Radiosensitivity in ataxia-telangiectasia: Anomalies in radiation-induced cell cycle delay

International Journal of Radiation Biology

Volumn 65, Issue 2, 1994, Pages 175-184

  Beamish, H ^a   Lavin, M F ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE;

ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIVITY;

ATAXIA TELANGIECTASIA; CELL CYCLE; CELLS, CULTURED; DNA DAMAGE; GAMMA RAYS; HUMAN; IN VITRO; SUPPORT, NON-U.S. GOV'T;

EID: 0028213350     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553009414550211     Document Type: Article

References (46)

1. Analysis of flow cytometric data of irradiated cell populations
2. Comparison of γ-irradiation-induced accumulation of ataxia-telangiectasia and control cells in G2 phase
3. Identification of ataxia-telangiectasia heterozygotes; a cancer prone population
4. Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delays
5. Radiosensitivity in ataxia-telangiectasia
6. Microtubule dynamics during the cell cycle. The effects of taxol and nocodazole on the microtubule system of Pt K2 cells at different stages of the mitotic cycle
7. Genetics of human cell lines III incorporation of 5-bromo- and 5-lododeoxyuridine into the DNA of human cells and its effect on radiation sensitivity
8. Ataxiatelangiectasia
9. The effects of ionizing radiation on cell cycle progression in ataxia-telangiectasia
10. Speculations on the ataxia-telangiectasia defect
11. Effect of ionizing radiation on DNA synthesis in ataxia-telangiectasia cells
12. Perturbations of cell cycle progression in gamma-irradiated ataxia-telangiectasia and Huntington's disease cells detected by DNA flow cytometric analysis
13. Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells
14. Participation of p53 protein in the cellular response to DNA damage
15. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
16. Ionizing radiation and UV induce p53 protein in ataxia-telangiectasia cells by different pathways
17. Wild-type p53 is a cell cycle checkpoint determinant following irradiation
18. p53, guardian of the genome
19. Enhanced levels of radiation-induced G2 phase delay in ataxia-telangiectasia heterozygotes
20. Delay of cell cycle progression after X-irradiation of synchronized populations of human cells (NHIK 3025) in culture
21. Synergistic effect of v-myc and H-ras on radioresistance
22. UV irradiation stimulates levels of p53 cellular tumour antigen in nontransformed mouse cells
23. Lack of correlation between hypersensitivity to cell killing and impaired inhibition of DNA synthesis in ataxia-telangiectasia fibroblasts treated with 4-nitroquinoline 1-oxide
24. Hypersensitivity to cell killing and faulty repair of 1-β-d-arabino-furanosylcytosine-detectable sites in human (ataxia-telangiectasia) fibroblasts treated with 4-nitroquinoline 1-oxide
25. Radiation reaction in ataxia-telangiectasia
26. Creative blocks, cell-cycle checkpoints and feedback controls
27. Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia-telangiectasia (AT) fibroblasts
28. Comparison of kinetics of X-ray-induced cell killing in normal, ataxia-telangiectasia and hereditary retinoblastoma fibroblasts
29. Structural changes in chromatin as the basis for radiosensitivity in ataxia-telangiectasia
30. Radiosensitivity in ataxia-telangiectasia. A new explanation
31. The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia
32. Defective excision repair of gamma-ray-damaged DNA in human (ataxia-telangiectasia) fibroblasts
33. Synchronization of HeLa cell cultures by inhibition of DNA polymerase α with aphidicolin
34. The wee-1 protein kinase is required for radiation-induced mitotic delay
35. Flow cytometric analysis of X-ray sensitivity in ataxia-telangiectasia
36. Flow cytometric estimation of cell cycle parameters using a monoclonal antibody to bromodeoxyuridine
37. Screening test for ataxia-telangiectasia
38. Cell cycle dependence of mitotic delay in X-irradiated normal and ataxia-telangiectasia fibroblasts
39. Ataxia-telangiectasia (208900; 208910; 208920)
40. Abnormal retention of X-irradiated ataxia-telangiectasia fibroblasts in G2 phase of the cell cycle, cellular RNA content, chromatin stability and the effects of 3-aminobenzamide
41. A rapid single step staining technique for DNA analysis by flow microfluorimetry
42. Ataxia-telangiectasia, a human mutation with abnormal radiation sensitivity
43. DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants. Comparisons to ataxia-telangiectasia cells
44. Mimosine reversibly arrests cell cycle progression at the G1-S phase border
45. Cell death chromosome damage and mitotic delay in normal human, ataxia-telangiectasia and retinoblastoma fibroblasts after X-irradiation