Role of transcriptional enhancer elements in directing VDJ recombination
    • Oltz EM, Alt FW, Lin WC, Chen J, Taccioli G, Desiderio S, Rathbun G: A VDJ recombinase inducible B cell line: Role of transcriptional enhancer elements in directing VDJ recombination. Mol Cell Biol 13:6223, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 6223
    • Oltz, E.M.1    Alt, F.W.2    Lin, W.C.3    Chen, J.4    Taccioli, G.5    Desiderio, S.6    Rathbun, G.7
  • 32
    • 0024281345 scopus 로고
    • DNA methylation and gene activity
    • Cedar H: DNA methylation and gene activity. Cell 53:3, 1988
    • (1988) Cell , vol.53 , pp. 3
    • Cedar, H.1
  • 33
    • 0027301927 scopus 로고
    • Methylation status of immunoglobulin kappa gene segments correlates with their recombination potential
    • Goodhardt M, Cavelier P, Doyen N, Kallenbach S, Babinet C, Rougeon F: Methylation status of immunoglobulin kappa gene segments correlates with their recombination potential. Eur J Immunol 23:1789, 1993
    • (1993) Eur J Immunol , vol.23 , pp. 1789
    • Goodhardt, M.1    Cavelier, P.2    Doyen, N.3    Kallenbach, S.4    Babinet, C.5    Rougeon, F.6
  • 34
    • 0027192988 scopus 로고
    • FDJ recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
    • Serwe M, Sablitzky F: FDJ recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J 12:2321, 1993
    • (1993) EMBO J , vol.12 , pp. 2321
    • Serwe, M.1    Sablitzky, F.2
  • 35
    • 0027521610 scopus 로고
    • Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus
    • Chen J, Young F, Bottaro A, Stewart V, Smith RK, Alt FW: Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J 12:4635, 1993
    • (1993) EMBO J , vol.12 , pp. 4635
    • Chen, J.1    Young, F.2    Bottaro, A.3    Stewart, V.4    Smith, R.K.5    Alt, F.W.6
  • 36
    • 0022565521 scopus 로고
    • Regulation of the assembly and expression of variable-region genes
    • Yancopoulos GD, Alt FW: Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol 4:339, 1986
    • (1986) Annu Rev Immunol , vol.4 , pp. 339
    • Yancopoulos, G.D.1    Alt, F.W.2
  • 38
    • 0026583842 scopus 로고
    • Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion
    • Kitamura D, Rajewsky K: Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154, 1992
    • (1992) Nature , vol.356 , pp. 154
    • Kitamura, D.1    Rajewsky, K.2
  • 40
    • 0023688112 scopus 로고
    • Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia
    • Bird J, Galili N, Link M, Stites D, Sklar J: Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J Exp Med 168:229, 1988
    • (1988) J Exp Med , vol.168 , pp. 229
    • Bird, J.1    Galili, N.2    Link, M.3    Stites, D.4    Sklar, J.5
  • 41
    • 0026609784 scopus 로고
    • VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia
    • Wasserman R, Yamada M, Ito Y, Finger LR, Reichard BA, Shane S, Lange B, Rovera G: VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia. Blood 79:223, 1992
    • (1992) Blood , vol.79 , pp. 223
    • Wasserman, R.1    Yamada, M.2    Ito, Y.3    Finger, L.R.4    Reichard, B.A.5    Shane, S.6    Lange, B.7    Rovera, G.8
  • 42
    • 0027509308 scopus 로고
    • Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia
    • Kitchingman GR: Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia. Blood 81:775, 1993
    • (1993) Blood , vol.81 , pp. 775
    • Kitchingman, G.R.1
  • 43
    • 0025308620 scopus 로고
    • Immunoglobulin heavy chain gene rearrangement involving V-V region recombination
    • Deane M, Norton JD: Immunoglobulin heavy chain gene rearrangement involving V-V region recombination. Nucleic Acids Res 18:1652, 1990
    • (1990) Nucleic Acids Res , vol.18 , pp. 1652
    • Deane, M.1    Norton, J.D.2
  • 44
    • 0026761732 scopus 로고
    • Heavy chain variable (VH) region diversity generated by VH gene replacement in the progeny of a single precursor cell transformed with a temperature sensitive mutant of abelson murine leukemia virus
    • Shirasawa T, Miyazoe I, Hagiwara S, Kimoto H, Shigemoto K, Taniguchi M, Takemori T: Heavy chain variable (VH) region diversity generated by VH gene replacement in the progeny of a single precursor cell transformed with a temperature sensitive mutant of abelson murine leukemia virus. J Exp Med 176:1209, 1992
    • (1992) J Exp Med , vol.176 , pp. 1209
    • Shirasawa, T.1    Miyazoe, I.2    Hagiwara, S.3    Kimoto, H.4    Shigemoto, K.5    Taniguchi, M.6    Takemori, T.7
  • 45
    • 0025933761 scopus 로고
    • Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: Correlation with cell differentiation and antigen receptor expression
    • Bories JC, Cayuela JM, Loiseau P, Sigaux F: Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: Correlation with cell differentiation and antigen receptor expression. Blood 78:2053, 1991
    • (1991) Blood , vol.78 , pp. 2053
    • Bories, J.C.1    Cayuela, J.M.2    Loiseau, P.3    Sigaux, F.4
  • 47
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li YS, Hayakawa K, Hardy RR: The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med 178:951, 1993
    • (1993) J Exp Med , vol.178 , pp. 951
    • Li, Y.S.1    Hayakawa, K.2    Hardy, R.R.3
  • 48
    • 0027165531 scopus 로고
    • - variants of a human mature B cell line undergoing secondary Igl rearrangements in cell culture
    • - variants of a human mature B cell line undergoing secondary Igl rearrangements in cell culture. Eur J Immunol 23:1501, 1993
    • (1993) Eur J Immunol , vol.23 , pp. 1501
    • Stiernholm, N.B.J.1    Berinstein, N.L.2
  • 49
    • 0021076098 scopus 로고
    • Immunoglobulin heavy chain binding protein
    • Haas IG, Wabl M: Immunoglobulin heavy chain binding protein. Nature 306:387, 1983
    • (1983) Nature , vol.306 , pp. 387
    • Haas, I.G.1    Wabl, M.2
  • 50
    • 0025766890 scopus 로고
    • Molecular and cellular origins of B lymphocyte diversity
    • Rolink A, Melchers F: Molecular and cellular origins of B lymphocyte diversity. Cell 66:1081, 1991
    • (1991) Cell , vol.66 , pp. 1081
    • Rolink, A.1    Melchers, F.2
  • 51
    • 0027400889 scopus 로고
    • Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation
    • Lassoued K, Nunez CA, Billips L, Kubagawa H, Monteiro RC, LeBien TW, Cooper MD: Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73:73, 1993
    • (1993) Cell , vol.73 , pp. 73
    • Lassoued, K.1    Nunez, C.A.2    Billips, L.3    Kubagawa, H.4    Monteiro, R.C.5    LeBien, T.W.6    Cooper, M.D.7
  • 53
    • 0026077398 scopus 로고
    • Organization of the λ like genes that contribute to the μ-ψ light chain complex in human pre B cells
    • Bossy D, Milili M, Zucman J, Thomas G, Fougereau M, Sciff C: Organization of the λ like genes that contribute to the μ-ψ light chain complex in human pre B cells. Int Immunol 3:1081, 1991
    • (1991) Int Immunol , vol.3 , pp. 1081
    • Bossy, D.1    Milili, M.2    Zucman, J.3    Thomas, G.4    Fougereau, M.5    Sciff, C.6
  • 54
    • 0023710096 scopus 로고
    • The omega and iota surrogate immunoglobulin light chains
    • Pillai S, Baltimore D: The omega and iota surrogate immunoglobulin light chains. Curr Topics Microbiol Immunol 137:136, 1988
    • (1988) Curr Topics Microbiol Immunol , vol.137 , pp. 136
    • Pillai, S.1    Baltimore, D.2
  • 55
    • 0027200965 scopus 로고
    • Architecture of the B cell antigen receptor
    • van Noesl CJM, van Lier RAW: Architecture of the B cell antigen receptor. Blood 82:363, 1993
    • (1993) Blood , vol.82 , pp. 363
    • Van Noesl, C.J.M.1    Van Lier, R.A.W.2
  • 56
    • 0025886823 scopus 로고
    • Alternative rearrangements of immunoglobulin light chain genes in human leukemia
    • Tang JQ, Bene MC, Faure GC: Alternative rearrangements of immunoglobulin light chain genes in human leukemia. Leukemia 5:651, 1991
    • (1991) Leukemia , vol.5 , pp. 651
    • Tang, J.Q.1    Bene, M.C.2    Faure, G.C.3
  • 57
    • 0027216295 scopus 로고
    • Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: Human B cells can simultaneously express cell surface κ and λ light chains
    • Pauza ME, Rehmann JA, LeBien TW: Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: Human B cells can simultaneously express cell surface κ and λ light chains. J Exp Med 170:139, 1993
    • (1993) J Exp Med , vol.170 , pp. 139
    • Pauza, M.E.1    Rehmann, J.A.2    LeBien, T.W.3
  • 61
    • 0025852445 scopus 로고
    • A B cell deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
    • Kitamura D, Roes J, Kuhn R, Rajewsky K: A B cell deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423, 1991
    • (1991) Nature , vol.350 , pp. 423
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.4
  • 63
    • 0026019627 scopus 로고
    • Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin
    • Era T, Ogawa M, Nishikawa S, Okamoto M, Honjo T, Akagi K, Miyazaki J, Yamamura K: Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. EMBO J 10:337, 1991
    • (1991) EMBO J , vol.10 , pp. 337
    • Era, T.1    Ogawa, M.2    Nishikawa, S.3    Okamoto, M.4    Honjo, T.5    Akagi, K.6    Miyazaki, J.7    Yamamura, K.8
  • 68
    • 0026445044 scopus 로고
    • Assembly of IgH CDR3: Mechanism, regulation, and influence on antibody
    • VanDyk L, Meek K: Assembly of IgH CDR3: Mechanism, regulation, and influence on antibody. Int Rev Immunol 8:123, 1992
    • (1992) Int Rev Immunol , vol.8 , pp. 123
    • VanDyk, L.1    Meek, K.2
  • 70
    • 0026559783 scopus 로고
    • Antibody framework residues affecting the conformation of the hypervariable loops
    • Foote J, Winter G: Antibody framework residues affecting the conformation of the hypervariable loops. J Mol Biol 224:487, 1992
    • (1992) J Mol Biol , vol.224 , pp. 487
    • Foote, J.1    Winter, G.2
  • 72
    • 0025781883 scopus 로고
    • Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions
    • Sanz I: Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 147:1720, 1991
    • (1991) J Immunol , vol.147 , pp. 1720
    • Sanz, I.1
  • 73
    • 0026099589 scopus 로고
    • Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes
    • Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 173:395, 1991
    • (1991) J Exp Med , vol.173 , pp. 395
    • Yamada, M.1    Wasserman, R.2    Reichard, B.A.3    Shane, S.4    Caton, A.J.5    Rovera, G.6
  • 74
    • 0025201204 scopus 로고
    • Analysis of junctional diversity during B lymphocyte development
    • Meek K: Analysis of junctional diversity during B lymphocyte development. Science 250:820, 1990
    • (1990) Science , vol.250 , pp. 820
    • Meek, K.1
  • 75
    • 0026492572 scopus 로고
    • Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event
    • Wasserman R, Galili N, Ito Y, Reichard BA, Shane S, Rovera G: Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event. J Exp Med 176:1577, 1992
    • (1992) J Exp Med , vol.176 , pp. 1577
    • Wasserman, R.1    Galili, N.2    Ito, Y.3    Reichard, B.A.4    Shane, S.5    Rovera, G.6
  • 76
    • 0024791338 scopus 로고
    • Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-D-J joining
    • Lafaille JJ, Decloux A, Bonneville M, Takagaki Y, Tonegawa S: Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-D-J joining. Cell 59:859, 1989
    • (1989) Cell , vol.59 , pp. 859
    • Lafaille, J.J.1    Decloux, A.2    Bonneville, M.3    Takagaki, Y.4    Tonegawa, S.5
  • 77
    • 0024477756 scopus 로고
    • Chicken IgL chain rearrangement involves deletion of a circular episome and addition of single non random nucleotides to both coding region segments
    • MacCormack WT, Tjoelker LW, Carlson LM, Petryniak B, Barth CF, Humphries EH, Thompson CB: Chicken IgL chain rearrangement involves deletion of a circular episome and addition of single non random nucleotides to both coding region segments. Cell 56:785, 1989
    • (1989) Cell , vol.56 , pp. 785
    • MacCormack, W.T.1    Tjoelker, L.W.2    Carlson, L.M.3    Petryniak, B.4    Barth, C.F.5    Humphries, E.H.6    Thompson, C.B.7
  • 78
    • 0026801415 scopus 로고
    • The mechanism of V(D)J recombination: A balance of diversity, specificity and stability
    • Lieber MR: The mechanism of V(D)J recombination: A balance of diversity, specificity and stability. Cell 70:873, 1992
    • (1992) Cell , vol.70 , pp. 873
    • Lieber, M.R.1
  • 79
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (Hairpin) coding ends in SCID mouse thymocytes
    • Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M: V(D)J recombination: Broken DNA molecules with covalently sealed (Hairpin) coding ends in SCID mouse thymocytes. Cell 70:983, 1992
    • (1992) Cell , vol.70 , pp. 983
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 80
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of the antibody repertoire in the mouse
    • Rajewsky K, Forster I, Cumano A: Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238:1088, 1987
    • (1987) Science , vol.238 , pp. 1088
    • Rajewsky, K.1    Forster, I.2    Cumano, A.3
  • 81
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek C, Milstein C: Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev 96:23, 1987
    • (1987) Immunol Rev , vol.96 , pp. 23
    • Berek, C.1    Milstein, C.2
  • 82
    • 0022503258 scopus 로고
    • Somatic evolution of variable region structures during an immune response
    • Wysocki L, Manser T, Gefter ML: Somatic evolution of variable region structures during an immune response. Proc Natl Acad Sci USA 83:1847, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1847
    • Wysocki, L.1    Manser, T.2    Gefter, M.L.3
  • 83
    • 0003575039 scopus 로고
    • Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
    • Kocks C, Rajewsky K: Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. Proc Natl Acad Sci USA 85:8206, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8206
    • Kocks, C.1    Rajewsky, K.2
  • 84
    • 0024496737 scopus 로고
    • Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten
    • Sharon J, Gefter ML, Wysocki LJ, Margolies MN: Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten. J Immunol 142:596, 1989
    • (1989) J Immunol , vol.142 , pp. 596
    • Sharon, J.1    Gefter, M.L.2    Wysocki, L.J.3    Margolies, M.N.4
  • 87
    • 0026772275 scopus 로고
    • Immunoglobulin heavy chain gene expression in peripheral blood B cells
    • Huang C, Stewart AK, Schwartz RS, Stollar BD: Immunoglobulin heavy chain gene expression in peripheral blood B cells. J Clin Invest 89:1331, 1992
    • (1992) J Clin Invest , vol.89 , pp. 1331
    • Huang, C.1    Stewart, A.K.2    Schwartz, R.S.3    Stollar, B.D.4
  • 88
    • 0026786650 scopus 로고
    • High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire
    • van Es JH, Gmelig Meyling FHJ, Logtenberg T: High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire. Eur J Immunol 22:2761, 1992
    • (1992) Eur J Immunol , vol.22 , pp. 2761
    • Van Es, J.H.1    Gmelig Meyling, F.H.J.2    Logtenberg, T.3
  • 89
    • 0027095905 scopus 로고
    • Probing the human antibody repertoire to exogenous antigens
    • Andris JS, Ehrlich PH, Ostberg L, Capra JD: Probing the human antibody repertoire to exogenous antigens. J Immunol 149:4053, 1992
    • (1992) J Immunol , vol.149 , pp. 4053
    • Andris, J.S.1    Ehrlich, P.H.2    Ostberg, L.3    Capra, J.D.4
  • 90
    • 0027382370 scopus 로고
    • A majority of immunoglobulin H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies
    • Huang C, Stollar BD: A majority of immunoglobulin H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies. J Immunol 151:5290, 1993
    • (1993) J Immunol , vol.151 , pp. 5290
    • Huang, C.1    Stollar, B.D.2
  • 92
    • 0027336440 scopus 로고
    • Use of the most JH proximal human Ig H chain V region gene VH6 in the expressed immune repertoire
    • Varade WS, Marin E, Kittelberger AM, Insel RA: Use of the most JH proximal human Ig H chain V region gene VH6 in the expressed immune repertoire. J Immunol 10:4985, 1993
    • (1993) J Immunol , vol.10 , pp. 4985
    • Varade, W.S.1    Marin, E.2    Kittelberger, A.M.3    Insel, R.A.4
  • 93
    • 0027159113 scopus 로고
    • Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed Cα and Cγ repertoires
    • Mortari F, Wang JY, Schroeder HW Jr: Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed Cα and Cγ repertoires. J Immunol 150:1348, 1993
    • (1993) J Immunol , vol.150 , pp. 1348
    • Mortari, F.1    Wang, J.Y.2    Schroeder Jr., H.W.3
  • 94
    • 0027460052 scopus 로고
    • Molecular evolution of the human immunoglobulin E response: High incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis
    • van der Stoep N, van der Linden J, Logtenberg T: Molecular evolution of the human immunoglobulin E response: High incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis. J Exp Med 177:99, 1993
    • (1993) J Exp Med , vol.177 , pp. 99
    • Van Der Stoep, N.1    Van Der Linden, J.2    Logtenberg, T.3
  • 96
    • 0026612980 scopus 로고
    • VH-gene representation in autoantibodies reflects the normal human B-cell repertoire
    • Stewart AK, Huang C, Long AA, Stollar BD, Schwartz RS: VH-gene representation in autoantibodies reflects the normal human B-cell repertoire, Immunol Rev 128:101, 1992
    • (1992) Immunol Rev , vol.128 , pp. 101
    • Stewart, A.K.1    Huang, C.2    Long, A.A.3    Stollar, B.D.4    Schwartz, R.S.5
  • 97
  • 99
    • 0025041887 scopus 로고
    • Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life
    • Schroeder HW Jr, Wang JY: Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci USA 37:6146, 1990
    • (1990) Proc Natl Acad Sci USA , vol.37 , pp. 6146
    • Schroeder Jr., H.W.1    Wang, J.Y.2
  • 100
    • 0026558787 scopus 로고
    • Restricted utilization of germ-line VH3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements
    • Raaphorst FM, Timmers E, Kenter MJ, VanTol MJ, Vossen JM, Schuurman RK: Restricted utilization of germ-line VH3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements. Eur J Immunol 22:247, 1992
    • (1992) Eur J Immunol , vol.22 , pp. 247
    • Raaphorst, F.M.1    Timmers, E.2    Kenter, M.J.3    VanTol, M.J.4    Vossen, J.M.5    Schuurman, R.K.6
  • 101
    • 0026495452 scopus 로고
    • Emerging human B cell repertoire - Influence of developmental stage and interindividual variation
    • Hillson J, Oppliger IR, Sasso EH, Milner ECB, Wener MH: Emerging human B cell repertoire - Influence of developmental stage and interindividual variation. J Immunol 149:3741, 1992
    • (1992) J Immunol , vol.149 , pp. 3741
    • Hillson, J.1    Oppliger, I.R.2    Sasso, E.H.3    Milner, E.C.B.4    Wener, M.H.5
  • 102
    • 0026502877 scopus 로고
    • The human cord blood antibody repertoire. Frequent usage of the VH7 gene family
    • Mortari F, Newton JA, Wang JY, Schroeder HW Jr: The human cord blood antibody repertoire. Frequent usage of the VH7 gene family. Eur J Immunol 22:241, 1992
    • (1992) Eur J Immunol , vol.22 , pp. 241
    • Mortari, F.1    Newton, J.A.2    Wang, J.Y.3    Schroeder Jr., H.W.4
  • 103
    • 0026612911 scopus 로고
    • The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B cell precursor stage
    • Wasserman R, Ito Y, Galili N, Yamada M, Reichard BA, Shane S, Lange B, Rovera G: The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B cell precursor stage. J Immunol 149:511, 1992
    • (1992) J Immunol , vol.149 , pp. 511
    • Wasserman, R.1    Ito, Y.2    Galili, N.3    Yamada, M.4    Reichard, B.A.5    Shane, S.6    Lange, B.7    Rovera, G.8
  • 104
    • 0025742731 scopus 로고
    • Preferential rearrangement of developmentally regulated immunoglobulin VH1 genes in human B-lineage cells
    • Deane M, Norton JD: Preferential rearrangement of developmentally regulated immunoglobulin VH1 genes in human B-lineage cells. Leukemia 5:646, 1991
    • (1991) Leukemia , vol.5 , pp. 646
    • Deane, M.1    Norton, J.D.2
  • 105
    • 0026071128 scopus 로고
    • The expression of the IgH chain repertoire in developing bone marrow B lineage cells
    • Decker DJ, Boyle NE, Koziol JA, Klinman NR: The expression of the IgH chain repertoire in developing bone marrow B lineage cells. J Immunol 146:350, 1991
    • (1991) J Immunol , vol.146 , pp. 350
    • Decker, D.J.1    Boyle, N.E.2    Koziol, J.A.3    Klinman, N.R.4
  • 106
    • 0026633168 scopus 로고
    • Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult
    • Braun J, Berberian L, King L, Sanz I, Govan HL III: Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult. J Clin Invest 89:1395, 1992
    • (1992) J Clin Invest , vol.89 , pp. 1395
    • Braun, J.1    Berberian, L.2    King, L.3    Sanz, I.4    Govan III, H.L.5
  • 107
    • 0027409765 scopus 로고
    • High-frequency representation of a single VH gene in the expressed human B cell repertoire
    • Stewart AK, Huang C, Stollar BD, Schwartz RS: High-frequency representation of a single VH gene in the expressed human B cell repertoire. J Ex Med 177:409, 1993
    • (1993) J Ex Med , vol.177 , pp. 409
    • Stewart, A.K.1    Huang, C.2    Stollar, B.D.3    Schwartz, R.S.4
  • 108
    • 0027050981 scopus 로고
    • Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin VH genes, but not VL genes
    • Huang DF, Olee T, Masuho Y, Matsumoto Y, Carson DA, Chen PP: Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin VH genes, but not VL genes. J Clin Invest 90:2197, 1992
    • (1992) J Clin Invest , vol.90 , pp. 2197
    • Huang, D.F.1    Olee, T.2    Masuho, Y.3    Matsumoto, Y.4    Carson, D.A.5    Chen, P.P.6
  • 109
    • 0025787513 scopus 로고
    • Restricted IgH chain V gene usage in the human antibody response to Hemophilus influenza type B capsular polysaccharide
    • Adderson EE, Shackelford PG, Quinn A, Carroll WL: Restricted IgH chain V gene usage in the human antibody response to Hemophilus influenza type B capsular polysaccharide. J Immunol 147:1667, 1991
    • (1991) J Immunol , vol.147 , pp. 1667
    • Adderson, E.E.1    Shackelford, P.G.2    Quinn, A.3    Carroll, W.L.4
  • 110
    • 0026049326 scopus 로고
    • Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of hemophilus influenza type B
    • Silverman GJ, Lucas AH: Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of hemophilus influenza type B. J Clin Invest 88:911, 1991
    • (1991) J Clin Invest , vol.88 , pp. 911
    • Silverman, G.J.1    Lucas, A.H.2
  • 111
    • 0027340737 scopus 로고
    • Immunoglobulin VH3 gene products: Natural ligands for HIV gp120
    • Berberian L, Goodglick L, Kipps TJ, Braun J: Immunoglobulin VH3 gene products: Natural ligands for HIV gp120. Science 261:1588, 1993
    • (1993) Science , vol.261 , pp. 1588
    • Berberian, L.1    Goodglick, L.2    Kipps, T.J.3    Braun, J.4
  • 112
    • 0026610470 scopus 로고
    • VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire
    • Pascual V, Capra JD: VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arth Rheum 35:11, 1992
    • (1992) Arth Rheum , vol.35 , pp. 11
    • Pascual, V.1    Capra, J.D.2
  • 113
    • 0344212391 scopus 로고
    • Structure and multiplicity of genes for the human immunoglobulin heavy chain gene segment
    • Matthyssens G, Rabbitts RH: Structure and multiplicity of genes for the human immunoglobulin heavy chain gene segment. Proc Natl Acad Sci USA 77:6561, 1980
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6561
    • Matthyssens, G.1    Rabbitts, R.H.2
  • 115
    • 0025195278 scopus 로고
    • Cloning and sequence analysis of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia
    • Spatz LA, Wong KK, Williams M, Desal R, Golier J, Berman JE, Alt FW, Latov N: Cloning and sequence analysis of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. J Immunol 144:2821, 1990
    • (1990) J Immunol , vol.144 , pp. 2821
    • Spatz, L.A.1    Wong, K.K.2    Williams, M.3    Desal, R.4    Golier, J.5    Berman, J.E.6    Alt, F.W.7    Latov, N.8
  • 116
  • 118
    • 0026740330 scopus 로고
    • Analysis of immunoglobulin variable region genes from human IgG anti-DNA antibodies
    • Winkler TH, Fehr H, Kalden JR: Analysis of immunoglobulin variable region genes from human IgG anti-DNA antibodies. Eur J Immunol 22:1719, 1992
    • (1992) Eur J Immunol , vol.22 , pp. 1719
    • Winkler, T.H.1    Fehr, H.2    Kalden, J.R.3
  • 119
    • 0025991861 scopus 로고
    • Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody associated cross reactive idiotypes
    • Kipps TJ, Duffy SF: Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody associated cross reactive idiotypes. J Clin Invest 87:2087, 1991
    • (1991) J Clin Invest , vol.87 , pp. 2087
    • Kipps, T.J.1    Duffy, S.F.2
  • 120
    • 0023267620 scopus 로고
    • High frequency expression of a conserved kappa light chain variable region gene in chronic lymphocytic leukemia
    • Kipps TJ, Fong S, Tomhave E, Chen PP, Goldfien RD, Carson DA: High frequency expression of a conserved kappa light chain variable region gene in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 84:2916, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2916
    • Kipps, T.J.1    Fong, S.2    Tomhave, E.3    Chen, P.P.4    Goldfien, R.D.5    Carson, D.A.6
  • 121
    • 0023937436 scopus 로고
    • Autoantibody associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy
    • Kipps TJ, Tomhave E, Chen PP, Carson DA: Autoantibody associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. J Exp Med 167:840, 1988
    • (1988) J Exp Med , vol.167 , pp. 840
    • Kipps, T.J.1    Tomhave, E.2    Chen, P.P.3    Carson, D.A.4
  • 122
    • 0024843715 scopus 로고
    • Idiotypic and molecular characterization of human rheumatoid factors
    • Chen PP, Silverman GJ, Liu MF, Carson DA: Idiotypic and molecular characterization of human rheumatoid factors. Chem Immunol 48:63, 1990
    • (1990) Chem Immunol , vol.48 , pp. 63
    • Chen, P.P.1    Silverman, G.J.2    Liu, M.F.3    Carson, D.A.4
  • 123
    • 0027316190 scopus 로고
    • Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases
    • Kipps TJ, Carson DA: Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood 81:2475, 1993
    • (1993) Blood , vol.81 , pp. 2475
    • Kipps, T.J.1    Carson, D.A.2
  • 124
    • 0025812066 scopus 로고
    • Autoantibody-encoding kappa L chain genes frequently rearranged in lambda light chain expressing chronic lymphocytic leukemia
    • Rassenti LZ, Pratt LF, Chen PP, Carson DA, Kipps TJ: Autoantibody-encoding kappa L chain genes frequently rearranged in lambda light chain expressing chronic lymphocytic leukemia. J Immunol 147:1060, 1991
    • (1991) J Immunol , vol.147 , pp. 1060
    • Rassenti, L.Z.1    Pratt, L.F.2    Chen, P.P.3    Carson, D.A.4    Kipps, T.J.5
  • 125
    • 0027399223 scopus 로고
    • Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequence
    • Asarnow DM, Cado D, Raulet DH: Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequence. Nature 362:158, 1993
    • (1993) Nature , vol.362 , pp. 158
    • Asarnow, D.M.1    Cado, D.2    Raulet, D.H.3
  • 126
    • 0027465645 scopus 로고
    • Restriction fragment length polymorphisms and single germline coding region sequence in VH18/2 a duplicated gene encoding autoantibody
    • Rubinstein DB, Symann M, Stewart AK, Guillaume T: Restriction fragment length polymorphisms and single germline coding region sequence in VH18/2 a duplicated gene encoding autoantibody. Mol Immunol 30:403, 1993
    • (1993) Mol Immunol , vol.30 , pp. 403
    • Rubinstein, D.B.1    Symann, M.2    Stewart, A.K.3    Guillaume, T.4
  • 127
    • 0025302613 scopus 로고
    • The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements
    • Chen PP, Soto G, Carson DA: The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements. Scand J Immunol 31:673, 1990
    • (1990) Scand J Immunol , vol.31 , pp. 673
    • Chen, P.P.1    Soto, G.2    Carson, D.A.3
  • 130
    • 0025184433 scopus 로고
    • The physical organization of the human immunoglobulin heavy chain gene
    • Walter MA, Surti U, Hofker MH, Cox DW: The physical organization of the human immunoglobulin heavy chain gene. EMBO J 9:3303, 1990
    • (1990) EMBO J , vol.9 , pp. 3303
    • Walter, M.A.1    Surti, U.2    Hofker, M.H.3    Cox, D.W.4
  • 131
    • 0026480511 scopus 로고
    • Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire
    • Willems vanDijk K, Milner LA, Sasso EH, Milner EC: Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire. Proc Natl Acad Sci USA 89:10430, 1992
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10430
    • Willems VanDijk, K.1    Milner, L.A.2    Sasso, E.H.3    Milner, E.C.4
  • 132
    • 0026610950 scopus 로고
    • Predominance of VH-D-JH junctions occurring at sites of short sequence homology
    • Feeney AJ: Predominance of VH-D-JH junctions occurring at sites of short sequence homology. J Immunol 149:222, 1992
    • (1992) J Immunol , vol.149 , pp. 222
    • Feeney, A.J.1
  • 133
    • 0027183403 scopus 로고
    • Extent to which homology can constrain coding exon junctional diversity in V (D) J recombination
    • Gerstein RM, Lieber MR: Extent to which homology can constrain coding exon junctional diversity in V (D) J recombination. Nature 363:625, 1993
    • (1993) Nature , vol.363 , pp. 625
    • Gerstein, R.M.1    Lieber, M.R.2
  • 134
    • 0027502540 scopus 로고
    • Restricted κ chain expression in early ontogeny: Biased utilization of Vκ exons and preferential VκJκ recombinations
    • Medina CA, Teale JM: Restricted κ chain expression in early ontogeny: Biased utilization of Vκ exons and preferential VκJκ recombinations. J Exp Med 177:1317, 1993
    • (1993) J Exp Med , vol.177 , pp. 1317
    • Medina, C.A.1    Teale, J.M.2
  • 135
    • 0026253251 scopus 로고
    • DH reading frame bias:evolutionary selection, antigen selection or both
    • Gu H, Kitamura D, Rajewsky K: DH reading frame bias:evolutionary selection, antigen selection or both. Immunol Today 12:420, 1991
    • (1991) Immunol Today , vol.12 , pp. 420
    • Gu, H.1    Kitamura, D.2    Rajewsky, K.3
  • 136
    • 0025808214 scopus 로고
    • Predominance of non productive rearrangements of VH81X gene segments: Evidence a dependence of B cell clonal maturation on the structure of nascent H chains
    • Decker DJ, Boyle NE, Klinman NR: Predominance of non productive rearrangements of VH81X gene segments: Evidence a dependence of B cell clonal maturation on the structure of nascent H chains. J Immunol 147:1406, 1991
    • (1991) J Immunol , vol.147 , pp. 1406
    • Decker, D.J.1    Boyle, N.E.2    Klinman, N.R.3
  • 137
    • 0027369562 scopus 로고
    • Lack of N regions in antigen receptor variable region genes of TdT deficient lymphocytes
    • Komori T, Okada A, Stewart V, Alt FW: Lack of N regions in antigen receptor variable region genes of TdT deficient lymphocytes. Science 261:1171, 1993
    • (1993) Science , vol.261 , pp. 1171
    • Komori, T.1    Okada, A.2    Stewart, V.3    Alt, F.W.4
  • 138
    • 0027452074 scopus 로고
    • Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
    • Gilfillan S, Dierich A, Lemeur M, Benoist C, Mathis D: Mice lacking TdT: Mature animals with an immature lymphocyte repertoire. Science 261:1175, 1993
    • (1993) Science , vol.261 , pp. 1175
    • Gilfillan, S.1    Dierich, A.2    Lemeur, M.3    Benoist, C.4    Mathis, D.5
  • 139
    • 0027461764 scopus 로고
    • Restricted immunoglobulin junctional diversity in neonatal B cells
    • Pandey A, Tjoelker LW, Thompson CB: Restricted immunoglobulin junctional diversity in neonatal B cells. J Exp Med 177:329, 1993
    • (1993) J Exp Med , vol.177 , pp. 329
    • Pandey, A.1    Tjoelker, L.W.2    Thompson, C.B.3
  • 140
    • 0026611386 scopus 로고
    • VH restriction among human cold agglutinins. the VH4-21 gene segment is required to encode anti-i and anti-I specificities
    • Pascual V, Victor K, Spellerberg M, Hamblin TJ, Stevenson K, Capra JD: VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-i and anti-I specificities. J Immunol 149:2337, 1992
    • (1992) J Immunol , vol.149 , pp. 2337
    • Pascual, V.1    Victor, K.2    Spellerberg, M.3    Hamblin, T.J.4    Stevenson, K.5    Capra, J.D.6
  • 141
    • 0025953380 scopus 로고
    • Autoantibodies and autoantigens: A conserved system that may shape a primary immunoglobulin gene pool
    • Stollar BD: Autoantibodies and autoantigens: A conserved system that may shape a primary immunoglobulin gene pool. Mol Immunol 28:1399, 1991
    • (1991) Mol Immunol , vol.28 , pp. 1399
    • Stollar, B.D.1
  • 142
    • 0026555607 scopus 로고
    • Evidence for somatic selection of natural autoantibodies
    • Martin T, Duffy SF, Carson DA, Kipps TJ: Evidence for somatic selection of natural autoantibodies. J Exp Med 175:983, 1992
    • (1992) J Exp Med , vol.175 , pp. 983
    • Martin, T.1    Duffy, S.F.2    Carson, D.A.3    Kipps, T.J.4
  • 144
    • 0024804358 scopus 로고
    • The smaller human VH gene families display remarkably little polymorphism
    • Sanz I, Kelly P, Williams C, Scholl S, Tucker P, Capra JD: The smaller human VH gene families display remarkably little polymorphism. EMBO J 8:3741, 1989
    • (1989) EMBO J , vol.8 , pp. 3741
    • Sanz, I.1    Kelly, P.2    Williams, C.3    Scholl, S.4    Tucker, P.5    Capra, J.D.6
  • 145
    • 0026662676 scopus 로고
    • Genetic mechanisms for dominant VH gene expression. The VHB512 gene
    • Fernandez C: Genetic mechanisms for dominant VH gene expression. The VHB512 gene. J Immunol 149:2328, 1992
    • (1992) J Immunol , vol.149 , pp. 2328
    • Fernandez, C.1
  • 146
    • 0025923889 scopus 로고
    • Clonal persistence of lymphocytes-B in normal mice is determined by variable region-dependent selection
    • Thomas-Vaslin V, Andrade L, Freitas A, Coutinho A: Clonal persistence of lymphocytes-B in normal mice is determined by variable region-dependent selection. Eur J Immunol 21:2239, 1991
    • (1991) Eur J Immunol , vol.21 , pp. 2239
    • Thomas-Vaslin, V.1    Andrade, L.2    Freitas, A.3    Coutinho, A.4
  • 148
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti MHC class I antibody genes
    • Nemazee DA, Burki K: Clonal deletion of B lymphocytes in a transgenic mouse bearing anti MHC class I antibody genes. Nature 337:562, 1989
    • (1989) Nature , vol.337 , pp. 562
    • Nemazee, D.A.1    Burki, K.2
  • 150
    • 0026559216 scopus 로고
    • Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
    • Murakami M, Tsubata T, Okamoto M, Shimizu A, Kumagai S, Imura H, Honjo T: Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357:77, 1992
    • (1992) Nature , vol.357 , pp. 77
    • Murakami, M.1    Tsubata, T.2    Okamoto, M.3    Shimizu, A.4    Kumagai, S.5    Imura, H.6    Honjo, T.7
  • 151
    • 0026481026 scopus 로고
    • Seppuku and autoimmunity
    • Honjo T: Seppuku and autoimmunity. Science 258:591, 1992
    • (1992) Science , vol.258 , pp. 591
    • Honjo, T.1
  • 152
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay D, Saunders T, Camper S, Weigert M: Receptor editing: An approach by autoreactive B cells to escape tolerance. J Exp Med 177:999, 1993
    • (1993) J Exp Med , vol.177 , pp. 999
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 153
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radie MZ, Erikson J, Litwin S, Weigert M: B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 177:1165, 1993
    • (1993) J Exp Med , vol.177 , pp. 1165
    • Radie, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 154
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs SL, Russell DM, Nemazee D: Receptor editing in self-reactive bone marrow B cells. J Exp Med 177:1009, 1993
    • (1993) J Exp Med , vol.177 , pp. 1009
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 158
    • 0024458507 scopus 로고
    • A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes
    • Siminovitch KA, Misener V, Kwong PC, Song QL, Chen PP: A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes. J Clin Invest 84:1675, 1989
    • (1989) J Clin Invest , vol.84 , pp. 1675
    • Siminovitch, K.A.1    Misener, V.2    Kwong, P.C.3    Song, Q.L.4    Chen, P.P.5
  • 159
    • 0023638145 scopus 로고
    • Relationship of human variable region heavy chain germline genes to genes encoding anti-DNA antibodies
    • Dersimonian H, Schwartz RS, Barrett KJ, Stellar BD: Relationship of human variable region heavy chain germline genes to genes encoding anti-DNA antibodies. J Immunol 139:2496, 1987
    • (1987) J Immunol , vol.139 , pp. 2496
    • Dersimonian, H.1    Schwartz, R.S.2    Barrett, K.J.3    Stellar, B.D.4
  • 160
    • 0025905663 scopus 로고
    • Natural autoantibodies: From horror autotoxicus to gnothus seauton
    • Avrameas S: Natural autoantibodies: From horror autotoxicus to gnothus seauton. Immunol Today 12:154, 1991
    • (1991) Immunol Today , vol.12 , pp. 154
    • Avrameas, S.1
  • 161
    • 0026023687 scopus 로고
    • To B or not to B: That is the question
    • Gallagher RB, Osmond DG: To B or not to B: That is the question. Immunol Today 12:1, 1991
    • (1991) Immunol Today , vol.12 , pp. 1
    • Gallagher, R.B.1    Osmond, D.G.2
  • 162
    • 0024310237 scopus 로고
    • Mechanisms of immunologic tolerance
    • MacDonald HR: Mechanisms of immunologic tolerance. Science 246:982, 1989
    • (1989) Science , vol.246 , pp. 982
    • MacDonald, H.R.1
  • 163
    • 0024372111 scopus 로고
    • Acquisition of immunologic self tolerance
    • Schwartz RH: Acquisition of immunologic self tolerance. Cell 57:1073, 1989
    • (1989) Cell , vol.57 , pp. 1073
    • Schwartz, R.H.1
  • 164
    • 0025195540 scopus 로고
    • Tolerance in vitro and in vivo
    • Tomonari K: Tolerance in vitro and in vivo. Immunol Rev 116:139, 1990
    • (1990) Immunol Rev , vol.116 , pp. 139
    • Tomonari, K.1
  • 165
    • 0027251249 scopus 로고
    • Lymphocyte lineage commitment: Instruction versus selection
    • Von Boehmer H, Kisielow P: Lymphocyte lineage commitment: Instruction versus selection. Cell 73:207, 1993
    • (1993) Cell , vol.73 , pp. 207
    • Von Boehmer, H.1    Kisielow, P.2
  • 166
    • 0024512879 scopus 로고
    • Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies
    • Silberstein LE, Litwin S, Carmack CE: Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies. J Exp Med 169:1631, 1989
    • (1989) J Exp Med , vol.169 , pp. 1631
    • Silberstein, L.E.1    Litwin, S.2    Carmack, C.E.3
  • 170
    • 0025249956 scopus 로고
    • Detection of immunoglobulin gene rearrangement in B lymphoid malignancies
    • Deane M, Norton JD: Detection of immunoglobulin gene rearrangement in B lymphoid malignancies. Br J Haematol 74:251, 1990
    • (1990) Br J Haematol , vol.74 , pp. 251
    • Deane, M.1    Norton, J.D.2
  • 171
    • 0025788596 scopus 로고
    • Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction
    • Trainor KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA: Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood 78:192, 1991
    • (1991) Blood , vol.78 , pp. 192
    • Trainor, K.J.1    Brisco, M.J.2    Wan, J.H.3    Neoh, S.4    Grist, S.5    Morley, A.A.6
  • 172
    • 0025212101 scopus 로고
    • Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens
    • McCarthy KP, Sloane JP, Wiedemann LM: Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens. J Clin Pathol 43:429, 1990
    • (1990) J Clin Pathol , vol.43 , pp. 429
    • McCarthy, K.P.1    Sloane, J.P.2    Wiedemann, L.M.3
  • 173
    • 0025767278 scopus 로고
    • An improved method for detection of B-lymphoid clonality by polymerase chain reaction
    • Deane M, McCarthy KP, Wiedemann LM, Norton JD: An improved method for detection of B-lymphoid clonality by polymerase chain reaction. Leukemia 5:726, 1991
    • (1991) Leukemia , vol.5 , pp. 726
    • Deane, M.1    McCarthy, K.P.2    Wiedemann, L.M.3    Norton, J.D.4
  • 175
    • 0025131656 scopus 로고
    • Production of an abnormal mu chain with a shortened VHIV subgroup variable region in a Burkitt's lymphoma cell line
    • Cogne M, Mounir S, Mahdi T, Preud'homme JL, Nau F, Guglielmi P: Production of an abnormal mu chain with a shortened VHIV subgroup variable region in a Burkitt's lymphoma cell line. Mol Immunol 27:929, 1990
    • (1990) Mol Immunol , vol.27 , pp. 929
    • Cogne, M.1    Mounir, S.2    Mahdi, T.3    Preud'homme, J.L.4    Nau, F.5    Guglielmi, P.6
  • 176
    • 0025201139 scopus 로고
    • Detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin hypervariable region specific oligonucleotide probes
    • Jonsson OG, Kitchens RL, Scott FC, Smith RG: Detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin hypervariable region specific oligonucleotide probes. Blood 76:2072, 1990
    • (1990) Blood , vol.76 , pp. 2072
    • Jonsson, O.G.1    Kitchens, R.L.2    Scott, F.C.3    Smith, R.G.4
  • 177
    • 0027343759 scopus 로고
    • Detection of minimal residual disease in ALL
    • Deane M, Hoffbrand AV: Detection of minimal residual disease in ALL. Cancer Treat Res 64:135, 1993
    • (1993) Cancer Treat Res , vol.64 , pp. 135
    • Deane, M.1    Hoffbrand, A.V.2
  • 178
    • 0025807721 scopus 로고
    • The use of the polymerase chain reaction for the detection of minimal residual disease
    • Negrin RS, Blume KG: The use of the polymerase chain reaction for the detection of minimal residual disease. Blood 78:255, 1991
    • (1991) Blood , vol.78 , pp. 255
    • Negrin, R.S.1    Blume, K.G.2
  • 179
    • 0025833889 scopus 로고
    • Analysis of B-lymphoid malignancies using allele-specific polymerase chain reaction: A technique for sequential quantitation of residual disease
    • Billadeau D, Blackstadt M, Greipp P, Kyle RA, Oken MM, Kay N, van Ness B: Analysis of B-lymphoid malignancies using allele-specific polymerase chain reaction: A technique for sequential quantitation of residual disease. Blood 78:3021, 1991
    • (1991) Blood , vol.78 , pp. 3021
    • Billadeau, D.1    Blackstadt, M.2    Greipp, P.3    Kyle, R.A.4    Oken, M.M.5    Kay, N.6    Van Ness, B.7
  • 180
    • 0027528985 scopus 로고
    • Molecular residual disease status at the end of chemotherapy fails to predict subsequent relapse in children with B-lineage acute lymphoblastic leukemia
    • Ito Y, Wasserman R, Galili N, Reichard BA, Shane S, Lange B, Rovera G: Molecular residual disease status at the end of chemotherapy fails to predict subsequent relapse in children with B-lineage acute lymphoblastic leukemia. J Clin Oncol 11:546, 1993
    • (1993) J Clin Oncol , vol.11 , pp. 546
    • Ito, Y.1    Wasserman, R.2    Galili, N.3    Reichard, B.A.4    Shane, S.5    Lange, B.6    Rovera, G.7
  • 182
    • 0025776547 scopus 로고
    • Characterization of immunoglobulin heavy chain genes from an acute lymphocytic leukemia with four rearrangements
    • Carter M, Neale GAM, Kitchingman GR: Characterization of immunoglobulin heavy chain genes from an acute lymphocytic leukemia with four rearrangements. Leukemia 8:668, 1991
    • (1991) Leukemia , vol.8 , pp. 668
    • Carter, M.1    Neale, G.A.M.2    Kitchingman, G.R.3
  • 184
    • 0026628761 scopus 로고
    • Absence of immunoglobulin variable region hypermutation in a large cell lymphoma
    • Stiernholm N, Kuzniar B, Berinstein NL: Absence of immunoglobulin variable region hypermutation in a large cell lymphoma. Blood 80:738, 1992
    • (1992) Blood , vol.80 , pp. 738
    • Stiernholm, N.1    Kuzniar, B.2    Berinstein, N.L.3
  • 185
    • 0027232455 scopus 로고
    • Advancement of multiple myeloma from diagnosis through plateau phase to progression does not involve a new B-cell clone: Evidence from the Ig heavy chain gene
    • Ralph QM, Brisco MJ, Joshua DE, Brown R, Gibson J, Morley AA: Advancement of multiple myeloma from diagnosis through plateau phase to progression does not involve a new B-cell clone: Evidence from the Ig heavy chain gene. Blood 82:202, 1993
    • (1993) Blood , vol.82 , pp. 202
    • Ralph, Q.M.1    Brisco, M.J.2    Joshua, D.E.3    Brown, R.4    Gibson, J.5    Morley, A.A.6
  • 186
    • 0024356882 scopus 로고
    • Immunoglobulin gene expression in small lymphocytic lymphoma with little or no somatic hypermutation
    • Pratt LF, Rassenti L, Larrick J, Robbins B, Banks P, Kipps TJ: Immunoglobulin gene expression in small lymphocytic lymphoma with little or no somatic hypermutation. J Immunol 143:699, 1989
    • (1989) J Immunol , vol.143 , pp. 699
    • Pratt, L.F.1    Rassenti, L.2    Larrick, J.3    Robbins, B.4    Banks, P.5    Kipps, T.J.6
  • 187
    • 0025873890 scopus 로고
    • B cells of chronic lymphatic leukemia express V genes in unmutated form
    • Kuppers R, Gause A, Rajewsky K: B cells of chronic lymphatic leukemia express V genes in unmutated form. Leuk Res 15:487, 1991
    • (1991) Leuk Res , vol.15 , pp. 487
    • Kuppers, R.1    Gause, A.2    Rajewsky, K.3
  • 188
    • 0027462916 scopus 로고
    • Lack of extensive somatic mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia
    • Rassenti LZ, Kipps TJ: Lack of extensive somatic mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia. J Exp Med 177:1039, 1993
    • (1993) J Exp Med , vol.177 , pp. 1039
    • Rassenti, L.Z.1    Kipps, T.J.2
  • 189
    • 0025027662 scopus 로고
    • Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias
    • Deane M, Norton JD: Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias. Eur J Immunol 20:2209, 1990
    • (1990) Eur J Immunol , vol.20 , pp. 2209
    • Deane, M.1    Norton, J.D.2
  • 191
    • 0024406904 scopus 로고
    • Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma
    • Carroll WL, Yu M, Link MP, Korsmeyer SJ: Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma. J Immunol 143:692, 1989
    • (1989) J Immunol , vol.143 , pp. 692
    • Carroll, W.L.1    Yu, M.2    Link, M.P.3    Korsmeyer, S.J.4
  • 192
    • 0023771177 scopus 로고
    • Burkitt's lymphoma cell lines producing truncated-immunoglobulin chains lacking part of the variable region
    • Cogne M, Mounir S, Preud'homme JL, Nau F, Guglielmi P: Burkitt's lymphoma cell lines producing truncated-immunoglobulin chains lacking part of the variable region. Eur J Immunol 18:1485, 1988
    • (1988) Eur J Immunol , vol.18 , pp. 1485
    • Cogne, M.1    Mounir, S.2    Preud'homme, J.L.3    Nau, F.4    Guglielmi, P.5
  • 193
    • 0024348346 scopus 로고
    • Characterisation of immunoglobulin mRNA expression in Burkitt lymphoma cell lines
    • Anker R, Caldwell J, Brokaw J, Pollok BA: Characterisation of immunoglobulin mRNA expression in Burkitt lymphoma cell lines. Int J Cancer 43:930, 1989
    • (1989) Int J Cancer , vol.43 , pp. 930
    • Anker, R.1    Caldwell, J.2    Brokaw, J.3    Pollok, B.A.4
  • 194
    • 0024413178 scopus 로고
    • Immunoglobulin gene alterations in human heavy chain diseases
    • Cogne M, Preud'homme JL, Guglielmi P: Immunoglobulin gene alterations in human heavy chain diseases. Res Immunol 140:487, 1989
    • (1989) Res Immunol , vol.140 , pp. 487
    • Cogne, M.1    Preud'homme, J.L.2    Guglielmi, P.3
  • 195
    • 0023461183 scopus 로고
    • Molecular basis of the cell-surface expression of immunoglobulin m chain without light chain in human B lymphocytes
    • Pollok BA, Anker R, Eldridge P, Hendershot L, Levitt D: Molecular basis of the cell-surface expression of immunoglobulin m chain without light chain in human B lymphocytes. Proc Natl Acad Sci USA 84:9199, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9199
    • Pollok, B.A.1    Anker, R.2    Eldridge, P.3    Hendershot, L.4    Levitt, D.5
  • 196
    • 0019951995 scopus 로고
    • Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma
    • Lenoir GM, Preud'homme JL, Bemheim A, Berger R: Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma. Nature 298:474, 1982
    • (1982) Nature , vol.298 , pp. 474
    • Lenoir, G.M.1    Preud'homme, J.L.2    Bemheim, A.3    Berger, R.4
  • 197
    • 0023677599 scopus 로고
    • Autoantibody-associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin
    • Kipps TJ, Robbins BA, Kuster P, Carson DA: Autoantibody-associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin. Blood 72:422, 1988
    • (1988) Blood , vol.72 , pp. 422
    • Kipps, T.J.1    Robbins, B.A.2    Kuster, P.3    Carson, D.A.4
  • 198
    • 0025357245 scopus 로고
    • CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies
    • Kipps TJ, Robbins BA, Tefferi A, Meisenholder G, Banks PM, Carson DA: CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies. Am J Pathol 136:809, 1990
    • (1990) Am J Pathol , vol.136 , pp. 809
    • Kipps, T.J.1    Robbins, B.A.2    Tefferi, A.3    Meisenholder, G.4    Banks, P.M.5    Carson, D.A.6
  • 201
    • 0026489017 scopus 로고
    • Surface markers, heavy chain sequences and B cell lineages
    • Wortis HH: Surface markers, heavy chain sequences and B cell lineages. Int Rev Immunol 8:235, 1992
    • (1992) Int Rev Immunol , vol.8 , pp. 235
    • Wortis, H.H.1
  • 203
    • 0026759657 scopus 로고
    • Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia
    • Cai J, Humphries C, Richardson A, Tucker PW: Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia. J Exp Med 176:1073, 1992
    • (1992) J Exp Med , vol.176 , pp. 1073
    • Cai, J.1    Humphries, C.2    Richardson, A.3    Tucker, P.W.4
  • 204
    • 0027337036 scopus 로고
    • Molecular analysis of VH and VL regions expressed in IgG bearing chronic lymphocytic leukemia (CLL): Further evidence that CLL is a heterogeneous group of tumors
    • Ebeling SB, Schutte MEM, Logtenberg T: Molecular analysis of VH and VL regions expressed in IgG bearing chronic lymphocytic leukemia (CLL): Further evidence that CLL is a heterogeneous group of tumors. Blood 82:1626, 1993
    • (1993) Blood , vol.82 , pp. 1626
    • Ebeling, S.B.1    Schutte, M.E.M.2    Logtenberg, T.3
  • 205
    • 0027488805 scopus 로고
    • Common clonal origin of chronic lymphocytic leukemia and high grade lymphoma of Richter's syndrome
    • Cherepakhin V, Baird SM, Meisenholder GW, Kipps TJ: Common clonal origin of chronic lymphocytic leukemia and high grade lymphoma of Richter's syndrome. Blood 82:3141, 1993
    • (1993) Blood , vol.82 , pp. 3141
    • Cherepakhin, V.1    Baird, S.M.2    Meisenholder, G.W.3    Kipps, T.J.4
  • 208
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma: Evidence for antigen selection
    • Bahler DW, Levy R: Clonal evolution of a follicular lymphoma: Evidence for antigen selection. Proc Natl Acad Sci USA 86:6770, 1992
    • (1992) Proc Natl Acad Sci USA , vol.86 , pp. 6770
    • Bahler, D.W.1    Levy, R.2
  • 209
    • 0022540466 scopus 로고
    • Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma
    • Cleary ML, Meeker TC, Levy S, Lee E, Trela M, Sklar J, Levy R: Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cell 44:97, 1986
    • (1986) Cell , vol.44 , pp. 97
    • Cleary, M.L.1    Meeker, T.C.2    Levy, S.3    Lee, E.4    Trela, M.5    Sklar, J.6    Levy, R.7
  • 210
    • 0023722177 scopus 로고
    • Mutational hot spots in Ig V region genes of human follicular lymphomas
    • Levy S, Mendel E, Kon S, Avnur Z, Levy R: Mutational hot spots in Ig V region genes of human follicular lymphomas. J Exp Med 168:475, 1988
    • (1988) J Exp Med , vol.168 , pp. 475
    • Levy, S.1    Mendel, E.2    Kon, S.3    Avnur, Z.4    Levy, R.5
  • 212
    • 0023838005 scopus 로고
    • Single cell origin of bigenotypic and biphenotypic B cell proliferations in human follicular lymphomas
    • Cleary M, Galili N, Trela M, Levy R, Sklar J: Single cell origin of bigenotypic and biphenotypic B cell proliferations in human follicular lymphomas. J Exp Med 167:582, 1988
    • (1988) J Exp Med , vol.167 , pp. 582
    • Cleary, M.1    Galili, N.2    Trela, M.3    Levy, R.4    Sklar, J.5
  • 213
    • 0026768775 scopus 로고
    • Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection
    • Zelenetz AD, Chen TT, Levy R: Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med 176:1137, 1992
    • (1992) J Exp Med , vol.176 , pp. 1137
    • Zelenetz, A.D.1    Chen, T.T.2    Levy, R.3
  • 215
  • 216
    • 0025957456 scopus 로고
    • Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell
    • Zelenetz AD, Chen TT, Levy R: Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell. J Exp Med 173:197, 1991
    • (1991) J Exp Med , vol.173 , pp. 197
    • Zelenetz, A.D.1    Chen, T.T.2    Levy, R.3
  • 217
    • 0027222545 scopus 로고
    • A single neoplastic clone in sequential biopsy specimens from a patient with primary gastric mucosa associated lymphoid tissue lymphoma and sjogrens syndrome
    • Diss TC, Peng T, Wotherspoon AC, Pan L, Speight PM, Isaacson PG: A single neoplastic clone in sequential biopsy specimens from a patient with primary gastric mucosa associated lymphoid tissue lymphoma and sjogrens syndrome. N Engl J Med 329:172, 1993
    • (1993) N Engl J Med , vol.329 , pp. 172
    • Diss, T.C.1    Peng, T.2    Wotherspoon, A.C.3    Pan, L.4    Speight, P.M.5    Isaacson, P.G.6
  • 218
    • 0026786675 scopus 로고
    • Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutation
    • Bakkus MH, Heirman C, VanRiet I, VanCamp B, Thielemans K: Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutation. Blood 80:2326, 1992
    • (1992) Blood , vol.80 , pp. 2326
    • Bakkus, M.H.1    Heirman, C.2    VanRiet, I.3    VanCamp, B.4    Thielemans, K.5
  • 219
    • 0025359523 scopus 로고
    • Expression of shared idiotypes by paraproteins from patients with multiple myeloma and monoclonal gammopathy of undetermined significance
    • Berenson JR, Lichtenstein A, Hart S, Palomares, Miller RA: Expression of shared idiotypes by paraproteins from patients with multiple myeloma and monoclonal gammopathy of undetermined significance. Blood 75:2107, 1990
    • (1990) Blood , vol.75 , pp. 2107
    • Berenson, J.R.1    Lichtenstein, A.2    Hart, S.3    Palomares4    Miller, R.A.5
  • 220
    • 0027056009 scopus 로고
    • Multiple independent immunoglobulin class-switch recombinations occurring within the same clone in myeloma
    • Palumbo A, Battaglio S, Astolfi M, Frieri R, Boccadoro M, Pileri A: Multiple independent immunoglobulin class-switch recombinations occurring within the same clone in myeloma. Br J Haematol 82:676, 1992
    • (1992) Br J Haematol , vol.82 , pp. 676
    • Palumbo, A.1    Battaglio, S.2    Astolfi, M.3    Frieri, R.4    Boccadoro, M.5    Pileri, A.6
  • 221
    • 0026687227 scopus 로고
    • Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients
    • Billadeau D, Quam L, Thomas W, Kay N, Greipp P, Kyle R, Oken MM, van Ness B: Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients. Blood 80:1818, 1992
    • (1992) Blood , vol.80 , pp. 1818
    • Billadeau, D.1    Quam, L.2    Thomas, W.3    Kay, N.4    Greipp, P.5    Kyle, R.6    Oken, M.M.7    Van Ness, B.8
  • 222
    • 0027296754 scopus 로고
    • Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to a Cμ sequence in immunoglobulin (IgG)- and IgA-secreting multiple myelomas. Molecular evidence for B lymphocyte involvement in multiple myeloma
    • Corradini P, Boccadoro M, Voena C, Pileri A: Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to a Cμ sequence in immunoglobulin (IgG)- and IgA-secreting multiple myelomas. Molecular evidence for B lymphocyte involvement in multiple myeloma. J Exp Med 178:1091, 1993
    • (1993) J Exp Med , vol.178 , pp. 1091
    • Corradini, P.1    Boccadoro, M.2    Voena, C.3    Pileri, A.4
  • 223
    • 0027257608 scopus 로고
    • The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell
    • Billadeau D, Ahmann G, Greipp P, Van Ness B: The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J Exp Med 178:1023, 1993
    • (1993) J Exp Med , vol.178 , pp. 1023
    • Billadeau, D.1    Ahmann, G.2    Greipp, P.3    Van Ness, B.4
  • 224
    • 0025944664 scopus 로고
    • Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease
    • Cogne M, Preud'homme JL, Bauwens M, Touchard G, Aucouturier P: Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. J Clin Invest 87:2186, 1991
    • (1991) J Clin Invest , vol.87 , pp. 2186
    • Cogne, M.1    Preud'homme, J.L.2    Bauwens, M.3    Touchard, G.4    Aucouturier, P.5
  • 225
    • 0027192374 scopus 로고
    • Exon skipping without splice site mutation accounting for abnormal immunoglobulin chains in non secretory human myeloma
    • Cogne M, Guglielmi P: Exon skipping without splice site mutation accounting for abnormal immunoglobulin chains in non secretory human myeloma. Eur J Immunol 23:1289, 1993
    • (1993) Eur J Immunol , vol.23 , pp. 1289
    • Cogne, M.1    Guglielmi, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.