The epigenetics of multiple sclerosis: Clues to etiology and a rationale for immune therapy

Annual Review of Neuroscience

Volumn 17, Issue , 1994, Pages 247-265

  Steinman, Lawrence ^a   Miller, Ariel ^b   Bernard, Claude C A ^c   Oksenberg, Jorge R ^a  

^a STANFORD UNIVERSITY   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

autoimmunity; HLA; multiple sclerosis; T cell receptor

Indexed keywords

MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

AUTOIMMUNITY; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; REVIEW;

EID: 0028213349     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.ne.17.030194.001335     Document Type: Review

References (84)

1. Acha-Orbea, H, Mitchell DJ, Timmermann L, et al. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263-73
2. Allegretta M, Nicklas J, Sriram S, Albertini RJ. 1990. T cells responsive to myelin basic protien in patients with multiple sclerosis. Science 47:718-21
3. Beall SS, Concannon P, Charmley P, et al. 1989. The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis. J. Neuroimmunol. 21:59-66
4. Beall SS, McFarlin D, McFarland H, et al. 1991. Susceptibility for MS is determined by inheritance of a 175 kb region of the TcR-β chain locus in conjunction with HLA class II genes. Am. J. Hum. Genetics 49S:21
5. Begovich AB, McClure GR, Suraj VC, et al. 1992. Polymorphism, recombination and linkage disequilibrium within the HLA class II region. J. Immunol. 148:249-58
6. Bell RB, Steinman L. 1992. Specific immunotherapeutic strategies: Lessons from myelin basic protein induced EAE. In Treatment of MS: Trial Design, Results and Future Perspectives, ed. RA Rudick, DE Goodkin, pp. 282-99. London: Springer Verlag
7. Ben-Nun A, Liblau R, Cohen L, et al. 1991. Restricted TCR Vβ gene usage by myelin basic protein-specific T cell clones in multiple sclerosis: predominant genes vary in individuals. Proc. Natl. Acad. Sci. USA 88:2466-70
8. Bernard CCA, Randell VB, Horvath L, et al. 1981. Antibody to myelin basic protein in extracts of multiple sclerosis brain. Immunology 43:447-57
9. Bitar D, Whitacre CC. 1988. Suppression of EAE by the oral administration of myelin basic protein. Cell. Immunol. 112:364-70
10. Bornstein MB, Miller A, Slagle S, et al. 1987. A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N. Engl. J. Med. 317:408-14
11. Bottazzo GF, Dean BM, McNally JM, et al. 1985. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulin. N. Engl. J. Med. 313:353-57
12. Brocke S, Gaur A, Piercy C, Gautam A, Gijhelsk K, et al. Induction of relapsing paralysis in EAE by bacterial superantigen. Nature In press
13. Broeren CPM, Verjans GM, van Eden W, et al. 1991. Conserved nucleotide sequences at the 5′ end of T cell receptor variable genes facilitate polymerase chain reaction amplification. Eur. J. Immunol. 21:569-75
14. Brosnan C, Selmaj K, Raine CS. 1988. Hypothesis: a role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J. Neuroimmunol. 18:87-94
15. Bugawan TL, Begovich AB, Erlich HA. 1990. Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes. Immunogenetics 32:231-41
16. Bugawan TL, Erlich HA. 1991. Rapid typing of HLA-DQ1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA. Immunogenetics 33:163-70
17. Burns FR, Li X, Shen N, et al. 1989. Both rat and mouse T cell receptors specific for the encephalitogenic determinants of myelin basic protein use similar Vα and Vβ chain genes. J. Exp. Med. 169:27-39
18. Chothia C, Boswell DR, Lesk AM. 1988. The outline structure of the T cell alpha-beta receptor. EMBO J. 7:3745-55
19. Davis M, Bjorkman PJ. 1988. T cell antigen receptor genes and T-cell recognition. Nature 334:395-402
20. Fujinami RS, Oldstone MBA. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity. Science 230:1043-45
21. Gautam AM, Pearson C, Smilek D, et al. 1992. A polyalanine peptide containing only five native myelin basic protein residues induces autoimmune encephalomyelitis. J. Exp. Med. 176:605-9
22. Giegerich G, Pette M, Meinl E, et al. 1992. Diversity of T cell receptor alpha and beta chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes. Eur. J. Immunol. 22:753-58
23. Gold DP, Offner H, Sun D, et al. 1991. Analysis of TCR β chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J. Exp. Med. 174:1467-76
24. Gold DP, Vainiene M, Celnik B, et al. 1992. Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased TCR Vβ expression predominates in spinal cord infiltrating T cells. J. Immunol. 148:1712-17
25. Gulwani-Akolkar B, Posnett DN, Janson CH, et al. 1991. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J. Exp. Med. 174:1139-46
26. Helmuth R, Fildes N, Blake E, et al. 1990. HLA-DQ alpha allele and genotype frequencies in various human populations, determined by using enzymatic amplification and oligonucleotide probes. Am. J. Hum. Genet. 47:515-23
27. Higgins PJ, Weiner HL. 1988. Suppression of EAE by oral administration of myelin basic protein and its fragments. J Immunol. 140:440-5
28. Hillert J, Leng C, Olerup O. 1992. T-cell receptor α chain germline gene polymorphisms in multiple sclerosis. Neurology 42: 80-84
29. Hodgkinson S, Lindsey JW, Allegretta M, et al. 1992. Phase I study of chimeric anti-CD4 monoclonal antibody in MS. Neurology 42:209 (Abstr)
30. Howell MD, Winters ST, Olee T, et al. 1989. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246:668-70
31. Jahnke U, Fischer E, Alvord E. 1985. Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis. Science 229:282-84
32. Johnson RT, Griffin RE, Hirsch RL, et al. 1984. Measles encephalitis - clinical and immunological studies. N. Engl. J. Med. 310:137-41
33. Jorgensen J, Esser U, Fazekas de St. Groth B, et al. 1992. Mapping TCR/peptide contacts by variant peptide immunization of single-chain TCR transgenics. Nature 355:224-30
34. Kappler JW, Roehm N, Marrack P. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273-80
35. Karin N, Szafer F, Mitchell D, et al. 1993. Selective and non-selective stages homing of T lymphocytes to the central nervous system during experimental allergic enephalomyelins. J. Immunol. 150:4116-24
36. Kotzin B, Karaturi S, Chou Y, et al. 1991. Preferential T cell receptor V beta usage in myelin basic protein reactive to T cell clones from patients with multiple sclerosis. Proc. Natl. Acad. Sci. USA 88:9161-65
37. Lee SJ, Wucherpfennig KW, Brod SA, et al. 1991. Common T cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann. Neurol. 29:33-40
38. Lider O, Santos LMB, Lee CSY. 1989. Suppression of experimental allergic encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J. Immunol. 142:748-52
39. Martin R, Howell MD, Jaraquemada D, et al. 1991. A myelin basic protein peptide is recognized in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med. 173:19-24
40. Martino G, Olsson T, Fredrikson S, et al. 1991. Cells producing antibodies specific for myelin basic protein region 70-89 are predominant in cerbrospinal fluid from patients with MS. Eur. J. Immunol. 21:2971-6
41. Mattson DH, Roos RP, Arnason BGW. 1980. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panenecephalitis brains. Nature 287:335-37
42. McFarlin DE, McFarland HF. 1982. Multiple sclerosis. N. Engl. J. Med. 307:1183-88
43. Miller A, Hafler DA, Weiner HL. 1991. Tolerance and suppressor mechanisms in EAE: Implications for immunotherapy of human autoimmune diseases. FASEB J. 5:2560-6
44. Miller A, Lider O, Roberts B, et al. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein supress both in vitro and in vivo immune responses by the release of TGFβ after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89:421-5
45. Miller A, Lider O, Weiner HL. 1991. Antigen-driven bystander suppression following oral administration of antigens. J. Exp. Med. 174:791
46. Morahan G, Allison J, Peterson MG, Malcolm L. 1989. Sequence of the Vβ13 gene used by an influenza-specific T cell. Immunogenetics 30:311-13
47. Oksenberg JR, Panzara MA, Begovich AB, et al. 1993. Selection for T cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for myelin basic protein peptide 87-106 in brain lesions of multiple sclerosis. Nature. 362:68-70
48. Oksenberg JR, Sherritt M, Begovich AB. 1989. T-cell receptor V alpha and C alpha alleles associated with multiple sclerosis and myasthenia gravis. Proc. Natl. Acad. Sci. USA 86:988-92
49. Oksenberg JR, Steinman, L. 1990. The role of the MHC and T cell receptor in susceptibility to multiple sclerosis. Curr. Opinion Immunol. 2:619-21
50. Oksenberg JR, Stuart S, Begovich AB, et al. 1990. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature 345: 344-46
51. Olsson T, Baig S, Hojeberg B, Link H. 1990. Antimyelin basic protein and antimyelin antibody-producing cells in MS. Ann. Neurol. 27:132-6
52. Ota K, Matsui M, Milford E, et al. 1990. T cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346:183-87
53. Paliard X, West S, Lafferty J, et al. 1991. Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325-29
54. Panzara MA, Gussoni E, Steinman L, Oksenberg J. 1992. Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. Biotechniques 12(5): 728-735
55. Pette M, Fujita K, Kitze B, et al. 1990. Myelin basic protein specific T cell lines from MS patients and healthy individuals. Neurology 40:1770-76
56. Powell MB, Mitchell D, Lederman J, et al 1990. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2:539-44
57. Ruddle NH, Bergman CM, McGrath KM. 1990. An antibody to lymphotoxin and TNF prevents transfer of EAE. J. Exp. Med. 172:1193-200
58. Sakai K, Sinha A, Mitchell DJ. 1988a. Involvement of distinct T cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc. Natl. Acad. Sci. USA 85:8608-12
59. Sakai K, Zamvil SS, Mitchell DJ, et al. 1988b. Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein. J. Neuroimmunol. 19:21-32
60. Scharf SJ, Griffith R, Erlich HA. 1991. Rapid typing of DNA sequence polymorphism at the HLA-DRB1 locus using the polymerase chain reaction and nonradioactive oligonucleotide probes. Hum. Immunol. 30:190-201
61. Seboun E, Robinson MA, Doolittle TH, et al. 1989. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell 57:1095-100
62. Selmaj K, Brosnan CF, Raine CS. 1991. Colocalization of TCR γδ lymphocytes and hsp65+ oligodendrocytes in multiple sclerosis. Proc. Natl. Acad. Sci. USA 88:6452-56
63. Sharief MK, Hentges R. 1991. Association between TNFa and disease progression in patients with MS. N. Engl. J. Med. 325:467-72
64. Sherritt MA, Oksenberg J, Kerlero de Rosbo N, Bernard CCA. 1992. Influence of HLA-DR2, HLA-DPw4, T cell receptor α chain genes on the susceptibility to multiple sclerosis. Int. Immunol. 4(2):177-181
65. Steinman L. 1991. The development of rational strategies for selective immunotherapy against demyelinating disease. Adv. Immunol. 49:357-79
66. Steinman L, Rosenbaum JT, Sriram, S, McDevitt HO. 1981. In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc. Natl. Acad. Sci. USA 78: 7111-14
67. Steinman L, Solomon D, Lim M, et al. 1983. Prevention of experimental allergic encephalitis with in vivo administration of anti I-A antibody. Decreased accumulation of radiolabelled lymph node cells in the central nervous system. J. Neuroimmunol. 5:91-97
68. Teitelbaum D, Aharoni R, Arnon R, Sela M. 1988. Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1. Proc. Natl. Acad. Sci. USA 85:9724-8
69. Terasaki PI, Park MS, Opelz G, Ting A. 1976. Multiple sclerosis and high incidence of a B-lymphocyte antigen. Science 193:1245-47
70. Tillinghast JP, Behlke MA, Loh D. 1986. Structure and diversity of the human TCR beta chain variable region genes. Science 233:879-83
71. Traugott U, Reinherz E, Raine CS. 1982. Multiple sclerosis: Distribution of T cell subsets within active chronic lesions. Science 219:308-10
72. Urban JL, Kumar V, Kono DH, et al. 1988. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577-92
73. Vandenbark AA, Chou Y, Bourdette D, et al. 1992. TCR peptides induce autoregulation in MS. Neurology 42:186 (abstract)
74. Vandenbark AA, Hashim G, Offner H. 1989. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541-44
75. Vartdal F, Sollid L, Vandvik B. 1989. Patients with multiple sclerosis carry DQβ1 genes which encode shared polymorphic amino acid sequences. Hum. Immunol. 25:103-10
76. Walsh MJ, Tourtellotte WW. 1986. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA and IgM in multiple sclerosis. J. Exp. Med. 163:41-53
77. Watanabe R, Wege H, ter Meujlen V. 1983. Adoptive transfer of EAE-like lesions from rats with corona virus-induced demyelination and encephalomyelitis. Nature 305:50-3
78. Weiner HL, Mackin GA, Matsui M, et al. 1993. Double blind pilot trial of oral polerization with myelin antigens in multiple sclerosis. Science 259:1321-24
79. Wraith DC, McDevitt HO, Steinman L, Acha-Orbea H. 1989a. T cell recognition as the target for immune intervention in autoimmune disease. Cell 57:709-15
80. Wraith DC, Smilek DE, Mitchell DJ, et al. 1989b. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 59:247-55
81. Wucherpfennig K, Newcombe J, Li H, et al. 1992. Polyclonal TCR Vα-Vβ repertoire in active multiple sclerosis lesions. J. Exp. Med. 175:993-1002
82. Wucherpfennig K, Ota K, Endo N. 1990. Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248:1016-19
83. Yednock TA, Cannon C, Fritz L, et al. 1992. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1integrin. Nature 356:63-66
84. Zamvil SS, Steinman L. 1992. The pathogenesis of demyelinating disease in the central nervous system and the development of selective immunotherapy. Curr. Neurol. 12: 42-69