Soy intake and cancer risk: A review of the in vitro and in vivo data

Nutrition and Cancer

Volumn 21, Issue 2, 1994, Pages 113-131

  Persky, Victoria ^a   Setchell, Kenneth D R ^b   Barnes, Stephen ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b CHILDREN S HOSPITAL AND MEDICAL CENTER   (United States)

^c Departments of Pharmacology and Biochemistry   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; ISOFLAVONE DERIVATIVE; PROTEIN TYROSINE KINASE;

BREAST CANCER; CANCER PREVENTION; CANCER RISK; CARCINOGENESIS; COLON CANCER; DIET; ESTROGEN ACTIVITY; PROSTATE CANCER; REVIEW; SOYBEAN;

ANIMAL; GENISTEIN; HUMAN; ISOFLAVONES; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; PROTEIN-TYROSINE KINASE; RISK FACTORS; SIGNAL TRANSDUCTION; SOYBEANS; TUMOR CELLS, CULTURED;

EID: 0028216956     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635589409514310     Document Type: Review

References (112)

1. Saio, K: “Dietary Pattern and Soybean Processing in Japan Today.” Trop Agrie Res Serv 17, 153-161, 1984.
2. Setchell, KDR, Borriello, SP, Hulme, P, Kirk, DN, and Axelson, M: “Nonsteroidal Estrogens of Dietary Origin: Possible Roles in Hormone-Dependent Disease.” Am J Clin Nutr 40, 569-578, 1984.
3. Bames, S, Grubbs, C, Setchell, KDR, and Carlson, J: “Soybeans Inhibit Mammary Tumors in Models of Breast Cancer. In Mutagens and Carcinogens in the Diet, MW Pariza, H-U Aeschbacher, JS Felton, and S Sato (eds). New York: Wiley-Liss, 1990, pp 239-253.
4. Adlercreutz, H “Western Diet and Western Diseases: Some Hormonal and Biochemical Mechanisms and Associations.” Scand J Clin Lab Invest 50, 201, 3-23, 1990.
5. Messina, M, and Bames, S: “The Role of Soy Products in Reducing Risk of Cancer.” JNCI 83, 541-546, 1991.
6. Jones, AE, Price, KR, and Fenwick, GR: “Development and Application of a High-Performance Liquid Chromatographic Method for the Analysis of Phytoestrogens.” J Sci Food Agrie 46, 357-364, 1989.
7. Murphy, PA: “Phytoestrogen Content of Processed Soybean Products.” Food Tech 1, 60-64, 1982.
8. Coward, L, Bames, NC, Setchell, KDR, and Bames, S: “Genistein and Daidzein, and Their ß-Glycoside Conjugates: Anti-Tumor Isoflavones in Soybean Foods of the American and Asian Diets.” J Agrie Food Sci 41, 1961-1967, 1993.
9. Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Wantanabe, S-I, et al.: “Genistein, a Specific Inhibitor of Tyrosine-Specific Protein Kinase.” J Biol Chem 262, 5592-5595, 1987.
10. Akiyama, T, and Ogawara, H: “Use and Specificity of Genistein as Inhibitor of Protein-Tyrosine Kinases.” Methods Enzymol 201, 362-370, 1991.
11. Farmakalidis, E, Hathcock, JN, and Murphy, PA: “Oestrogenic Potency of Genistin and Daidzin in Mice.” Food Chem Toxicol 23, 741-745, 1985.
12. Kitts, DD, Krishnamurti, CR, and Kitts, WD: “Uterine Weight Changes and 3H-Uridine Uptake in Rats Treated With Phytoestrogens.” Can J Animal Sci 60, 531-534, 1980.
13. Somjen, D, and Kaye, AM. “Specificities in the Synthesis of a Cytoplasmic Estrogen-Induced Uterine Protein.” Mol Cell Endocrinol 4, 353-358, 1976.
14. Mayr, U, Butsch, A, and Schneider, S: “Validation of Two In Vitro Test Systems for Estrogenic Activities With Zearalenone, Phytoestrogens and Cereal Extracts.” Toxicology 74, 135-149, 1992.
15. Welshons, WV, Rottinghaus, E, Nonneman, DJ, Dolan-Timpe, M, and Ross PF: “A Sensitive Bioassay for Detection of Dietary Estrogens in Animal Feeds.” J Vet Diagn Invest 2, 268-273, 1990.
16. Newsome, FE, and Kitts, WD: “Action of Phyto-Estrogens Coumestrol and Genistein on Cytosolic and Nuclear Oestradiol-17ß Receptors in Immature Rat Uterus.” Animal Reprod Sci 3, 233-245, 1980.
17. Folman, Y, and Pope, GS: “Effect of Norethisterone Acetate, Dimethylstilbesterol, Genistein and Coumestrol on Uptake of [3H]Oestradiol by Uterus, Vagina and Skeletal Muscle of Immature Mice.” J Endocrinol 44, 213-218, 1969.
18. Markiewicz, L, Garey, J, Adlercreutz, H, and Gurpide, E: “In Vitro Bioassays of Non-Steroidal Phytoestrogens.” J Steroid Biochem Mol Biol 45, 399-405, 1993.
19. Mathieson, RA, and Kitts, WD: “Binding of Phyto-Oestrogen and Oestradiol-17ß by Cytoplasmic Receptors in the Pituitary Gland and Hypothalamus of the Ewe.” J Endocrinol 85, 317-325, 1980.
20. Shutt, DA, and Cox, RI: “Steroid and Phyto-Oestrogen Binding to Sheep Uterine Receptors In Vitro.” J Endocrinol 52, 299-310, 1972.
21. Martin, PM, Horwitz, KB, Ryan, DS, and McGuire, WL: “Phytoestrogen Interaction With Estrogen Receptors in Human Breast Cancer Cells.” Endocrinology 103, 1860-1867, 1978.
22. Verdeal, K, Brown, RR, Richardson, T, and Ryan, DS: “Affinity of Phytoestrogens for Estradiol-Binding Proteins and Effect of Coumestrol on Growth of 7, 12-Dimethylbenz(a)anthracene-Induced Rat Mammary Tumors.” JNCI 64, 285-290, 1980.
23. Folman, Y, and Pope, GS: “The Interaction in the Immature Mouse of Potent Oestrogens With Coumestrol, Genistein and Other Utero-Vaginotrophic Compounds of Low Potency.” J Endocrinol 34, 215-225, 1966.
24. Clark, JH, Paszko, A, and Peck, EJ: “Nuclear Binding and Retention of the Receptor Estrogen Complex: Relation to the Agonistic and Antagonistic Properties of Estradiol.” Endocrinology 100, 91-96, 1977.
25. Katzenellenbogen, JA, Ferguson, ER, and Lan, NC: “Fundamental Differences in the Action of Estrogens and Antiestrogens on the Uterus: Comparison Between Compounds With Similar Duration of Action.” Endocrinology 100, 1252-1259, 1977.
26. Folman, Y, and Pope, GS. “Effect of Norethisterone Acetate, Dimethylstilbesterol, Genistein and Coumestrol on Uptake of [3H]Oestradiol by Uterus, Vagina and Skeletal Muscle of Immature Mice.” J Endocrinol 44, 213-218, 1969.
27. Shutt, DA: “Interaction of Genistein With Oestradiol in the Reproductive Tract of the Ovariectomized Mouse.” J Endocrinol 37, 231-232, 1967.
28. Cassidy, A, Bingham, S, Carlson J, and Setchell, K: “Biological Effects of Plant Estrogens in Premenopausal Women” (abstr). Fed Am Soc Exp Biol 7 A866, 1993.
29. Mousavi, Y, and Adlercretuz, H: “Genistein is an Effective Stimulator of Sex Hormone-Binding Globulin Production in Hepatocarcinoma Human Liver Cancer Cells and Suppresses Proliferation of These Cells in Culture.” Steroids 58, 301-304, 1993.
30. Kuriu, A, Ikeda, H, Kanakura, Y, Griffen, JD, Druker, B, et al.: “Proliferation of Human Myeloid Leukemia Cell Line Associated With the Tyrosine-Phosphorylation and Activation of the Proto-Oncogene c-kit Product.” Blood 78, 2834-2840, 1991.
31. Cunningham, B.D.M., Threadgill, M.D., Groundwater, P.W., Dale, I.L., and Hickman, J.A.: “Synthesis and Biological Evaluation of a Series of Flavones Designed as Inhibitors of Protein Tyrosine Kinases.” Anticancer Drug Des 7, 365-384, 1992.
32. Okura, A, Arakawa, H, Oka, H, Yoshinai, T, and Monden, Y: “Effect of Genistein on Topoisomerase Activity and on the Growth of [val 12]Ha-Ras-Transformed NIH 3T3 Cells.” Biochem Biophys Res Commun 157, 183-189, 1988.
33. Markovits, J, Linassier, C, Fosse, P, Couprie, J, Pierre, J, et al.: “Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II.” Cancer Res 49, 5111-5117, 1989.
34. Linassier, C, Pierre, M, Le Peco, J-B, and Pierre, J: “Mechanisms of Action in NIH-3T3 Cells of Genistein, an Inhibitor of EGF-Receptor Tyrosine Kinase Activity.” Biochem Pharmacol 39, 187-193, 1990.
35. Makishima, M, Honma, Y, Hozumi, M, Sampi, K, Hatton, M, et al.: “Effects of Inhibitors of Protein Tyrosine Kinase Activity and/or Phosphatidylinositol Turnover on Differentiation of Some Human Myelomonocytic Leukemia Cells.” Leukemia Res 15, 701-708, 1991.
36. Peterson, G, and Barnes, S: “Genistein Inhibition of the Growth of Human Breast Cancer Cells: Independence From Estrogen Receptors and the Multi-Drug Resistance Gene.” Biochem Biophys Res Commun 179, 661-667, 1991.
37. Clark, J, Chu, M, and Celebresi, P: “Growth Inhibition of Colon Cells by Genistein and Suramin” (abstr). Proc Am Assoc Cancer Res 30, 559, 1989.
38. Honma, Y, Okabe-Kado, J, Kasukabe, T, Hozumi, M, and Umezawa K: “Inhibition of abl Oncogene Tyrosine Kinase Induces Erythroid Differentiation of Human Myelogenous Leukemia K562 Cells.” Jpn J Cancer Res 81, 1132-1136, 1990.
39. Constantinou, A, Kiguchi, K, and Huberman, E: “Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K562 Leukemia Cells by Genistein.” Cancer Res 50, 2618-2624, 1990.
40. Watanabe, T, Kondo, K, and Oishi, M: “Induction of In Vitro Differentiation of Mouse Erythroleukemia Cells by Genistein, an Inhibitor of Tyrosine Protein Kinases.” Cancer Res 51, 764-768, 1991.
41. Watanabe, T, Shiraishi, T, Sasaki, H, and Oishi, M: “Inhibitors for Protein-Tyrosine Kinases, ST638 and Genistein, Induce Differentiation of Mouse Erythroleukemia Cells in a Synergistic Manner.” Exp Cell Res 183, 335-342, 1989.
42. Konda, K, Tsuneizumi, K, Watanabe, T, and Oishi, M: “Induction of In Vitro Differentiation of Mouse Embryonal Carcinoma (F9) Cells by Inhibitors of Topoisomerases.” Cancer Res 51, 5398-5404, 1991.
43. Peterson, G, and Barnes, S: “Genistein and Biochanin A Inhibit the Growth of Human Prostate Cancer Cells But Not Epidermal Growth Factor Receptor Tyrosine Autophosphorylation.” Prostate 22, 335-345, 1993.
44. Nishibe, S, Wabi, M, Rhee, SG, and Carpenter, G: “Tyrosine Phosphorylation of Phospholipase C-II In Vitro by the Epidermial Growth Factor Receptor.” J Biol Chem 264, 10335-10338, 1989.
45. Cochet, C, Filhoi, C, Payrastre, B, Hunter, T, and Gill, GM: “Interaction Between the Epidermal Growth Factor Receptor and Phosphoinositol Kinases.” J Biol Chem 266, 637-644, 1991.
46. Nishida, N, Hosh, M, Migata, Y, Sakai, H, Kadowaki, T, et al.: “Tyrosine Phosphorylation by the Epidermal Growth Factor Receptor Kinase Induces Functional Alterations in Microtubule-Associated Protein 2.” J Biol Chem 262, 16200-16204, 1987.
47. Dayani, N, McNaught, R, Shenolikar, S, and Smith, RG: “Receptor Interconversion Model of Hormone Action.2. Requirement of Both Kinase and Phosphatase Activities for Confering Estrogen Binding Activity in the Estrogen Receptor.” Biochemistry 29, 2691-2698, 1990.
48. Fotsis, T, Pepper, M, Adlercreutz, H, Gleischmann, G, Hase, T, et al.: “Genistein, a Dietary-Derived Inhibitor of In Vitro Angiogenesis.” Proc Natl Acad Sci USA 90, 2690-2694, 1993.
49. Grant, G: “Anti-Nutritional Effects of Soyabean: A Review.” Prog Food Nutr Sci 13, 317-349, 1989.
50. Troll, W, Wiesner, R, Shellabarger, CJ, Holtzman, S, and Stone, JP: “Soybean Diet Lowers Breast Tumor Incidence in Irradiated Rats.” Carcinogenesis 1, 469-472, 1980.
51. Hawrylewicz, EJ, Huang, HH, and Blair, WH: “Dietary Soyabean Isolate and Methionine Supplementation Affect Mammary Tumor Progression in Rats.” J Nutr 121, 1693-1698, 1991.
52. Baggott, JE, Ha, T, Vaughn, WH, Juliana, MM, Hardin, JM, et al.: “Effect of Miso (Japanese Soybean Paste) and NaCl on DMBA-Induced Rat Mammary Tumors.” Nutr Cancer 14, 103-109, 1990.
53. Carroll, KK: “Experimental Evidence of Dietary Factors and Hormone-Dependent Cancers.” Cancer Res 35, 3374-3383, 1975.
54. Hsueh, AM, and Park, H-S: “Quality of Dietary Protein and Chemical Carcinogenesis in Rats” (abstr). Int News Fats Oil Related Materials 1, 303, 1990.
55. Gridley, DS, Kettering, JD, Slater, JM, and Nutter, RL: “Modification of Spontaneous Mammary Tumors in Mice Fed Different Sources of Protein, Fat, and Carbohydrate.” Cancer Lett 19, 133-146, 1983.
56. Clinton, SK, Destree, RJ, Anderson, DR, Truex, RC, Imrey, PB, et al.: “Dimethylhydrazine Induced Intestinal Cancer in Rats Fed Beef or Soybean Protein.” Nutr Rep Inter 20, 335-342, 1979.
57. Reddy, BS, Narisawa, T, and Weisburger, JH: “Effect of a Diet With High Levels of Protein and Fat on Colon Carcinogenesis in F344 Rats Treated With 1, 2-Dimethylhydrazine.” JNCI 57, 567-569, 1976.
58. Fitzsimons, JTR, Orson, NV, and El-Aaser, AA: “Effects of Soyabean and Ascorbic Acid on Experimental Carcinogenesis.” Comp Biochem Physiol 93A, 285-290, 1989.
59. Mokhtar, NM, El-Asser, AA, El-Bolkainy, MN, Ibrahim, HA, El-Din, B, et al.: “Effect of Soybean Feeding on Experimental Carcinogenesis—III. Carcinogenicity of Nitrite and Dibutylamine in Mice: A Histopathological Study.” Fur J Clin Oncol 24, 403-411, 1988.
60. Becker, FF: “Inhibition of Spontaneous Hepatocarcinogenesis in C3H/HeN Mice by Edi Pro A, an Isolated Soy Protein.” Carcinogenesis 2, 1213-1214, 1981.
61. Ito, A, Watanabe, H, and Basaran, N: “Effects of Soy Products in Reducing Risk of Spontaneous and Neutron-Induced Liver Tumors in Mice.” Int J Oncol 2, 773-776, 1993.
62. Hendrich, S, and Lee, K-W: “Antioxidant and Anticarcinogenic Effect of Soybean Isoflavones” (abstr). Int News Fats Oil Related Materials 4, 529, 1993.
63. Rogers, AE, Lenhart, G, and Morrison, G: “Influence of Dietary Lipotrope and Lipid Content on Aflatoxin B[, ¿V-2-Fluorenylacetamide, and 1, 2-Dimethylhydrazine Carcinogenesis in Rats.” Cancer Res 40, 2802-2807, 1980.
64. Troll, W, Wiesner, R, Belman, S, and Shellabarger, CJ: “Inhibition of Carcinogenesis by Feeding Diets Containing Soybeans” (abstr). Proc Am Assoc Cancer Res 20, 265, 1979.
65. Sharma, OP, Adlercreutz, H, Strandberg, JD, Zirkin, BR, Coffey, DS, et al.: “Soy of Dietary Source Plays a Preventive Role Against the Pathogenesis of Prostatitis in Rats.” J Steroid Biochem Mol Biol 43, 557-564, 1992.
66. Makela, S, Pylkkanen, L, Santti, R, and Adlercreutz, H: “Role of Plant Estrogens in Normal and Estrogen-Related Altered Growth of the Mouse Prostate.” In Institute of Technology Effects of Food on the Immune and Hormonal Systems. Schwerzenbach, Switzerland: University of Zurich and Swiss Federal Institute of Technology, 1991, pp 135-139.
67. Troll, W, Belman, S, Wiesner RS, and Shellabarger, CJ: “Protease Action in Carcinogenesis.” In Biological Functions of Proteases, H Holzer and H Tschesche (eds). New York: Springer-Verlag, 1979, pp 165-170.
68. Bowen, R, Barnes, S, and Wei, H: “Antipromotional Effect of the Soybean Isoflavone Genistein” (abstr). Proc Am Assoc Cancer Res 34, 555, 1993.
69. Wei, H, Wei, L, Frenkel, K, Bowen, R, and Bames, S: “Inhibition of Tumor Promoter-Induced Hydrogen Peroxide Formation In Vitro and In Vivo by Genistein.” Nutr Cancer 20, 1-12, 1993.
70. Kim, J-P, Park, J-G, Lee, M-D, Han, M-D, Park, S-T, et al.: “Co-Carcinogenic Effects of Several Korean Foods on Gastric Cancer Induced by Ar-Methyl-A'1-Nitro-A,-Nitrosoguanidine in Rats.” Jpn J Surg 15, 427-437, 1985.
71. Watanabe, H, Okamoto, T, Takahashi, T, Ogundigie, PO, and Ito, A: “The Effects of Sodium Chloride, Miso, or Ethanol on Development of Intestinal Metaplasia after X-Irradiation of the Rat Glandular Stomach.” Jpn J Cancer Res 83, 1267-1272, 1992.
72. Hirohata, T, Shigematsu, T, Nomura, AMY, Nomura, Y, Horie, A, et al.: “Occurrence of Breast Cancer in Relation to Diet and Reproductive History: A Case-Control Study in Fukuoka, Japan.” Natl Cancer Inst Monogr 69, 187-190, 1985.
73. Nomura, A, Henderson, BE, and Lee J: “Breast Cancer and Diet Among the Japanese in Hawaii.” Am J Clin Nutr 31, 2020-2025, 1978.
74. Hirayama, T: “A Large Scale Cohort Study on Cancer Risks by Diet—With Special Reference to the Risk Reducing Effects of Green-Yellow Vegetable Consumption.” In Diet, Nutrition and Cancer, Y Hayashi et al. (eds). Utrecht, The Netherlands: Tokyo/VNU Sci Press, 1986, pp 41-53.
75. Lee, HP, Gourley, L, Duffy, SW, Esteve, J, and Day, NE: “Dietary Effects on Breast-Cancer Risk in Singapore.” Lancet 337, 1197-1200, 1991.
76. Hirayama, T: “Epidemiology of Prostate Cancer With Special Reference to the Role of Diet.” Natl Cancer Inst Monogr 53, 149-155, 1979.
77. Oishi, K, Okada, K, Yoshida, O, Yamabe H, Ohno, Y, et al.: “A Case-Control Study of Prostatic Cancer With Reference to Dietary Habits.” Prostate 12, 179-190, 1988.
78. Severson, RK, Nomura, AMY, Grove, JS, and Stemmermann, GN: “A Prospective Study of Demographics, Diet and Prostate Cancer Among Men of Japanese Ancestry in Hawaii.” Cancer Res 49, 1857-1860, 1989.
79. McKeown-Eyssen, GE, and Bright-See, E: “Dietary Factors in Colon Cancer: International Relationships.” Nutr Cancer 6, 160-170, 1984.
80. Haenszel, W, Berg, JW, Segi, M, Kurihara, M, and Locke, FB: “Large-Bowel Cancer in Hawaiian Japanese.” JNCI 51, 1765-1779, 1973.
81. Tajima, K, and Tominaga, S: “Dietary Habits and Gastro-Intestinal Cancers: A Comparative Case-Control Study of Stomach and Large Intestinal Cancers in Nagoya, Japan.” Jpn J Cancer Res (Gann)76, 705-716, 1985.
82. Poole, C: A Case-Control Study of Diet and Colon Cancer (Dissertation). Boston, MA: Harvard School of Public Health, 1989.
83. Hu, J, Liu, Y, Yu, Y, Zhao, T, Liu, S, et al.: “Diet and Cancer of the Colon and Rectum: A Case-Control Study in China.” Int J Epidemiol 20, 362-367, 1991.
84. Watanabe, Y, Tada, M, Kawamoto, K, Uozumi, G, Kajiwara, Y, et al.: “A Case-Control Study of Cancer of the Rectum and the Colon.” Nippon Shokakibyo Gakkai Zasshi 81, 185-194, 1984.
85. Wu-Williams, AH, Dai, XD, Blot, W, Xu, ZY, Sun, XW, et al.: “Lung Cancer Among Women in North-East China.” Br J Cancer 62, 982-987, 1990.
86. Koo, LC: “Dietary Habits and Lung Cancer Risk Among Chinese Females in Hong Kong Who Never Smoked.” Nutr Cancer 11, 155-172, 1988.
87. Swanson, CA, Mao, BL, Li, JY, Lubin, JH, Yao, SX, et al.: “Dietary Determinants of Lung-Cancer Risk: Results From a Case-Control Study in Yunnan Province, China.” Int J Cancer 50, 876-880, 1992.
88. Ershow, AG, Gao, YI, Zheng, W, and Blot, WJ: “Diet Effects on Lung Cancer Risk of Chinese Men and Women” (abstr). FASEB J 4, A1041, 1990.
89. Hirayama, T: “Epidemiology of Stomach Cancer.” GANN Monogr Cancer Res 11, 3-19, 1971.
90. Nagai, M, Hashimoto, T, Yanagawa, H, Yokoyama, H, and Minowa, M. “Relationship of Diet to the Incidence of Esophageal and Stomach Cancer in Japan.” Nutr Cancer 3, 257-268, 1982.
91. Nomura, A, Grove, JS, Stemmermann, GN, and Severson, RK: “A Prospective Study of Stomach Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption.” Cancer Res 50, 627-631, 1990.
92. Hirayama, T: “Epidemiology of Stomach Cancer in Japan.” Jpn J Clin Oncol 14, 159-168, 1984.
93. Hirayama, T: “Relationship of Soybean Paste Soup Intake to Gastric Cancer Risk.” Nutr Cancer 3, 223-233, 1982.
94. Hoshiyama, Y, and Sasaba, T: “A Case-Control Study of Single and Multiple Stomach Cancers in Saitama Prefecture, Japan.” Jpn J Cancer Res 83, 937-943, 1992.
95. Hoshiyama, Y, and Sasaba, T: “A Case-Control Study of Stomach Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption in Saitama Prefecture, Japan.” Cancer Causes Control 3, 441-448, 1992.
96. Hu, J, Zhang, S, Jia, E, Wang, Q, Liu, S, et al.: “Diet and Cancer of the Stomach: A Case-Control Study in China.” Int J Cancer 41, 331-335, 1988.
97. Crane, PS, Rhee, SU, and Seel, DJ: “Experience With 1, 079 Cases on Cancer of the Stomach Seen in Korea From 1962 to 1968.” Am J Surg 120, 747-751, 1970.
98. Segi, M, Fukushima, I, Fujisaku, S, Kurihara, M, Saito, S, et al.: “An Epidemiological Study on Cancer in Japan.” GANN 48 1-63, 1957.
99. You, WC, Blot, WJ, Chang, YS, Ershow, AG, Yang, ZT, et al.: “Diet and High Risk of Stomach Cancer in Shandong, China.” Cancer Res 48, 3518-3523, 1988.
100. Haenszel, W, Kurihara, M, Segi, M, and Lee, RKC “Stomach Cancer Among Japanese in Hawaii.” JNCI 49, 969-988, 1972.
101. Yingnan, Y, and Songlin, Y: “A Study of the Etiological Factors in Gastric Cancer in Fuzhou City.” Chin J Epidemiol 7, 48-50, 1986.
102. Kui-Xiong, S, Zhi, T, Xin-Yao, Q, and Gui-Se, J: “Epidemiology of Gastric Cancer in China.” First Shanghai Int Symp Gastrointest Cancers, Shanghai, China 1988, pp 34—44.
103. Sasaki, R, Aoki, K, and Takeda, S: “Contribution of Dietary Habits to Esophageal Cancer in Japan.” In Recent Progress in Research on Nutrition and Cancer. New York: Wiley-Liss, 1990, pp 83-90.
104. Kato, K, Akai, S, Tominaga, S, and Kato, I: “A Case-Control Study of Biliary Tract Cancer in Niigata Prefecture, Japan.” Jpn J Cancer Res 80, 932-938, 1989.
105. Parkin, DM, Srivatanakul, P, Khlat, M, Chenvidhya, D, Chotiwan, P, et al.: “Liver Cancer in Thailand. I. A Case-Control Study of Cholangiocarcinoma.” Int J Cancer 48, 323-328, 1991.
106. Srivatanakul, P, Parkin, DM, Khlat, M, Chenvidhya, D, Chottwan, P, et al.: “Liver Cancer in Thailand. II. A Case-Control Study of Hepatocellular Carcinoma.” Int J Cancer 48, 329-332, 1991.
107. Hirayama, T: “Epidemiology of Pancreatic Cancer in Japan.” Jpn J Clin Oncol 19, 208-215, 1989.
108. Hirayama, T: “Life-Style and Cancer: From Epidemiological Evidence to Public Behavior Change to Mortality Reduction of Target Cancers.” J Natl Cancer Inst Monogr 12, 65-74, 1992.
109. Carroll, KK: “Review of Clinical Studies on Cholesterol-Lowering Response to Soy Protein.” J Am Diet Assoc 91, 820-827, 1991.
110. Kalu, DN, Masoro, EJ, Yu, BP, Hardin, RR, and Hollis, BW: “Modulation of Age-Related Hyperparathyroidism and Senile Bone Loss in Fischer Rats by Soy Protein and Food Restriction.” Endocrinology 122, 1847-1854, 1988.
111. Breslau, NA, Brinkley, L, Hill, KD, and Pak, CYC “Relationship of Animal Protein-Rich Diet to Kidney Stone Formation and Calcium Metabolism.” J Clin Endocrinol Metab 66, 140-146, 1988.
112. Brandi, ML: “Flavonoids: Biochemical Effects and Therapeutic Applications.” Bone Miner 19, S3-S14, 1992.