Distinct receptors and signaling pathways in α-thrombin- and thrombin receptor peptide-induced vascular contractions

Circulation Research

Volumn 74, Issue 5, 1994, Pages 930-936

  Tesfamariam, Belay ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

active site; contraction; coronary arteries; hirudin; signal transduction; tethered ligand receptor; thrombin

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE; RECEPTOR SUBTYPE; THROMBIN;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; VASOCONSTRICTION; VASODILATATION;

EID: 0028214577     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.74.5.930     Document Type: Article

References (26)

1. Garland C, Bevan JA. Alpha adrenoceptor antagonists selectively reduce thrombin-stimulated contraction in rabbit arteries. J Pharmacol Exp Ther. 1986;238:947-953.
2. Haver VM, Namm DH. Generation of a vasoactive substance in human plasma during coagulation: evidence of thrombin-induced contraction of rabbit aorta and dog coronary artery. Blood Vessels. 1983;20:92-98.
3. White RP, Chapleau CE, Dugdale M, Robertson JT. Cerebral arterial contractions induced by human and bovine thrombin. Stroke. 1980;11:363-368.
4. De Mey JG, Vanhoutte PM. Endothelium-dependent inhibitory effects of acetylcholine, adenosine, thrombin and arachidonic acid in the canine femoral artery. J Pharmacol Exp Ther. 1982;222: 166-173.
5. Gebremedhin D, Ballagi-Pordany G, Hadhazy P, Magyar K, Machovich R. Species specificity of thrombin-induced changes in vascular tone. Eur J Pharmacol. 1986;132:71-74.
6. Tesfamariam B, Allen GT, Normandin D, Antonaccio MJ. Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-dependent relaxations. Am J Physiol. 1993; 265:H1744-H1749.
7. Rapoport RM, Draznin MB, Murad F. Mechanisms of adenosine triphosphate, thrombin, and trypsin-induced relaxation of rat thoracic aorta. Circ Res. 1984;55:468-479.
8. Ku DD, Zaleski JK. Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. J Cardiovasc Pharmacol. 1993;22:609-616.
9. Vu T-KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
10. Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ. Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem. 1991;60:653-688.
11. Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615-649.
12. Vassalo RR Jr, Kieber-Emmons T, Cichowski K, Brass LF. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem. 1991;267:6081-6085.
13. Huang R, Sorisky A, Church WA, Simons ER, Rittenhouse SE. "Thrombin" receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J Biol Chem. 1991;266: 18435-18438.
14. 2Cl, a selective affinity for thrombin. Thromb Res. 1979;14:969-973.
15. Fenton JW, Villanueva GB, Ofosu FA, Maraganore JM. Thrombin inhibition by hirudin: how hirudin inhibits thrombin. Haemostasis. 1991;21(suppl 1):27-31.
16. Seiler SM, Goldberg HJ, Michel IM, Hunt JT, Zavoico GB. Multiple pathways of thrombin-induced platelet activation differentiated by desensitization and a thrombin exosite inhibitor. Biochem Biophys Res Commun. 1991;181:636-643.
17. Misra RN, Brown BR, Sher PM, Patel MM, Hall SE, Han WC, Barrish JC, Floyd DM, Sprague PW, Morrison RA, Ridgewell RE, White RE, DiDonato GC, Harris DN, Hedberg A, Schumacher WA, Webb ML, Ogletree ML. Thromboxane receptor antagonist BMS-180291: a new pre-clinical lead. Biomed Chem Lett. 1992;2: 73-76.
18. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
19. Simonet S, Bonhomme E, Laubie M, Thurieau C, Fauchere J-L, Verbeuren TJ. Venous and arterial cells respond differently to thrombin and its endogenous receptor agonist. Eur J Pharmacol. 1992;216:135-137.
20. Antonaccio MJ, Normandin D, Serafino R, Moreland S. Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle. J Pharmacol Exp Ther. 1993;266:125-132.
21. Webb ML, Taylor DS, Molloy CJ. Effects of thrombin receptor activating peptide on phosphoinositide hydrolysis and protein kinase C activation in cultured rat aortic smooth muscle cells: evidence for "tethered ligand" activation of smooth muscle cell thrombin receptors. Biochem Pharmacol. 1993;45:1577-1582.
22. Brass LF. Homologous desensitization of HEL cell thrombin receptors. J Biol Chem. 1992;267:6044-6050.
23. Huang EM, Detwiler TC. Thrombin-induced phosphoinosite hydrolysis in platelets: receptor occupancy and desensitization. Biochem J. 1987;242:11-18.
24. Muramatsu I, Laniyonu A, Moore GJ, Hollenberg MD. Vascular actions of thrombin receptor peptide. Can J Physiol Pharmacol. 1992;70:996-1003.
25. Hoxie JA, Ahuja M, Belmonte E, Pizarro S, Parton R, Brass LF. Internalization and recycling of activated thrombin receptor. J Biol Chem. 1993;268:13756-13763.
26. Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells: relation to signaling. J Biol Chem. 1993;268:9780-9786.