Impaired (S)-warfarin metabolism catalysed by the R144c allelic variant of CYP2c9

Pharmacogenetics

Volumn 4, Issue 1, 1994, Pages 39-42

  Rettie, Allan E ^a   Wienkers, Larry C ^a   Gonzalez, Frank J ^b   Tragcr, William F ^a   Korzekwa, Kenneth R ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYWARFARIN; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; METHYLHYDROXYTOLBUTAMIDE; TOLBUTAMIDE; UNCLASSIFIED DRUG; WARFARIN;

ALLELE; ARTICLE; CATALYSIS; CELL LINE; CONTROLLED STUDY; DRUG METABOLISM; ENANTIOMER; GENE EXPRESSION; HUMAN; HUMAN CELL; PHARMACOGENETICS; PRIORITY JOURNAL;

ALLELES; CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; RECOMBINANT PROTEINS; STEREOISOMERISM; SUPPORT, U.S. GOV'T, P.H.S.; TOLBUTAMIDE; TUMOR CELLS, CULTURED; WARFARIN;

EID: 0028210729     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199402000-00005     Document Type: Article

References (21)

1. Aoyama T. Korzekwa KR. Nagata K, Gillette J, Gelboin HV, Gonzalez FJ. cDNA-directed expression of rat testosterone 7a-hydroxylase using the modified vaccinia virus, T7-RNA- polymerase system and evidence for 6a-hydroxylation and ∆h-testosterone formation. Eur j Bioche m1989: 181, 331-336
2. Gonzalez FJ, Aoyama T, Gelboin HV. Expression of mammalian cytochrome P450 using vaccinia virus. Meth Enzymol 1991: 206, 85-93
3. Gotoh O. Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J Biol Chem 1992: 267, 83-90
4. Kaminsky LS, de Morais SMF, Faletto MB, Dunbar DA, Goldstein JA. Correlation of human cytochrome P4502C substrate specificities with primary structure: Warfarin as a probe. Mol Pharmacol 1993: 43, 234-239
5. Kimura S, Pastewka J, Gelboin HV, Gonzalez FJ. cDNA and amino acid sequences of two members of the human IIC gene subfamily. Nucleic Acid Res 1987: 15, 10053-10054
6. Kondo M, Zhao J, Leeman T, Dayer P. Biotransformation of oxicam NSAID’s by human cytochrome P450TB (CYP2C). Abstracts of the Vth World Conference on Clinical Pharmacology and Therapeutics. Yokohama, Japan 1992: 243
7. Korzekwa KR, Jones JP. Predicting the cytochrome P450 mediated metabolism of xenobiotics. Pharmacogenetics 1993: 3, 1-18
8. Lowry OH. Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951: 193, 265-272
9. Meehan RR, Gosden JR, Rout D, Hastie ND, Friedberg T. Adesnik M. Buckland R. van Hehyningen V, Fletcher J, Spurr NK, Sweeney J. Wolf CR. Human cytochrome P-450 PB-1: A multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10. Am J Hum Genet 1988: 42, 26-37
10. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, Okuda K, Nebert DW. The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes and nomenclature. DNA Cell Biol 1993: 12, 1-51
11. Omura T, Sato R. Carbon monoxide-binding pigment of liver microsomes. J Biol Chem 1964: 39, 2379-2385
12. Relling MV, Aoyama T, Gonzalez FJ, Meyer, UA. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450’s in the CYP2C family. J Pharmacol Exp Ther 1990: 252, 442-447
13. Rettie AE, Korzekwa KR, Kunze KL, Lawrence RF. Eddy AC, Aoyama T, Gelboin HV, Gonzalez FJ, Trager WF. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin - drug interactions. Chem Res Toxicol 1992: 5, 54-59
14. Romkes M. Faletto MB. Blaidsell JA, Raucy JL, Goldstein JA. Cloning and expression of complementary DNA’s for multiple members of the human cytochrome P45OIIC subfamily. Biochemistry 1991: 30, 3247-3255
15. Srivastava, PK, Yun C-H, Beaune PH, Ged C, Guengerich, FP. Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4’-hydroxylase cytochrome P-450 enzymes. Mol Pharmacol 1991: 40. 69-79
16. Tagg J, Yasuda DM, Tanabe M, Mitoma C. Metabolic studies of tolbutamide in the rat. Biochem Pharmacol 1967: 16, 143-153
17. Veronese ME, Mackenzie PL, Doecke CJ, McManus ME, Miners JO, Birkett. DJ. Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9. Biochem Biophys Res Commun 1991: 175, 1112-1118
18. Veronese MV, Doecke CJ. Mackenzie PI. McManus ME, Miners JO, Rees DLP, Gasser R, Meyer UA, Birkett DJ. Site-directed mutation studies of human liver cytochrome P450 isoenzymes in the CYP2C subfamily. Biochem J 1993: 289, 533-538
19. Wrighton SA, Stevens JC. The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 1992: 22, 1-21
20. Yasumori T, Kawano S, Nagata K, Shimada M. Yamazoe Y, Kato R. Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. J Biochem 1987: 102, 1075-1082
21. Yasumori T, Yamazoe Y, Kato R. Cytochrome P-450 human-2 (P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: Differences in substrate and stereoselectivities among microheterogenous P-450IIC species expressed in yeasts. J Biochem 1991: 109, 711-717